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Gene Review

HEATR6  -  HEAT repeat containing 6

Homo sapiens

Synonyms: ABC1, Amplified in breast cancer protein 1, FLJ22087, HEAT repeat-containing protein 6
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High impact information on HEATR6

  • Role of ABC1 gene in cholesterol efflux and atheroprotection [1].
  • LXRs have been shown to regulate multiple genes of lipid metabolism, including ABCA1 (formerly known as ABC1) [2].
  • Four unknown ABC1 kinases were identified, possibly involved in regulation of quinone monooxygenases [3].
  • The ABCA1 (ABC1) gene product translocates intracellular cholesterol and phospholipids out of macrophages [4].
  • At least in the phagocyte, this rearrangement may depend on the activity of an ABC ATPase, termed ABC1 in mammals and ced-7 in C. elegans [5].

Analytical, diagnostic and therapeutic context of HEATR6

  • Expression of WT macrophage ABCA1 in ABC1(-/-) mice resulted in a small but significant increase in apoA-I levels starting 2 weeks after transplantation [6].


  1. Role of ABC1 gene in cholesterol efflux and atheroprotection. Owen, J.S. Lancet (1999) [Pubmed]
  2. A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. Sparrow, C.P., Baffic, J., Lam, M.H., Lund, E.G., Adams, A.D., Fu, X., Hayes, N., Jones, A.B., Macnaul, K.L., Ondeyka, J., Singh, S., Wang, J., Zhou, G., Moller, D.E., Wright, S.D., Menke, J.G. J. Biol. Chem. (2002) [Pubmed]
  3. Protein profiling of plastoglobules in chloroplasts and chromoplasts. A surprising site for differential accumulation of metabolic enzymes. Ytterberg, A.J., Peltier, J.B., van Wijk, K.J. Plant Physiol. (2006) [Pubmed]
  4. Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases. Efferth, T. Ageing Res. Rev. (2003) [Pubmed]
  5. Transbilayer phospholipid movement and the clearance of apoptotic cells. Williamson, P., Schlegel, R.A. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels. Haghpassand, M., Bourassa, P.A., Francone, O.L., Aiello, R.J. J. Clin. Invest. (2001) [Pubmed]
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