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Gene Review

Dnaja1  -  DnaJ (Hsp40) homolog, subfamily A, member 1

Rattus norvegicus

Synonyms: DnaJ homolog subfamily A member 1, DnaJ-like protein 1, HSJ-2, Heat shock protein J2, Hsj2, ...
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High impact information on Dnaja1

  • The predicted open reading frame encodes a protein of 242 amino acid residues whose sequence is similar to that of bacterial DnaJ proteins in the amino-terminal portion since it contains the highly conserved J domain which is present in all DnaJ-like proteins and is considered to have a critical role in DnaJ protein-protein interactions [1].
  • A DnaJ-like protein, RDJ1, was isolated from a rat brain cDNA library [2].
  • We identified a novel gene encoding a new member of the DnaJ family, JDD1 (J domain of DnaJ-like-protein 1), from the rat [3].
  • These cDNAs represent a variety of functional classes and include cytochrome oxidase, tubulin, Na(+)-K(+)-ATPase, spectrin, PEP-19, calmodulin, GTPase, DnaJ-like, clathrin-associated, synaptic glycoprotein, regulator of GTPase stimulation, and gene for oligodendrocyte lineage-myelin basic proteins [4].


  1. MSJ-1, a new member of the DNAJ family of proteins, is a male germ cell-specific gene product. Berruti, G., Perego, L., Borgonovo, B., Martegani, E. Exp. Cell Res. (1998) [Pubmed]
  2. Isolation and characterization of a DnaJ-like protein in rats: the C-terminal 10-kDa domain of hsc70 is not essential for stimulating the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein. Leng, C.H., Brodsky, J.L., Wang, C. Protein Sci. (1998) [Pubmed]
  3. JDD1, a novel member of the DnaJ family, is expressed in the germinal zone of the rat brain. Takamura, Y., Yagi, H., Hase, K., Yoneda, T., Maeda, M., Akagi, Y., Sato, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hyposmolality. Glasgow, E., Murase, T., Zhang, B., Verbalis, J.G., Gainer, H. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000) [Pubmed]
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