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Disease relevance of Albuminuria


Psychiatry related information on Albuminuria


High impact information on Albuminuria

  • The primary outcome was the time to the onset of diabetic nephropathy, defined by persistent albuminuria in overnight specimens, with a urinary albumin excretion rate that was greater than 200 microg per minute and at least 30 percent higher than the base-line level [8].
  • Microalbuminuria or overt albuminuria was considered to be present if the ratio of albumin (in micrograms) to creatinine (in milligrams) was 17 to 299 or > or = 300, respectively, for men and 25 to 299 or > or = 300, respectively, for women [9].
  • In the 9 patients older than 10 who had retinopathy or overt albuminuria, the mean plasma prorenin activity was 13.09 +/- 1.43 ng of angiotensin I per liter.second (P less than 0.0001) [10].
  • We examined the role of leukocytic neutral proteinases by comparing the glomerular damage and albuminuria after injection of rabbit anti-mouse GBM antibodies in normal control mice (C57BL/6J, +/+) and in beige mice (C57BL/6J,bg/bg) in which PMN are deficient of the neutral proteinases elastase and cathepsin G [11].
  • In addition, administration of scavengers of reactive oxygen metabolites, such as catalase and desferrioxamine, did not prevent the albuminuria in this model [11].

Chemical compound and disease context of Albuminuria

  • Only 1 of the 20 patients who had consistently normal plasma prorenin values had overt albuminuria (ratio of urinary albumin to creatinine, greater than 0.017) or retinopathy, whereas one or both of these complications appeared in 8 of the 14 who had at least one high prorenin value [10].
  • When the increased albuminuria resulting from dietary protein augmentation is blunted with enalapril, serum albumin concentration is shown to increase in nephrotic rats [12].
  • At day 14 and thereafter, doxorubicin-treated male rats showed albuminuria greater than or equal to 10 g/liter [13].
  • Albuminuria, serum albumin, and serum creatine levels were assessed weekly [13].
  • Here, we confirm this inference by demonstrating that Akita diabetic mice lacking the bradykinin B2 receptor develop overt albuminuria, excreting the equivalent of >550 mg/day albumin in humans, which contrasts with the microalbuminuria (equivalent to <150 mg/day) seen in their simply diabetic littermates [14].

Biological context of Albuminuria


Anatomical context of Albuminuria


Gene context of Albuminuria


Analytical, diagnostic and therapeutic context of Albuminuria


  1. Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. Lelongt, B., Bengatta, S., Delauche, M., Lund, L.R., Werb, Z., Ronco, P.M. J. Exp. Med. (2001) [Pubmed]
  2. Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model. Ichinose, K., Maeshima, Y., Yamamoto, Y., Kitayama, H., Takazawa, Y., Hirokoshi, K., Sugiyama, H., Yamasaki, Y., Eguchi, K., Makino, H. Diabetes (2005) [Pubmed]
  3. Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat. Soulis-Liparota, T., Cooper, M., Papazoglou, D., Clarke, B., Jerums, G. Diabetes (1991) [Pubmed]
  4. Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Kelly, D.J., Zhang, Y., Hepper, C., Gow, R.M., Jaworski, K., Kemp, B.E., Wilkinson-Berka, J.L., Gilbert, R.E. Diabetes (2003) [Pubmed]
  5. Effects of the angiotensin II antagonist valsartan on blood pressure, proteinuria, and renal hemodynamics in patients with chronic renal failure and hypertension. Plum, J., Bünten, B., Németh, R., Grabensee, B. J. Am. Soc. Nephrol. (1998) [Pubmed]
  6. Reduction in glomerular heparan sulfate correlates with complement deposition and albuminuria in active Heymann nephritis. Raats, C.J., Luca, M.E., Bakker, M.A., Van Der Wal, A., Heeringa, P., Van Goor, H., Van Den Born, J., De Heer, E., Berden, J.H. J. Am. Soc. Nephrol. (1999) [Pubmed]
  7. Effective postponement of diabetic nephropathy with enalapril in normotensive type 2 diabetic patients with microalbuminuria. Ahmad, J., Siddiqui, M.A., Ahmad, H. Diabetes Care (1997) [Pubmed]
  8. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. Parving, H.H., Lehnert, H., Bröchner-Mortensen, J., Gomis, R., Andersen, S., Arner, P. N. Engl. J. Med. (2001) [Pubmed]
  9. Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus. Krolewski, A.S., Laffel, L.M., Krolewski, M., Quinn, M., Warram, J.H. N. Engl. J. Med. (1995) [Pubmed]
  10. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. Wilson, D.M., Luetscher, J.A. N. Engl. J. Med. (1990) [Pubmed]
  11. Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase. Schrijver, G., Schalkwijk, J., Robben, J.C., Assmann, K.J., Koene, R.A. J. Exp. Med. (1989) [Pubmed]
  12. A low-protein diet restricts albumin synthesis in nephrotic rats. Kaysen, G.A., Jones, H., Martin, V., Hutchison, F.N. J. Clin. Invest. (1989) [Pubmed]
  13. Time-course study on doxorubicin-induced nephropathy and cardiomyopathy in male and female LOU/M/Wsl rats: lack of evidence for a causal relationship. van Hoesel, Q.G., Steerenberg, P.A., Dormans, J.A., de Jong, W.H., de Wildt, D.J., Vos, J.G. J. Natl. Cancer Inst. (1986) [Pubmed]
  14. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Kakoki, M., Takahashi, N., Jennette, J.C., Smithies, O. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Use of enalapril to attenuate decline in renal function in normotensive, normoalbuminuric patients with type 2 diabetes mellitus. A randomized, controlled trial. Ravid, M., Brosh, D., Levi, Z., Bar-Dayan, Y., Ravid, D., Rachmani, R. Ann. Intern. Med. (1998) [Pubmed]
  16. Glomerular hyperfiltration in the prediction of nephropathy in IDDM: a 10-year follow-up study. Yip, J.W., Jones, S.L., Wiseman, M.J., Hill, C., Viberti, G. Diabetes (1996) [Pubmed]
  17. Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Bonnet, F., Cooper, M.E., Kawachi, H., Allen, T.J., Boner, G., Cao, Z. Diabetologia (2001) [Pubmed]
  18. Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria. Ebbehøj, E., Poulsen, P.L., Hansen, K.W., Knudsen, S.T., Mølgaard, H., Mogensen, C.E. Diabetologia (2002) [Pubmed]
  19. Effect of protein kinase C modulators on the leucocyte Na+/H+ antiport in type 1 (insulin-dependent) diabetic subjects with albuminuria. Ng, L.L., Simmons, D., Frighi, V., Garrido, M.C., Bomford, J. Diabetologia (1990) [Pubmed]
  20. Hydroxyl radicals depolymerize glomerular heparan sulfate in vitro and in experimental nephrotic syndrome. Raats, C.J., Bakker, M.A., van den Born, J., Berden, J.H. J. Biol. Chem. (1997) [Pubmed]
  21. The effect of orlistat-induced weight loss, without concomitant hypocaloric diet, on cardiovascular risk factors and insulin sensitivity in young obese Chinese subjects with or without type 2 diabetes. Tong, P.C., Lee, Z.S., Sea, M.M., Chow, C.C., Ko, G.T., Chan, W.B., So, W.Y., Ma, R.C., Ozaki, R., Woo, J., Cockram, C.S., Chan, J.C. Arch. Intern. Med. (2002) [Pubmed]
  22. Effects of smoking on renal hemodynamics in healthy volunteers and in patients with glomerular disease. Ritz, E., Benck, U., Franek, E., Keller, C., Seyfarth, M., Clorius, J. J. Am. Soc. Nephrol. (1998) [Pubmed]
  23. Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis. Wilson, H.M., Stewart, K.N., Brown, P.A., Anegon, I., Chettibi, S., Rees, A.J., Kluth, D.C. Mol. Ther. (2002) [Pubmed]
  24. Induction of albuminuria in mice: synergistic effect of two monoclonal antibodies directed to different domains of aminopeptidase A. Mentzel, S., van Son, J.P., Dijkman, H.B., Wetzels, J.F., Assmann, K.J. Kidney Int. (1999) [Pubmed]
  25. The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy. Awazu, M., Omori, S., Ishikura, K., Hida, M., Fujita, H. J. Am. Soc. Nephrol. (2003) [Pubmed]
  26. Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy. Adhikary, L., Chow, F., Nikolic-Paterson, D.J., Stambe, C., Dowling, J., Atkins, R.C., Tesch, G.H. Diabetologia (2004) [Pubmed]
  27. Growth hormone receptor antagonism prevents early renal changes in nonobese diabetic mice. Segev, Y., Landau, D., Rasch, R., Flyvbjerg, A., Phillip, M. J. Am. Soc. Nephrol. (1999) [Pubmed]
  28. Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension. Mervaala, E.M., Müller, D.N., Park, J.K., Schmidt, F., Löhn, M., Breu, V., Dragun, D., Ganten, D., Haller, H., Luft, F.C. Hypertension (1999) [Pubmed]
  29. Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Banba, N., Nakamura, T., Matsumura, M., Kuroda, H., Hattori, Y., Kasai, K. Kidney Int. (2000) [Pubmed]
  30. Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure. Kasiske, B.L., O'Donnell, M.P., Garvis, W.J., Keane, W.F. Circ. Res. (1988) [Pubmed]
  31. Detection of potentially reversible diabetic albuminuria. A three-drop agglutination test for urinary albumin at low concentration. Viberti, G.C., Vergani, D. Diabetes (1982) [Pubmed]
  32. Relationship between fasting plasma glucose, atherosclerosis risk factors and carotid intima media thickness in non-diabetic individuals. Temelkova-Kurktschiev, T., Koehler, C., Schaper, F., Henkel, E., Hahnefeld, A., Fuecker, K., Siegert, G., Hanefeld, M. Diabetologia (1998) [Pubmed]
  33. Reduced glomerular filtration rate in asymptomatic diabetic patients: predictor of increased risk for cardiac events independent of albuminuria. Knobler, H., Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., Livschitz, S. J. Am. Coll. Cardiol. (2004) [Pubmed]
  34. Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade: a short-term, randomized, controlled trial. Navarro, J.F., Mora, C., Muros, M., García, J. J. Am. Soc. Nephrol. (2005) [Pubmed]
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