Disease relevance of Dpysl5

• In retina, which expresses only GlyT1 but not GlyT2, Ulip6 was detected in the inner plexiform layer and along the somata and processes of selected bipolar, amacrine and ganglion cells [1].

High impact information on Dpysl5

• Our data support a model in which Ulip6 transiently interacts with GlyT2 in a phosphorylation-dependent manner [1].
• Subcellular fractionation of spinal cord and retina homogenates at different developmental stages showed Ulip6 immunoreactivity to be associated with light vesicles that were distinct from GlyT2-containing and synaptic vesicles [1].

Anatomical context of Dpysl5

• In pull-down assays and coimmunoprecipitation experiments with rat spinal cord extract, the presence of phosphatase inhibitors significantly enhanced binding of Ulip6 to GlyT2 [1].

Analytical, diagnostic and therapeutic context of Dpysl5

• Immunocytochemistry revealed punctate Ulip6 immunoreactivity in both somatic regions and processes of cultured spinal neurones; no colocalization with GlyT2 or other synaptic marker proteins was found [1].

References