The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

AIFM1  -  apoptosis-inducing factor, mitochondrion...

Homo sapiens

Synonyms: AIF, Apoptosis-inducing factor 1, mitochondrial, CMT2D, CMTX4, COWCK, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIFM1


Psychiatry related information on AIFM1


High impact information on AIFM1

  • The nuclear localization of AIF can be inhibited by blocking upstream signals of apoptosis [8].
  • The contribution of AIF to cell death depends on the cell type and apoptotic insult and is only seen when caspases are inhibited or not activated [8].
  • Apoptosis-inducing factor (AIF) is a NADH oxidase with a local redox function that is essential for optimal oxidative phosphorylation and for an efficient anti-oxidant defense [8].
  • The absence of AIF can cause neurodegeneration, skeleton muscle atrophy and dilated cardiomyopathy [8].
  • When added to intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr cause a rapid dissipation of the mitochondrial transmembrane potential (DeltaPsi(m)), as well as the mitochondrial release of apoptogenic proteins such as cytochrome c or apoptosis inducing factor [9].

Chemical compound and disease context of AIFM1


Biological context of AIFM1


Anatomical context of AIFM1


Associations of AIFM1 with chemical compounds


Physical interactions of AIFM1

  • In this work, we determined by deletional mutagenesis that a domain of AIF comprised between amino acids 150 and 228 is engaged in a molecular interaction with the substrate-binding domain of HSP70 [25].

Regulatory relationships of AIFM1


Other interactions of AIFM1

  • AIF mutants lacking the CypA-binding domain were inefficient apoptosis sensitizers in transfection experiments [15].
  • We show here that AICD in human melanoma epitope-specific primary CTL involves selective mitochondrio-nuclear translocation of the apoptosis inducing factor (AIF) without cytochrome c release, caspase-3 and caspase-8 activation, and results from large-scale DNA fragmentation [1].
  • While mitochondrial levels of AIF and endonuclease G were higher in TLE samples than controls, nuclear localization of AIF was limited and restricted to cells that were negative for cleaved caspase-3 [28].
  • The c-jun-N terminal kinase (JNK) inhibitor, SP600125, blocks the mitochondrio-nuclear translocation of AIF and prevents AICD in these CTL [1].
  • We conclude that DeltaPsi(m) loss and ROS production are an early step in CD47-dependent killing and neither cytochrome c, nor AIF are implicated in this new cell death pathway [29].

Analytical, diagnostic and therapeutic context of AIFM1


  1. Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. Chhabra, A., Mehrotra, S., Chakraborty, N.G., Dorsky, D.I., Mukherji, B. Eur. J. Immunol. (2006) [Pubmed]
  2. Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas. Gallego, M.A., Joseph, B., Hemström, T.H., Tamiji, S., Mortier, L., Kroemer, G., Formstecher, P., Zhivotovsky, B., Marchetti, P. Oncogene (2004) [Pubmed]
  3. CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells. Artus, C., Maquarre, E., Moubarak, R.S., Delettre, C., Jasmin, C., Susin, S.A., Robert-Lézénès, J. Oncogene (2006) [Pubmed]
  4. Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Ishitsuka, K., Hideshima, T., Hamasaki, M., Raje, N., Kumar, S., Podar, K., Le Gouill, S., Shiraishi, N., Yasui, H., Roccaro, A.M., Tai, Y.Z., Chauhan, D., Fram, R., Tamura, K., Jain, J., Anderson, K.C. Oncogene (2005) [Pubmed]
  5. OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Yacoub, A., Park, M.A., Hanna, D., Hong, Y., Mitchell, C., Pandya, A.P., Harada, H., Powis, G., Chen, C.S., Koumenis, C., Grant, S., Dent, P. Mol. Pharmacol. (2006) [Pubmed]
  6. Prodigiosin induces apoptosis by acting on mitochondria in human lung cancer cells. Llagostera, E., Soto-Cerrato, V., Montaner, B., Pérez-Tomás, R. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  7. Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease. Reix, S., Mechawar, N., Susin, S.A., Quirion, R., Krantic, S. Neurobiol. Aging (2007) [Pubmed]
  8. Apoptosis-inducing factor: vital and lethal. Modjtahedi, N., Giordanetto, F., Madeo, F., Kroemer, G. Trends Cell Biol. (2006) [Pubmed]
  9. The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Jacotot, E., Ravagnan, L., Loeffler, M., Ferri, K.F., Vieira, H.L., Zamzami, N., Costantini, P., Druillennec, S., Hoebeke, J., Briand, J.P., Irinopoulou, T., Daugas, E., Susin, S.A., Cointe, D., Xie, Z.H., Reed, J.C., Roques, B.P., Kroemer, G. J. Exp. Med. (2000) [Pubmed]
  10. Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. Rashmi, R., Santhosh Kumar, T.R., Karunagaran, D. FEBS Lett. (2003) [Pubmed]
  11. Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study. Strosznajder, R., Gajkowska, B. Acta neurobiologiae experimentalis. (2006) [Pubmed]
  12. Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. Braun, J.S., Sublett, J.E., Freyer, D., Mitchell, T.J., Cleveland, J.L., Tuomanen, E.I., Weber, J.R. J. Clin. Invest. (2002) [Pubmed]
  13. Role of caspases and apoptosis-inducing factor (AIF) in cladribine-induced apoptosis of B cell chronic lymphocytic leukemia. Pérez-Galán, P., Marzo, I., Giraldo, P., Rubio-Félix, D., Lasierra, P., Larrad, L., Anel, A., Naval, J. Leukemia (2002) [Pubmed]
  14. Allograft inflammatory factor-1 defines a distinct subset of infiltrating macrophages/microglial cells in rat and human gliomas. Deininger, M.H., Seid, K., Engel, S., Meyermann, R., Schluesener, H.J. Acta Neuropathol. (2000) [Pubmed]
  15. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Candé, C., Vahsen, N., Kouranti, I., Schmitt, E., Daugas, E., Spahr, C., Luban, J., Kroemer, R.T., Giordanetto, F., Garrido, C., Penninger, J.M., Kroemer, G. Oncogene (2004) [Pubmed]
  16. The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis. Yuste, V.J., Sánchez-López, I., Solé, C., Moubarak, R.S., Bayascas, J.R., Dolcet, X., Encinas, M., Susin, S.A., Comella, J.X. J. Biol. Chem. (2005) [Pubmed]
  17. Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. Zhang, Y., Zhang, X., Park, T.S., Gidday, J.M. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  18. Activation of dual apoptotic pathways in human melanocytes and protection by survivin. Liu, T., Biddle, D., Hanks, A.N., Brouha, B., Yan, H., Lee, R.M., Leachman, S.A., Grossman, D. J. Invest. Dermatol. (2006) [Pubmed]
  19. Inhibition of K(+) efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils. El Kebir, D., J??zsef, L., Khreiss, T., Filep, J.G. Cell. Signal. (2006) [Pubmed]
  20. Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G. Widlak, P., Garrard, W.T. J. Cell. Biochem. (2005) [Pubmed]
  21. Regulation of cytoplasmic stress granules by apoptosis-inducing factor. Candé, C., Vahsen, N., Métivier, D., Tourrière, H., Chebli, K., Garrido, C., Tazi, J., Kroemer, G. J. Cell. Sci. (2004) [Pubmed]
  22. Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. Zhang, C., Baffi, J., Cousins, S.W., Csaky, K.G. J. Cell. Sci. (2003) [Pubmed]
  23. Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Lemarié, A., Lagadic-Gossmann, D., Morzadec, C., Allain, N., Fardel, O., Vernhet, L. Free Radic. Biol. Med. (2004) [Pubmed]
  24. Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspase-independent cell death in the T cell line Jurkat. Murahashi, H., Azuma, H., Zamzami, N., Furuya, K.J., Ikebuchi, K., Yamaguchi, M., Yamada, Y., Sato, N., Fujihara, M., Kroemer, G., Ikeda, H. J. Leukoc. Biol. (2003) [Pubmed]
  25. Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Schmitt, E., Parcellier, A., Gurbuxani, S., Cande, C., Hammann, A., Morales, M.C., Hunt, C.R., Dix, D.J., Kroemer, R.T., Giordanetto, F., Jäättelä, M., Penninger, J.M., Pance, A., Kroemer, G., Garrido, C. Cancer Res. (2003) [Pubmed]
  26. Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment. Yacoub, A., Hawkins, W., Hanna, D., Young, H., Park, M.A., Grant, M., Roberts, J.D., Curiel, D.T., Fisher, P.B., Valerie, K., Grant, S., Hagan, M.P., Dent, P. Mol. Pharmacol. (2007) [Pubmed]
  27. HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Ruchalski, K., Mao, H., Singh, S.K., Wang, Y., Mosser, D.D., Li, F., Schwartz, J.H., Borkan, S.C. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  28. Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. Schindler, C.K., Pearson, E.G., Bonner, H.P., So, N.K., Simon, R.P., Prehn, J.H., Henshall, D.C. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  29. Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release. Roué, G., Bitton, N., Yuste, V.J., Montange, T., Rubio, M., Dessauge, F., Delettre, C., Merle-Béral, H., Sarfati, M., Susin, S.A. Biochimie (2003) [Pubmed]
  30. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. Daugas, E., Susin, S.A., Zamzami, N., Ferri, K.F., Irinopoulou, T., Larochette, N., Prévost, M.C., Leber, B., Andrews, D., Penninger, J., Kroemer, G. FASEB J. (2000) [Pubmed]
  31. Identification of apoptosis-inducing factor in human coronary artery endothelial cells. Zhang, W., Shokeen, M., Li, D., Mehta, J.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
WikiGenes - Universities