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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POLR1E  -  polymerase (RNA) I polypeptide E, 53kDa

Homo sapiens

Synonyms: DNA-directed RNA polymerase I subunit E, DNA-directed RNA polymerase I subunit RPA49, FLJ13390, FLJ13970, PAF53, ...
 
 
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High impact information on POLR1E

  • These results, together with the accumulation of PAF53 in the nucleolus of growing cells, suggest that PAF53 is involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBF for the active rRNA synthesis [1].
  • We previously demonstrated the critical role of RNA polymerase I (Pol I)-associated factor PAF53 in mammalian rRNA transcription [2].
  • The results presented support a model wherein regulation of the binding of UBF to Rb and, perhaps the cellular content of PAF53, are components of the mechanism through which cell cycle and rDNA transcription are linked [3].
  • In addition, we show by high resolution immunofluorescence analysis that, under conditions of repressed rDNA transcription, including serum starvation, actinomycin treatment und during mitosis, PAF53 remains attached to the transcriptional machinery [4].

References

  1. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. Hanada, K., Song, C.Z., Yamamoto, K., Yano, K., Maeda, Y., Yamaguchi, K., Muramatsu, M. EMBO J. (1996) [Pubmed]
  2. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto, K., Yamamoto, M., Hanada, K., Nogi, Y., Matsuyama, T., Muramatsu, M. Mol. Cell. Biol. (2004) [Pubmed]
  3. RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest. Hannan, K.M., Kennedy, B.K., Cavanaugh, A.H., Hannan, R.D., Hirschler-Laszkiewicz, I., Jefferson, L.S., Rothblum, L.I. Oncogene (2000) [Pubmed]
  4. Constitutive and strong association of PAF53 with RNA polymerase I. Seither, P., Zatsepina, O., Hoffmann, M., Grummt, I. Chromosoma (1997) [Pubmed]
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