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Gene Review

Dpysl5  -  dihydropyrimidinase-like 5

Rattus norvegicus

Synonyms: Crmp5, DRP-5, Dihydropyrimidinase-related protein 5, ULIP-6, UNC33-like phosphoprotein 6, ...
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Disease relevance of Dpysl5

  • In retina, which expresses only GlyT1 but not GlyT2, Ulip6 was detected in the inner plexiform layer and along the somata and processes of selected bipolar, amacrine and ganglion cells [1].

High impact information on Dpysl5

  • Our data support a model in which Ulip6 transiently interacts with GlyT2 in a phosphorylation-dependent manner [1].
  • Subcellular fractionation of spinal cord and retina homogenates at different developmental stages showed Ulip6 immunoreactivity to be associated with light vesicles that were distinct from GlyT2-containing and synaptic vesicles [1].

Anatomical context of Dpysl5

  • In pull-down assays and coimmunoprecipitation experiments with rat spinal cord extract, the presence of phosphatase inhibitors significantly enhanced binding of Ulip6 to GlyT2 [1].

Analytical, diagnostic and therapeutic context of Dpysl5

  • Immunocytochemistry revealed punctate Ulip6 immunoreactivity in both somatic regions and processes of cultured spinal neurones; no colocalization with GlyT2 or other synaptic marker proteins was found [1].


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