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TFB2M  -  transcription factor B2, mitochondrial

Homo sapiens

Synonyms: Dimethyladenosine transferase 2, mitochondrial, FLJ22661, FLJ23182, HCV NS5A-transactivated protein 5, Hepatitis C virus NS5A-transactivated protein 5, ...
 
 
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High impact information on TFB2M

  • Here we report that mitochondrial transcription factors B1 (TFB1M) and B2 (TFB2M) are necessary for basal transcription of mammalian mitochondrial DNA (mtDNA) [1].
  • Surprisingly, we found two different transcription factors (TFB1M and TFB2M) that each interact with mitochondrial RNA polymerase in human mitochondria, whereas there is only one such factor in budding yeast mitochondria [2].
 

Biological context of TFB2M

  • These regions display conserved linkage synteny with human Chr 6 and Chr 1, where TFB1M and TFB2M map [2].

References

  1. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.G., Gustafsson, C.M. Nat. Genet. (2002) [Pubmed]
  2. Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. Rantanen, A., Gaspari, M., Falkenberg, M., Gustafsson, C.M., Larsson, N.G. Mamm. Genome (2003) [Pubmed]
 
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