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Gene Review

SEMA4A  -  sema domain, immunoglobulin domain (Ig),...

Homo sapiens

Synonyms: CORD10, FLJ12287, RP35, SEMAB, SEMB, ...
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Disease relevance of SEMA4A

  • To investigate its association with human retinal degeneration, mutation screening of the SEMA4A gene was carried out on 190 unrelated patients suffering from a variety of eye diseases [1].

High impact information on SEMA4A

  • A short course of treatment using rifampin, isoniazid and ethambutol was then devised, the method depending on the severity of the disease using the Semb classification [2].
  • A pioneer in Norwegian gastroenterology has died (Lars S Semb) [3].


  1. Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases. Abid, A., Ismail, M., Mehdi, S.Q., Khaliq, S. J. Med. Genet. (2006) [Pubmed]
  2. Genitourinary tuberculosis: a study of short course regimens. Gow, J.G. J. Urol. (1976) [Pubmed]
  3. A pioneer in Norwegian gastroenterology has died (Lars S Semb). Myren, J., Gjone, E. Scand. J. Gastroenterol. (1980) [Pubmed]
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