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Gene Review:

CTAGE5 - CTAGE family, member 5

Homo sapiens

Synonyms: MEA11, MEA6, MGEA, MGEA11, MGEA6, ...

Usener, D. et al., Comtesse, N. et al., Heckel, D. et al., Comtesse, N. et al., Guinn, B.A. et al.

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Disease relevance of CTAGE5

The longest open reading frame was found to be 2412 bp encoding an immunoreactive antigen termed meningioma expressed antigen 6 (MEA6) [1].
The immune response to MGEA6/11 is frequent in both meningioma and glioma patients and may likely be attributed to overexpression of the MGEA6/11 protein in the tumor cells [2].
We conclude that cTAGE-1 and cTAGE-5 are new cancer germline antigens and that tumor-specific splicing of cTAGE genes may lead to further candidate proteins for specific immunotherapy of cutaneous T cell lymphoma and other malignancies [3].
Sero-reactivity against cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B was found only in tumor patients (cutaneous T cell lymphoma and melanoma) [3].
Moreover, cTAGE-1, cTAGE-4, cTAGE-5A, and cTAGE-5B could be detected in most types of tumor tissues and cell lines at variable frequencies, including those of cutaneous T cell lymphoma, melanoma, head and neck squamous cell carcinoma, breast carcinoma, and colon carcinoma [3].

High impact information on CTAGE5

Here we carry out database analysis to investigate the complexity of the MGEA6-related sequences and demonstrate the existence of a multigene family [4].
The MGEA6 multigene family has an active locus on 14q and at least nine pseudogenes on different chromosomes [4].
Somatic hybrid panel mapping and fluorescence in situ hybridization revealed MGEA6-related sequences on different human chromosomes [4].
The tumour antigens RAGE-1 and MGEA6 are expressed more frequently in the less lineage restricted subgroups of presentation acute myeloid leukaemia [5].

Biological context of CTAGE5

We performed phylogenetic analysis and concluded that the MGEA6 pseudogenes may result from more than one retrotransposition event; we calculated divergence times of the pseudogenes to be between 21.5 and 28.9 million years ago [4].

Analytical, diagnostic and therapeutic context of CTAGE5

Sequence analysis predicted membranic localization of MGEA6/11, that was confirmed by cell fractionation [2].
Tumor-specific protein expression of cTAGE-5 was confirmed by Western blotting [3].

References

cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. Heckel, D., Brass, N., Fischer, U., Blin, N., Steudel, I., Türeci, O., Fackler, O., Zang, K.D., Meese, E. Hum. Mol. Genet. (1997) [Pubmed]
MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies. Comtesse, N., Niedermayer, I., Glass, B., Heckel, D., Maldener, E., Nastainczyk, W., Feiden, W., Meese, E. Oncogene (2002) [Pubmed]
cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. Usener, D., Schadendorf, D., Koch, J., Dübel, S., Eichmüller, S. J. Invest. Dermatol. (2003) [Pubmed]
The MGEA6 multigene family has an active locus on 14q and at least nine pseudogenes on different chromosomes. Comtesse, N., Reus, K., Meese, E. Genomics (2001) [Pubmed]
The tumour antigens RAGE-1 and MGEA6 are expressed more frequently in the less lineage restricted subgroups of presentation acute myeloid leukaemia. Guinn, B.A., Gilkes, A.F., Mufti, G.J., Burnett, A.K., Mills, K.I. Br. J. Haematol. (2006) [Pubmed]

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CTAGE5	Bos taurus
CTAGE5	Canis lupus familiaris
ctage5	Danio rerio
MIA2	Gallus gallus
CTAGE5	Macaca mulatta
Ctage5	Mus musculus
CTAGE5	Pan troglodytes
LOC100912115	Rattus norvegicus
ctage5	Xenopus (Silurana) tropicalis

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