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Gene Review

Dnajc12  -  DnaJ (Hsp40) homolog, subfamily C, member 12

Rattus norvegicus

Synonyms: DnaJ homolog subfamily C member 12, J domain-containing protein 1, Jdp1
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Disease relevance of LOC619393

  • The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain [1].
  • Fragments containing the J-domain of RDJ1 either with or without the G/F motif were expressed in Escherichia coli [2].

High impact information on LOC619393

  • Cysteine string proteins (CSPs) are novel synaptic vesicle-associated protein components characterized by an N-terminal J-domain and a central palmitoylated string of cysteine residues [3].
  • This reaction requires the N-terminal binding site for pocket proteins and the J domain that binds chaperones [4].
  • This region contains a motif similar to the J domain, a conserved sequence found in the DnaJ family of molecular chaperones [1].
  • Cysteine string proteins (Csps) are J-domain chaperone proteins anchored at the surface of synaptic vesicles [5].
  • The N-terminal binding site of CSP, which includes the J domain, binds Galpha subunits but not Galphabeta subunits whereas the C terminal binding site of CSP associates with either free Galphabeta subunits or Galphabeta in complex with Galpha [6].

Biological context of LOC619393

  • This result suggested that either the structural or the functional integrity of the J domain is required to sensitize cells to apoptosis [7].
  • The predicted open reading frame encodes a protein of 242 amino acid residues whose sequence is similar to that of bacterial DnaJ proteins in the amino-terminal portion since it contains the highly conserved J domain which is present in all DnaJ-like proteins and is considered to have a critical role in DnaJ protein-protein interactions [8].
  • The reading frame encodes a protein of 223 amino acid residues containing J domain in the NH2 terminal region. rDJL gene is expressed mainly in testis and rDJL protein was immunolocalized notably in the acrosome region of spermatozoa [9].
  • The cloned JDD1 cDNA is 1689 bp in size and its deduced amino acid sequence consists of 259 amino acid residues [10].
  • JDD1 has a J domain that is unique to the DnaJ family but lacks the G/F region (a region that is rich in the amino acids glycine and phenylalanine) and the zinc finger region (also known as the cysteine-rich region)-both characteristic to the DnaJ [10].

Anatomical context of LOC619393

  • In the central nervous system, JDD1 mRNA expression is confined to the germinal (ventricular and subventricular) zone where, except for cells situated deepest in the ventricular zone, neurons and glias are generated and then differentiate during the embryonic period [10].

Other interactions of LOC619393


  1. The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Srinivasan, A., McClellan, A.J., Vartikar, J., Marks, I., Cantalupo, P., Li, Y., Whyte, P., Rundell, K., Brodsky, J.L., Pipas, J.M. Mol. Cell. Biol. (1997) [Pubmed]
  2. Isolation and characterization of a DnaJ-like protein in rats: the C-terminal 10-kDa domain of hsc70 is not essential for stimulating the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein. Leng, C.H., Brodsky, J.L., Wang, C. Protein Sci. (1998) [Pubmed]
  3. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. Brown, H., Larsson, O., Bränström, R., Yang, S.N., Leibiger, B., Leibiger, I., Fried, G., Moede, T., Deeney, J.T., Brown, G.R., Jacobsson, G., Rhodes, C.J., Braun, J.E., Scheller, R.H., Corkey, B.E., Berggren, P.O., Meister, B. EMBO J. (1998) [Pubmed]
  4. Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism. Nemethova, M., Smutny, M., Wintersberger, E. Mol. Cell. Biol. (2004) [Pubmed]
  5. Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel. Leveque, C., Pupier, S., Marqueze, B., Geslin, L., Kataoka, M., Takahashi, M., De Waard, M., Seagar, M. J. Biol. Chem. (1998) [Pubmed]
  6. Molecular determinants of cysteine string protein modulation of N-type calcium channels. Miller, L.C., Swayne, L.A., Kay, J.G., Feng, Z.P., Jarvis, S.E., Zamponi, G.W., Braun, J.E. J. Cell. Sci. (2003) [Pubmed]
  7. Simian virus 40 large T antigen and two independent T-antigen segments sensitize cells to apoptosis following genotoxic damage. Cole, S.L., Tevethia, M.J. J. Virol. (2002) [Pubmed]
  8. MSJ-1, a new member of the DNAJ family of proteins, is a male germ cell-specific gene product. Berruti, G., Perego, L., Borgonovo, B., Martegani, E. Exp. Cell Res. (1998) [Pubmed]
  9. Identification and characterization of rDJL, a novel member of the DnaJ protein family, in rat testis. Yang, C., Miao, S., Zong, S., Koide, S.S., Wang, L. FEBS Lett. (2005) [Pubmed]
  10. JDD1, a novel member of the DnaJ family, is expressed in the germinal zone of the rat brain. Takamura, Y., Yagi, H., Hase, K., Yoneda, T., Maeda, M., Akagi, Y., Sato, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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