Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SPIB - Spi-B transcription factor (Spi-1/PU.1...

Homo sapiens

Synonyms: SPI-B, Transcription factor Spi-B

Bartholdy, B. et al., Yamamoto, H. et al., Lenz, G. et al., Dekoninck, A. et al., Schotte, R. et al., et al.

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High impact information on SPIB

Accordingly, aberrant switch recombination was responsible for translocations in ABC DLBCLs involving BCL6, MYC, and a novel translocation partner, SPIB [1].
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development [2].
Using microarray analysis, we have identified the Ets transcription factor Spi-B as a direct target gene critically regulated by OBF-1 that can help explain the phenotype of OBF-1-deficient mice [3].
The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development [4].
We demonstrated by gel shift and supershift assays that PU.1 and the related Ets transcription factor Spi-B interacted specifically with this PUbox [5].

Other interactions of SPIB

Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb [6].

References

Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. Lenz, G., Nagel, I., Siebert, R., Roschke, A.V., Sanger, W., Wright, G.W., Dave, S.S., Tan, B., Zhao, H., Rosenwald, A., Muller-Hermelink, H.K., Gascoyne, R.D., Campo, E., Jaffe, E.S., Smeland, E.B., Fisher, R.I., Kuehl, W.M., Chan, W.C., Staudt, L.M. J. Exp. Med. (2007) [Pubmed]
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. Schotte, R., Nagasawa, M., Weijer, K., Spits, H., Blom, B. J. Exp. Med. (2004) [Pubmed]
The Ets factor Spi-B is a direct critical target of the coactivator OBF-1. Bartholdy, B., Du Roure, C., Bordon, A., Emslie, D., Corcoran, L.M., Matthias, P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. Schotte, R., Rissoan, M.C., Bendriss-Vermare, N., Bridon, J.M., Duhen, T., Weijer, K., Brière, F., Spits, H. Blood (2003) [Pubmed]
Identification and characterization of a PU.1/Spi-B binding site in the bovine leukemia virus long terminal repeat. Dekoninck, A., Calomme, C., Nizet, S., de Launoit, Y., Burny, A., Ghysdael, J., Van Lint, C. Oncogene (2003) [Pubmed]
Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. Yamamoto, H., Kihara-Negishi, F., Yamada, T., Suzuki, M., Nakano, T., Oikawa, T. Cell Growth Differ. (2002) [Pubmed]

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