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Gene Review

SYCP1  -  synaptonemal complex protein 1

Homo sapiens

Synonyms: CT8, Cancer/testis antigen 8, HOM-TES-14, SCP-1, SCP1, ...
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Disease relevance of SYCP1


High impact information on SYCP1


Chemical compound and disease context of SYCP1

  • The humoral immune response against SCP-1 was associated with the size of tumor, but not with other clinico-pathological parameters such as histology, stage, presence of lymph node metastases, grading, age, gender or gemcitabine treatment [7].

Biological context of SYCP1


Anatomical context of SYCP1


Associations of SYCP1 with chemical compounds


Physical interactions of SYCP1

  • SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments [20].

Other interactions of SYCP1

  • We found that SYCP3, but not SYCP1, aggregates appear in the preleptotene nucleus and some persist up to pachytene [11].
  • Spermatogenic defects were examined in azoospermic men using immunofluorescent SC and MLH1 analysis [10].
  • The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL [21].
  • Immunolocalization analysis shows that MSH4 is present at sites along the synaptonemal complex as soon as homologous chromosomes synapse [22].
  • To shed light on the epigenetic phenotypes among histological subtypes of TGCTs, we investigated the methylation and expression of several cancer testis antigen (CTA) genes (MAGEA1, MAGEA3, and SYCP1) in TGCTs [23].

Analytical, diagnostic and therapeutic context of SYCP1


  1. Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. Türeci, O., Sahin, U., Zwick, C., Koslowski, M., Seitz, G., Pfreundschuh, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells. Neumann, F., Wagner, C., Preuss, K.D., Kubuschok, B., Schormann, C., Stevanovic, S., Pfreundschuh, M. Blood (2005) [Pubmed]
  3. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. Costa, Y., Speed, R., Ollinger, R., Alsheimer, M., Semple, C.A., Gautier, P., Maratou, K., Novak, I., Höög, C., Benavente, R., Cooke, H.J. J. Cell. Sci. (2005) [Pubmed]
  4. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Baker, S.M., Bronner, C.E., Zhang, L., Plug, A.W., Robatzek, M., Warren, G., Elliott, E.A., Yu, J., Ashley, T., Arnheim, N., Flavell, R.A., Liskay, R.M. Cell (1995) [Pubmed]
  5. The genetics and molecular biology of the synaptonemal complex. Page, S.L., Hawley, R.S. Annu. Rev. Cell Dev. Biol. (2004) [Pubmed]
  6. Closely related sequences on human X and Y chromosomes outside the pairing region. Cooke, H.J., Brown, W.A., Rappold, G.A. Nature (1984) [Pubmed]
  7. Serological immune response to cancer testis antigens in patients with pancreatic cancer. Wadle, A., Kubuschok, B., Imig, J., Wuellner, B., Wittig, C., Zwick, C., Mischo, A., Waetzig, K., Romeike, B.F., Lindemann, W., Schilling, M., Pfreundschuh, M., Renner, C. Int. J. Cancer (2006) [Pubmed]
  8. An azoospermic man with a double-strand DNA break-processing deficiency in the spermatocyte nuclei: Case report. Sciurano, R.B., Rahn, M.I., Pigozzi, M.I., Olmedo, S.B., Solari, A.J. Hum. Reprod. (2006) [Pubmed]
  9. Characterization of all human male synaptonemal complexes by subtelomere multiplex-FISH. Codina-Pascual, M., Kraus, J., Speicher, M.R., Oliver-Bonet, M., Murcia, V., Sarquella, J., Egozcue, J., Navarro, J., Benet, J. Cytogenet. Genome Res. (2004) [Pubmed]
  10. Immunofluorescent synaptonemal complex analysis in azoospermic men. Sun, F., Greene, C., Turek, P.J., Ko, E., Rademaker, A., Martin, R.H. Cytogenet. Genome Res. (2005) [Pubmed]
  11. Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes. Roig, I., Liebe, B., Egozcue, J., Cabero, L., Garcia, M., Scherthan, H. Chromosoma (2004) [Pubmed]
  12. Dysfunction of the mitotic:meiotic switch as a potential cause of neoplastic conversion of primordial germ cells. Adamah, D.J., Gokhale, P.J., Eastwood, D.J., Rajpert De-Meyts, E., Goepel, J., Walsh, J.R., Moore, H.D., Andrews, P.W. Int. J. Androl. (2006) [Pubmed]
  13. Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis. Kondoh, N., Nishina, Y., Tsuchida, J., Koga, M., Tanaka, H., Uchida, K., Inazawa, J., Taketo, M., Nozaki, M., Nojima, H., Matsumiya, K., Namiki, M., Okuyama, A., Nishimune, Y. Cytogenet. Cell Genet. (1997) [Pubmed]
  14. Inter-sex variation in synaptonemal complex lengths largely determine the different recombination rates in male and female germ cells. Tease, C., Hultén, M.A. Cytogenet. Genome Res. (2004) [Pubmed]
  15. Determinants for Dephosphorylation of the RNA Polymerase II C-Terminal Domain by Scp1. Zhang, Y., Kim, Y., Genoud, N., Gao, J., Kelly, J.W., Pfaff, S.L., Gill, G.N., Dixon, J.E., Noel, J.P. Mol. Cell (2006) [Pubmed]
  16. The cellular program for the formation and dissolution of the synaptonemal complex in Coprinus. Lu, B.C. J. Cell. Sci. (1984) [Pubmed]
  17. Synaptosomal complexes and associated structures in microspread human spermatocytes. Solari, A.J. Chromosoma (1980) [Pubmed]
  18. Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain. Cui, J.G., Zhang, X., Zhao, Y.H., Chen, C., Bazan, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  19. Cyclophosphamide-induced synaptonemal complex damage during meiotic prophase of female Rattus norvegicus. Cusidó, L., Pujol, R., Egozcue, J., Garćia, M. Mutat. Res. (1995) [Pubmed]
  20. Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. Hamer, G., Gell, K., Kouznetsova, A., Novak, I., Benavente, R., Höög, C. J. Cell. Sci. (2006) [Pubmed]
  21. Serological detection of cutaneous T-cell lymphoma-associated antigens. Eichmuller, S., Usener, D., Dummer, R., Stein, A., Thiel, D., Schadendorf, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  22. MSH4 acts in conjunction with MLH1 during mammalian meiosis. Santucci-Darmanin, S., Walpita, D., Lespinasse, F., Desnuelle, C., Ashley, T., Paquis-Flucklinger, V. FASEB J. (2000) [Pubmed]
  23. Distinctive epigenetic phenotype of cancer testis antigen genes among seminomatous and nonseminomatous testicular germ-cell tumors. Zhang, C., Kawakami, T., Okada, Y., Okamoto, K. Genes Chromosomes Cancer (2005) [Pubmed]
  24. Analysis of non-crossover bivalents in pachytene cells from 10 normal men. Sun, F., Oliver-Bonet, M., Liehr, T., Starke, H., Turek, P., Ko, E., Rademaker, A., Martin, R.H. Hum. Reprod. (2006) [Pubmed]
  25. Karyotyping of human synaptonemal complexes by cenM-FISH. Oliver-Bonet, M., Liehr, T., Nietzel, A., Heller, A., Starke, H., Claussen, U., Codina-Pascual, M., Pujol, A., Abad, C., Egozcue, J., Navarro, J., Benet, J. Eur. J. Hum. Genet. (2003) [Pubmed]
  26. The central region of the synaptonemal complex revealed in three dimensions. Schmekel, K., Daneholt, B. Trends Cell Biol. (1995) [Pubmed]
  27. Nucleoprotein-based nanoscale assembly. Smith, S.S., Niu, L., Baker, D.J., Wendel, J.A., Kane, S.E., Joy, D.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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