The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TFB2M  -  transcription factor B2, mitochondrial

Homo sapiens

Synonyms: Dimethyladenosine transferase 2, mitochondrial, FLJ22661, FLJ23182, HCV NS5A-transactivated protein 5, Hepatitis C virus NS5A-transactivated protein 5, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TFB2M

  • Here we report that mitochondrial transcription factors B1 (TFB1M) and B2 (TFB2M) are necessary for basal transcription of mammalian mitochondrial DNA (mtDNA) [1].
  • Surprisingly, we found two different transcription factors (TFB1M and TFB2M) that each interact with mitochondrial RNA polymerase in human mitochondria, whereas there is only one such factor in budding yeast mitochondria [2].

Biological context of TFB2M

  • These regions display conserved linkage synteny with human Chr 6 and Chr 1, where TFB1M and TFB2M map [2].


  1. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.G., Gustafsson, C.M. Nat. Genet. (2002) [Pubmed]
  2. Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. Rantanen, A., Gaspari, M., Falkenberg, M., Gustafsson, C.M., Larsson, N.G. Mamm. Genome (2003) [Pubmed]
WikiGenes - Universities