Disease relevance of RPL11

• Ribosomal protein L11 from Escherichia coli specifically binds to a highly conserved region of 23S ribosomal RNA [1].

High impact information on RPL11

• The ribosomal protein L11 binds to and suppresses the E3 ligase function of HDM2, thus activating p53 [2].
• Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation [2].
• Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1-->p35 by in situ hybridization [3].
• In lower protists, mitochondrial RPL11 is encoded by the mitochondrial genome, but higher organisms, including animals, fungi and plants, do not have genes for RPL11 in their mitochondrial genomes, suggesting that transfer of the genetic information for RPL11 from the mitochondrial genome to the nucleus was a very early event in evolution [4].

Associations of RPL11 with chemical compounds

• Additionally, in olomoucine II-treated cells, Mdm2 was found to form a complex with the ribosomal protein L11, which inhibits Mdm2 ubiquitin ligase function [5].

Other interactions of RPL11

• Here we report that the human homologue of MDM2, HDM2, binds to ribosomal protein L11 [6].
• Activation of ribosomal protein L11 and the Mdm2 complex of the p53 pathway may be counterbalanced by the hyperproliferative conditions [7].

References