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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BICD1  -  bicaudal D homolog 1 (Drosophila)

Homo sapiens

Synonyms: Bic-D 1, Protein bicaudal D homolog 1
 
 
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High impact information on BICD1

  • Conversely, overexpression of the carboxy-terminal domain of BICD, which can interact with Rab6a but not with cytoplasmic dynein, inhibits microtubule minus-end-directed movement of green fluorescent protein (GFP)-Rab6a vesicles and induces an accumulation of Rab6a and COPI-independent ER cargo in peripheral structures [1].
  • These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization [2].
  • Analysis of the predicted amino acid sequence of the BICD1 cDNA clones indicates that the sequence similarity is essentially limited to the amphipatic helices and the leucine zipper, but the conserved order of these domains suggests a similar function of the protein in mammalians [3].
  • The conserved structural characteristics of the BICD1 protein and its expression in muscle and especially brain suggest that BICD1 is a component of a cytoskeleton-based mRNA sorting mechanism conserved during evolution [3].

References

  1. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Matanis, T., Akhmanova, A., Wulf, P., Del Nery, E., Weide, T., Stepanova, T., Galjart, N., Grosveld, F., Goud, B., De Zeeuw, C.I., Barnekow, A., Hoogenraad, C.C. Nat. Cell Biol. (2002) [Pubmed]
  2. GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. Fumoto, K., Hoogenraad, C.C., Kikuchi, A. EMBO J. (2006) [Pubmed]
  3. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Baens, M., Marynen, P. Genomics (1997) [Pubmed]
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