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Gene Review

Nphs1  -  nephrosis 1, congenital, Finnish type...

Rattus norvegicus

Synonyms: Nephrin, Nphn, Renal glomerulus-specific cell adhesion receptor
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Disease relevance of Nphs1

  • More hypertrophied glomeruli with lesser nephrin expression may be responsible for albuminuria in the early stage of DN [1].

High impact information on Nphs1


  1. Differential expression of nephrin according to glomerular size in early diabetic kidney disease. Kim, J.J., Li, J.J., Jung, D.S., Kwak, S.J., Ryu, D.R., Yoo, T.H., Han, S.H., Choi, H.Y., Kim, H.J., Han, D.S., Kang, S.W. J. Am. Soc. Nephrol. (2007) [Pubmed]
  2. Assignment of the genes encoding nephrin (Nphs1) and alpha-actinin 4 (Actn4) to rat chromosome 1q22 by in situ hybridization and radiation hybrid mapping. Schulz, A., Marquardt, H., Szpirer, J., Szpirer, C., Kreutz, R. Cytogenet. Cell Genet. (2000) [Pubmed]
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