The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Fhl2  -  four and a half LIM domains 2

Rattus norvegicus

Synonyms: Dral, FHL-2, Four and a half LIM domains protein 2, LIM domain protein DRAL, SLIM-3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Fhl2

  • Finally, FHL2 partially antagonized the cardiac hypertrophic response induced by activated MEK-1, GATA4, and phenylephrine agonist stimulation [1].
  • Interestingly, less ADAM-17 was detected at the surface of wild-type mouse macrophages compared to FHL2 deficient macrophages [2].
  • Using the yeast two-hybrid system, we showed that ADAM-17 interacts with the Four and Half LIM domain 2 protein (FHL2), a LIM domain protein that is involved in multiple protein-protein interaction [2].
  • FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity [2].


  1. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Purcell, N.H., Darwis, D., Bueno, O.F., Müller, J.M., Schüle, R., Molkentin, J.D. Mol. Cell. Biol. (2004) [Pubmed]
  2. FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. Canault, M., Tellier, E., Bonardo, B., Mas, E., Aumailley, M., Juhan-Vague, I., Nalbone, G., Peiretti, F. J. Cell. Physiol. (2006) [Pubmed]
WikiGenes - Universities