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Gene Review

MLVI4  -  Moloney leukemia virus integration site 4,...

Homo sapiens

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Disease relevance of MLVI4


High impact information on MLVI4

  • The MLVI-4 locus represents the human homologue of the Moloney leukemia virus integration-4 locus (Mlvi-4), a common region for provirus integration in Moloney murine leukemia virus-induced T-cell lymphomas in rodents [1].
  • Furthermore, rearrangements distal to the MYC gene, in the region of the MLVI-4 probe, may be less common than previously thought [3].
  • The c-myc gene was activated by amplification/rearrangement at the pal-1/c-myc/mlvi-4 loci as well as HPV integration in the pal-1 locus in this tumor [2].

Analytical, diagnostic and therapeutic context of MLVI4


  1. Human homologue of Moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3' of the myc gene, is rearranged in multiple myelomas. Palumbo, A.P., Boccadoro, M., Battaglio, S., Corradini, P., Tsichlis, P.N., Huebner, K., Pileri, A., Croce, C.M. Cancer Res. (1990) [Pubmed]
  2. Analysis of molecular alterations in chromosome 8 associated with the development of uterine cervical carcinoma of Indian patients. Bhattacharya, N., Singh, R.K., Mondal, S., Roy, A., Mondal, R., Roychowdhury, S., Panda, C.K. Gynecol. Oncol. (2004) [Pubmed]
  3. Proto-oncogene analysis in multiple myeloma. Ladanyi, M., Wang, S., Niesvizky, R., Feiner, H., Michaeli, J. Am. J. Pathol. (1992) [Pubmed]
  4. Approximately 580 Kb surrounding the MYC gene is amplified in head and neck squamous cell carcinoma of Indian patients. Bhattacharya, N., Sabbir, M.G., Roy, A., Dam, A., Roychoudhury, S., Panda, C.K. Pathol. Res. Pract. (2005) [Pubmed]
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