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Gene Review:

CTAGE1 - cutaneous T-cell lymphoma-associated...

Homo sapiens

Synonyms: CT21.1, CT21.2, CTAGE, CTAGE-1, CTAGE-2, ...

Usener, D. et al., Eichmuller, S. et al.

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Disease relevance of CTAGE1

The immunogenic epitope of cTAGE-1 was determined by using epitope mapping and sera of two cutaneous T cell lymphoma patients [1].
Sero-reactivity against cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B was found only in tumor patients (cutaneous T cell lymphoma and melanoma) [1].
Moreover, cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B could be detected in most types of tumor tissues and cell lines at variable frequencies, including those of cutaneous T cell lymphoma, melanoma, head and neck squamous cell carcinoma, breast carcinoma, and colon carcinoma [1].

High impact information on CTAGE1

The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL [2].

References

cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. Usener, D., Schadendorf, D., Koch, J., Dübel, S., Eichmüller, S. J. Invest. Dermatol. (2003) [Pubmed]
Serological detection of cutaneous T-cell lymphoma-associated antigens. Eichmuller, S., Usener, D., Dummer, R., Stein, A., Thiel, D., Schadendorf, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]

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