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Gene Review:

Mthfd1 - methylenetetrahydrofolate dehydrogenase...

Rattus norvegicus

Synonyms: C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase, Mthfd

Cheek, W.D. et al., Appling, D.R. et al.

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High impact information on Mthfd1

C1-THF synthase immunoreactivity was detected in both distal and proximal epithelial cells [1].
C1-tetrahydrofolate synthase (C1-THF synthase), a eukaryotic trifunctional enzyme, catalyzes three sequential folate-mediated one-carbon interconversions [2].

Analytical, diagnostic and therapeutic context of Mthfd1

These results emphasize the advantages of an immunoassay in studying the regulation of C1-THF synthase [2].
Western blot analysis indicated that the antisera is specific for one protein in crude liver extracts which comigrates with purified C1-THF synthase [2].

References

Immunolocalization of C1-tetrahydrofolate synthase in the rat kidney. Appling, D.R., Ayo, S.H., Kreisberg, J.I. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
Purification, immunoassay, and tissue distribution of rat C1-tetrahydrofolate synthase. Cheek, W.D., Appling, D.R. Arch. Biochem. Biophys. (1989) [Pubmed]

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