High impact information on ISG20L1

• Subcellular distribution of AEN exhibited nuclear colocalization with apoptotic nucleases such as CAD and AIF following irradiation [1].
• Irradiation of AEN-expressing cells resulted in synergistic increase of apoptosis whereas AEN deletion mutant in exonuclease domain did not [1].
• Several of the peptides derived from the sequence W219-V227 of GPIb(alpha) inhibited platelet aggregation, which was primarily dependent on the presence of the amino acid sequence A224-N226 (AEN) [2].
• At the onset of both AEN and AEH, O2 extraction (a-v O2) across the arm increased transiently above that at steady state, the increase being more pronounced during AEN than during AEH (P < 0.05) [3].
• The arteriovenous difference for both lactate and ammonia was similar during AEN and AEH [3].

Biological context of ISG20L1

• Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis [1].

Associations of ISG20L1 with chemical compounds

• The reversal of muscle O2 desaturation was slower in all subjects during AEH (t1/2 = 2.4 +/- 0.2 min) than during AEN (t1/2 = 1.2 +/- 0.2 min; P < 0.01) [3].
• After 10 min of exercise, arterial blood lactate was higher (P < 0.05) during AEH (5.5 +/- 0.2 mmol l-1) than during AEN (4.9 +/- 0.6 mmol l-1), whereas arterial plasma ammonia (NH3) was similar [3].

Other interactions of ISG20L1

• Sequence analysis of AEN revealed exonuclease domain highly similar to that of exonuclease III [1].

References