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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fhl2  -  four and a half LIM domains 2

Rattus norvegicus

Synonyms: Dral, FHL-2, Four and a half LIM domains protein 2, LIM domain protein DRAL, SLIM-3, ...
 
 
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High impact information on Fhl2

  • Finally, FHL2 partially antagonized the cardiac hypertrophic response induced by activated MEK-1, GATA4, and phenylephrine agonist stimulation [1].
  • Interestingly, less ADAM-17 was detected at the surface of wild-type mouse macrophages compared to FHL2 deficient macrophages [2].
  • Using the yeast two-hybrid system, we showed that ADAM-17 interacts with the Four and Half LIM domain 2 protein (FHL2), a LIM domain protein that is involved in multiple protein-protein interaction [2].
  • FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity [2].

References

  1. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Purcell, N.H., Darwis, D., Bueno, O.F., Müller, J.M., Schüle, R., Molkentin, J.D. Mol. Cell. Biol. (2004) [Pubmed]
  2. FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. Canault, M., Tellier, E., Bonardo, B., Mas, E., Aumailley, M., Juhan-Vague, I., Nalbone, G., Peiretti, F. J. Cell. Physiol. (2006) [Pubmed]
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