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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pbrm1  -  polybromo 1

Mus musculus

Synonyms: 2310032M22Rik, 2610016F04Rik, AI507524, BAF180, BRG1-associated factor 180, ...
 
 
 
 
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High impact information on Pbrm1

  • Importantly, BAF180 is recruited to the promoter of these target genes and BAF180 deficiency affects the RA response for CRABPII and RARbeta2 [1].
  • Here we show that the ablation of PBAF-specific subunit BAF180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placental defects, similar to those found in mice lacking RXRalpha and PPARgamma [1].
  • Embryonic aggregation analyses reveal that in contrast to PPARgamma-deficient mice, the heart defects are likely a direct result of BAF180 ablation, rather than an indirect consequence of trophoblast placental defects [1].
  • We identified potential target genes for BAF180 in heart development, such as S100A13 as well as retinoic acid (RA)-induced targets RARbeta2 and CRABPII [1].

References

  1. Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Wang, Z., Zhai, W., Richardson, J.A., Olson, E.N., Meneses, J.J., Firpo, M.T., Kang, C., Skarnes, W.C., Tjian, R. Genes Dev. (2004) [Pubmed]
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