Gene Review:
UBTF - upstream binding transcription factor, RNA...
Homo sapiens
Synonyms:
Autoantigen NOR-90, NOR-90, Nucleolar transcription factor 1, UBF, UBF-1, ...
- Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. Voit, R., Kuhn, A., Sander, E.E., Grummt, I. Nucleic Acids Res. (1995)
- Regulation of ribosomal DNA transcription during neonatal cardiomyocyte hypertrophy. Hannan, R.D., Rothblum, L.I. Cardiovasc. Res. (1995)
- Increased expression of UBF is a critical determinant for rRNA synthesis and hypertrophic growth of cardiac myocytes. Brandenburger, Y., Jenkins, A., Autelitano, D.J., Hannan, R.D. FASEB J. (2001)
- Detection of autoantibodies to nucleolar transcription factor NOR 90/hUBF in sera of patients with rheumatic diseases, by recombinant autoantigen-based assays. Fujii, T., Mimori, T., Akizuki, M. Arthritis Rheum. (1996)
- Molecular mechanisms governing species-specific transcription of ribosomal RNA. Bell, S.P., Pikaard, C.S., Reeder, R.H., Tjian, R. Cell (1989)
- Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element. Learned, R.M., Learned, T.K., Haltiner, M.M., Tjian, R.T. Cell (1986)
- Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Jantzen, H.M., Admon, A., Bell, S.P., Tjian, R. Nature (1990)
- Cell cycle-dependent regulation of RNA polymerase I transcription: the nucleolar transcription factor UBF is inactive in mitosis and early G1. Klein, J., Grummt, I. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Upstream binding factor association induces large-scale chromatin decondensation. Chen, D., Belmont, A.S., Huang, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. Pluta, A.F., Earnshaw, W.C. J. Biol. Chem. (1996)
- MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation. Poortinga, G., Hannan, K.M., Snelling, H., Walkley, C.R., Jenkins, A., Sharkey, K., Wall, M., Brandenburger, Y., Palatsides, M., Pearson, R.B., McArthur, G.A., Hannan, R.D. EMBO J. (2004)
- Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF. Kalousek, I., Krízková, P. Cell. Mol. Biol. (Noisy-le-grand) (2000)
- Localization of the human RNA polymerase I transcription factor gene (UBTF) to the D17S183 locus on chromosome 17q21 and construction of a long-range restriction map of the region. Jones, K.A., Black, D.M., Griffiths, B.L., Solomon, E. Genomics (1995)
- The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation. Voit, R., Schnapp, A., Kuhn, A., Rosenbauer, H., Hirschmann, P., Stunnenberg, H.G., Grummt, I. EMBO J. (1992)
- Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Voit, R., Grummt, I. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Cisplatin inhibits synthesis of ribosomal RNA in vivo. Jordan, P., Carmo-Fonseca, M. Nucleic Acids Res. (1998)
- Involvement of in situ conformation of ribosomal genes and selective distribution of upstream binding factor in rRNA transcription. Junéra, H.R., Masson, C., Géraud, G., Suja, J., Hernandez-Verdun, D. Mol. Biol. Cell (1997)
- The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein. Kwon, H., Green, M.R. J. Biol. Chem. (1994)
- RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. Panov, K.I., Panova, T.B., Gadal, O., Nishiyama, K., Saito, T., Russell, J., Zomerdijk, J.C. Mol. Cell. Biol. (2006)
- Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Bell, S.P., Learned, R.M., Jantzen, H.M., Tjian, R. Science (1988)
- UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery. Mais, C., Wright, J.E., Prieto, J.L., Raggett, S.L., McStay, B. Genes Dev. (2005)
- A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway. Grueneberg, D.A., Pablo, L., Hu, K.Q., August, P., Weng, Z., Papkoff, J. Mol. Cell. Biol. (2003)
- The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Lin, C.Y., Tuan, J., Scalia, P., Bui, T., Comai, L. Curr. Biol. (2002)
- Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells. Huang, R., Wu, T., Xu, L., Liu, A., Ji, Y., Hu, G. FASEB J. (2002)
- Molecular analysis of the 5' region of human ribosomal transcription factor UBF. Dühr, S., Torres-Montaner, A., Astola, A., García-Cozar, F.J., Pendón, C., Bolívar, J., Valdivia, M.M. DNA Seq. (2001)
- TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. Friedrich, J.K., Panov, K.I., Cabart, P., Russell, J., Zomerdijk, J.C. J. Biol. Chem. (2005)
- Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. Chan, E.K., Imai, H., Hamel, J.C., Tan, E.M. J. Exp. Med. (1991)
- Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. Matera, A.G., Wu, W., Imai, H., O'Keefe, C.L., Chan, E.K. Genomics (1997)
- A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription. Panov, K.I., Friedrich, J.K., Zomerdijk, J.C. Mol. Cell. Biol. (2001)