Disease relevance of MLVI4

• Provirus integration in this locus activates c-myc, and two additional genes, Mlvi-4 and Mlvi-1 [1].
• Human homologue of Moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3' of the myc gene, is rearranged in multiple myelomas [1].
• METHODS: The deletion mapping of chr.8p21.3-23 was done by 15 microsatellite markers and the alterations in the c-myc locus were analyzed by Southern hybridization using the pal-1/c-myc/mlvi-4/HPV 16/18 probes in seven cervical intraepithelial neoplasia (CIN) and 55 primary uterine cervical carcinoma [2].

High impact information on MLVI4

• The MLVI-4 locus represents the human homologue of the Moloney leukemia virus integration-4 locus (Mlvi-4), a common region for provirus integration in Moloney murine leukemia virus-induced T-cell lymphomas in rodents [1].
• Furthermore, rearrangements distal to the MYC gene, in the region of the MLVI-4 probe, may be less common than previously thought [3].
• The c-myc gene was activated by amplification/rearrangement at the pal-1/c-myc/mlvi-4 loci as well as HPV integration in the pal-1 locus in this tumor [2].

Analytical, diagnostic and therapeutic context of MLVI4

• The MYC alterations were analyzed by Southern blot using the pal-1/MYC/MLVI4 probes [4].

References