Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CCL3 - chemokine (C-C motif) ligand 3

Macaca mulatta

Hofmann-Lehmann, R. et al., Chéret, A. et al., Teleshova, N. et al., Pido-Lopez, J. et al.

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Disease relevance of CCL3

A dose-dependent increase of A3G in CCL3- or HSP70-stimulated CD4(+) T cells was associated with inhibition in HIV-1 infectivity [1].
Macrophage inflammatory protein-1 alpha mRNA expression in mononuclear cells from different tissues during acute simian immunodeficiency virus strain mac251 infection of macaques [2].

High impact information on CCL3

This was more pronounced when cells were exposed to additional stimuli in vitro, producing IFN-alpha, IL-3, IL-6, IL-12, TNF-alpha, CCL2, CCL3, CCL5, and CXCL8 [3].
In addition, MIP-1 alpha, MIP-1 beta, and RANTES mRNA expression increased in viremic monkeys with decreased CD4(+) T cell counts; gene expression was inversely correlated with CD4(+) T cell counts, but not viral load [4].

References

Stimulation of Cell Surface CCR5 and CD40 Molecules by Their Ligands or by HSP70 Up-Regulates APOBEC3G Expression in CD4+ T Cells and Dendritic Cells. Pido-Lopez, J., Whittall, T., Wang, Y., Bergmeier, L.A., Babaahmady, K., Singh, M., Lehner, T. J. Immunol. (2007) [Pubmed]
Macrophage inflammatory protein-1 alpha mRNA expression in mononuclear cells from different tissues during acute simian immunodeficiency virus strain mac251 infection of macaques. Chéret, A., Caufour, P., Le Grand, R., Théodoro, F., Boussin, F., Vaslin, B., Dormont, D. AIDS (1997) [Pubmed]
Local and Systemic Effects of Intranodally Injected CpG-C Immunostimulatory-Oligodeoxyribonucleotides in Macaques. Teleshova, N., Kenney, J., Van Nest, G., Marshall, J., Lifson, J.D., Sivin, I., Dufour, J., Bohm, R., Gettie, A., Robbiani, M. J. Immunol. (2006) [Pubmed]
Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection. Hofmann-Lehmann, R., Williams, A.L., Swenerton, R.K., Li, P.L., Rasmussen, R.A., Chenine, A.L., McClure, H.M., Ruprecht, R.M. AIDS Res. Hum. Retroviruses (2002) [Pubmed]

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