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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, myc

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Disease relevance of Genes, myc


High impact information on Genes, myc

  • We defined how, in the same context, Smad3 can also mediate transcriptional repression of the growth-promoting gene c-myc [6].
  • The TCF-4 target gene c-MYC plays a central role in this switch by direct repression of the p21(CIP1/WAF1) promoter [7].
  • We suggest that expression of both activated ras and myc genes bypasses the need for p53 mutation by neutralizing the tumor suppressor activity of normal p53 [8].
  • These observations indicate that pRB or another protein that interacts with this binding domain mediates TGF-beta 1 regulation of c-myc gene expression and growth inhibition [9].
  • Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ [10].

Chemical compound and disease context of Genes, myc


Biological context of Genes, myc


Anatomical context of Genes, myc


Associations of Genes, myc with chemical compounds

  • The requirements for increased expression of c-myc mRNA by cycloheximide are the presence of the sequence encoding c-myc amino acids 335-439 on a mRNA that can be translated; all other portions of the c-myc gene are dispensable, and this sequence can confer induction of mRNA expression by protein synthesis inhibitors on a heterologous gene [26].
  • Pre-implantation embryos were infected with the retroviral vector MMCV-neo, which carries the neomycin resistance (neo) gene and the v-myc gene [27].
  • These two pathways, which can be activated by phorbol myristate acetate (PMA) and ionomycin respectively, appear to play complementary roles in the transcriptional induction of c-myc gene expression by the antigen receptor complex [28].
  • P493-6 cells, when grown in the presence of estrogen with the exogenous c-myc gene switched off, were strongly immunogenic [29].
  • We compared the effects of HU, as well as two other known differentiating agents (dimethyl sulfoxide and retinoic acid), on c-myc gene copy number, c-myc expression, and differentiation in HL60 cells containing amplified c-myc genes either on DMs or HSRs [30].

Gene context of Genes, myc


Analytical, diagnostic and therapeutic context of Genes, myc


  1. The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Battey, J., Moulding, C., Taub, R., Murphy, W., Stewart, T., Potter, H., Lenoir, G., Leder, P. Cell (1983) [Pubmed]
  2. Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas. Shen-Ong, G.L., Keath, E.J., Piccoli, S.P., Cole, M.D. Cell (1982) [Pubmed]
  3. Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Rapp, U.R., Cleveland, J.L., Brightman, K., Scott, A., Ihle, J.N. Nature (1985) [Pubmed]
  4. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Kohl, N.E., Legouy, E., DePinho, R.A., Nisen, P.D., Smith, R.K., Gee, C.E., Alt, F.W. Nature (1986) [Pubmed]
  5. Complementation of transforming domains in E1a/myc chimaeras. Ralston, R. Nature (1991) [Pubmed]
  6. E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Chen, C.R., Kang, Y., Siegel, P.M., Massagué, J. Cell (2002) [Pubmed]
  7. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.P., Tjon-Pon-Fong, M., Moerer, P., van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. Cell (2002) [Pubmed]
  8. Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation. Lu, X., Park, S.H., Thompson, T.C., Lane, D.P. Cell (1992) [Pubmed]
  9. TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Pietenpol, J.A., Stein, R.W., Moran, E., Yaciuk, P., Schlegel, R., Lyons, R.M., Pittelkow, M.R., Münger, K., Howley, P.M., Moses, H.L. Cell (1990) [Pubmed]
  10. Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ. Thompson, T.C., Southgate, J., Kitchener, G., Land, H. Cell (1989) [Pubmed]
  11. Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum. Saksela, K., Mäkelä, T.P., Evan, G., Alitalo, K. EMBO J. (1989) [Pubmed]
  12. Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Hoshimaru, M., Ray, J., Sah, D.W., Gage, F.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Mechanism of all-trans-retinoic acid-mediated L-myc gene regulation in small cell lung cancer. Ou, X., Campau, S., Slusher, R., Jasti, R.K., Mabry, M., Kalemkerian, G.P. Oncogene (1996) [Pubmed]
  14. Insufficiency of transformation by simian virus 40, polyomavirus, EJ-ras, or v-myc oncogenes for conversion of ethanolamine-responsive mammary cells to ethanolamine-nonresponsive cells. Kano-Sueoka, T., King, D.M. J. Virol. (1988) [Pubmed]
  15. Inverse expression of mdr 1 and c-myc genes in a rhabdomyosarcoma cell line resistant to actinomycin d. Prados, J., Melguizo, C., Fernández, A., Aránega, A.E., Alvarez, L., Aránega, A. J. Pathol. (1996) [Pubmed]
  16. Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma. Corcoran, L.M., Cory, S., Adams, J.M. Cell (1985) [Pubmed]
  17. The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia. Diaz, M.O., Le Beau, M.M., Rowley, J.D., Drabkin, H.A., Patterson, D. Science (1985) [Pubmed]
  18. A point mutation in the c-myc locus of a Burkitt lymphoma abolishes binding of a nuclear protein. Zajac-Kaye, M., Gelmann, E.P., Levens, D. Science (1988) [Pubmed]
  19. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Stanton, B.R., Perkins, A.S., Tessarollo, L., Sassoon, D.A., Parada, L.F. Genes Dev. (1992) [Pubmed]
  20. Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A. Granelli-Piperno, A., Andrus, L., Steinman, R.M. J. Exp. Med. (1986) [Pubmed]
  21. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Ren, B., Chee, K.J., Kim, T.H., Maniatis, T. Genes Dev. (1999) [Pubmed]
  22. High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice. Möröy, T., Fisher, P.E., Lee, G., Achacoso, P., Wiener, F., Alt, F.W. J. Exp. Med. (1992) [Pubmed]
  23. c-myc gene inactivation during induced maturation of HL-60 cells. Transcriptional repression and loss of a specific DNAse I hypersensitive site. High, K.A., Stolle, C.A., Schneider, J.W., Hu, W., Benz, E.J. J. Clin. Invest. (1987) [Pubmed]
  24. Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells. Tuan, D., London, I.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  25. Differential promoter utilization by the c-myc gene in mitogen- and interleukin-2-stimulated human lymphocytes. Broome, H.E., Reed, J.C., Godillot, E.P., Hoover, R.G. Mol. Cell. Biol. (1987) [Pubmed]
  26. The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Wisdom, R., Lee, W. Genes Dev. (1991) [Pubmed]
  27. Expression of retroviral vectors in transgenic mice obtained by embryo infection. Stewart, C.L., Schuetze, S., Vanek, M., Wagner, E.F. EMBO J. (1987) [Pubmed]
  28. Multiple mechanisms regulate c-myc gene expression during normal T cell activation. Lindsten, T., June, C.H., Thompson, C.B. EMBO J. (1988) [Pubmed]
  29. MYC overexpression imposes a nonimmunogenic phenotype on Epstein-Barr virus-infected B cells. Staege, M.S., Lee, S.P., Frisan, T., Mautner, J., Scholz, S., Pajic, A., Rickinson, A.B., Masucci, M.G., Polack, A., Bornkamm, G.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Eckhardt, S.G., Dai, A., Davidson, K.K., Forseth, B.J., Wahl, G.M., Von Hoff, D.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  31. ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast. Schuldiner, O., Eden, A., Ben-Yosef, T., Yanuka, O., Simchen, G., Benvenisty, N. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  32. Malignant transformation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene. Hurlin, P.J., Maher, V.M., McCormick, J.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  33. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Filippova, G.N., Fagerlie, S., Klenova, E.M., Myers, C., Dehner, Y., Goodwin, G., Neiman, P.E., Collins, S.J., Lobanenkov, V.V. Mol. Cell. Biol. (1996) [Pubmed]
  34. Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation. Kirito, K., Nakajima, K., Watanabe, T., Uchida, M., Tanaka, M., Ozawa, K., Komatsu, N. Blood (2002) [Pubmed]
  35. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. Kapila, Y.L., Wang, S., Dazin, P., Tafolla, E., Mass, M.J. J. Biol. Chem. (2002) [Pubmed]
  36. Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations. Cesarman, E., Chadburn, A., Inghirami, G., Gaidano, G., Knowles, D.M. Blood (1992) [Pubmed]
  37. Recruitment of distinct chromatin-modifying complexes by tamoxifen-complexed estrogen receptor at natural target gene promoters in vivo. Liu, X.F., Bagchi, M.K. J. Biol. Chem. (2004) [Pubmed]
  38. Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death. Lee, Y.J., Galoforo, S.S., Berns, C.M., Tong, W.P., Kim, H.R., Corry, P.M. J. Cell. Sci. (1997) [Pubmed]
  39. Expression of the myc proto-oncogenes in developing human fetal brain. Hirvonen, H., Mäkelä, T.P., Sandberg, M., Kalimo, H., Vuorio, E., Alitalo, K. Oncogene (1990) [Pubmed]
  40. gag as well as myc sequences contribute to the transforming phenotype of the avian retrovirus FH3. Tikhonenko, A.T., Linial, M.L. J. Virol. (1992) [Pubmed]
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