Gene Review:
Rxra - retinoid X receptor alpha
Mus musculus
Synonyms:
9530071D11Rik, Nr2b1, Nuclear receptor subfamily 2 group B member 1, RXR alpha 1, RXRalpha1, ...
- Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Imai, T., Jiang, M., Chambon, P., Metzger, D. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice. Wan, Y.J., Cai, Y., Lungo, W., Fu, P., Locker, J., French, S., Sucov, H.M. J. Biol. Chem. (2000)
- Reduction of both RAR and RXR levels is required to maximally alter sensitivity of CA-OV3 ovarian tumor cells to growth suppression by all-trans-retinoic acid. Wu, S., Zhang, Z.P., Zhang, D., Soprano, D.R., Soprano, K.J. Exp. Cell Res. (1997)
- Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis. Nagao, Y., French, B.A., Cai, Y., French, S.W., Wan, Y.J. J. Cell. Biochem. (1998)
- Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids. Peng, X., Yun, D., Christov, K. Int. J. Oncol. (2004)
- Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. McNamara, P., Seo, S.P., Rudic, R.D., Sehgal, A., Chakravarti, D., FitzGerald, G.A. Cell (2001)
- Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Kastner, P., Grondona, J.M., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J.L., Dollé, P., Chambon, P. Cell (1994)
- Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Li, M., Indra, A.K., Warot, X., Brocard, J., Messaddeq, N., Kato, S., Metzger, D., Chambon, P. Nature (2000)
- RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells. Lin, X.F., Zhao, B.X., Chen, H.Z., Ye, X.F., Yang, C.Y., Zhou, H.Y., Zhang, M.Q., Lin, S.C., Wu, Q. J. Cell. Sci. (2004)
- Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Wu, Y., Zhang, X., Bardag-Gorce, F., Robel, R.C., Aguilo, J., Chen, L., Zeng, Y., Hwang, K., French, S.W., Lu, S.C., Wan, Y.J. Mol. Pharmacol. (2004)
- Hepatocyte retinoid X receptor-alpha-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance. Wan, Y.J., Han, G., Cai, Y., Dai, T., Konishi, T., Leng, A.S. Endocrinology (2003)
- The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Cai, Y., Konishi, T., Han, G., Campwala, K.H., French, S.W., Wan, Y.J. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2002)
- Retinoid receptor-dependent and -independent effects of N-(4-hydroxyphenyl)retinamide in F9 embryonal carcinoma cells. Clifford, J.L., Menter, D.G., Wang, M., Lotan, R., Lippman, S.M. Cancer Res. (1999)
- Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Kubalak, S.W., Hutson, D.R., Scott, K.K., Shannon, R.A. Development (2002)
- Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo. Dilworth, F.J., Fromental-Ramain, C., Remboutsika, E., Benecke, A., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects. Sucov, H.M., Izpisúa-Belmonte, J.C., Gañan, Y., Evans, R.M. Development (1995)
- Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Wan, Y.J., An, D., Cai, Y., Repa, J.J., Hung-Po Chen, T., Flores, M., Postic, C., Magnuson, M.A., Chen, J., Chien, K.R., French, S., Mangelsdorf, D.J., Sucov, H.M. Mol. Cell. Biol. (2000)
- Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes. Mori, M., Ghyselinck, N.B., Chambon, P., Mark, M. Invest. Ophthalmol. Vis. Sci. (2001)
- Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene. Frohnert, B.I., Hui, T.Y., Bernlohr, D.A. J. Biol. Chem. (1999)
- Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear. Romand, R., Sapin, V., Dollé, P. J. Comp. Neurol. (1998)
- In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha. Tanaka, N., Hora, K., Makishima, H., Kamijo, Y., Kiyosawa, K., Gonzalez, F.J., Aoyama, T. FEBS Lett. (2003)
- Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors. Muscat, G.E., Mynett-Johnson, L., Dowhan, D., Downes, M., Griggs, R. Nucleic Acids Res. (1994)
- Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter. Palmer, C.N., Hsu, M.H., Muerhoff, A.S., Griffin, K.J., Johnson, E.F. J. Biol. Chem. (1994)
- Cytosolic and nuclear distribution of PPARgamma2 in differentiating 3T3-L1 preadipocytes. Thuillier, P., Baillie, R., Sha, X., Clarke, S.D. J. Lipid Res. (1998)
- Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains. Hallenbeck, P.L., Minucci, S., Lippoldt, R., Phyillaier, M., Horn, V., Ozato, K., Nikodem, V.M. J. Biol. Chem. (1996)
- PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Tontonoz, P., Hu, E., Devine, J., Beale, E.G., Spiegelman, B.M. Mol. Cell. Biol. (1995)
- Studies of the effects of 1,25-dihydroxyvitamin D on skeletal and calcium homeostasis and on inhibition of tumor cell growth. Goltzman, D., White, J., Kremer, R. J. Steroid Biochem. Mol. Biol. (2001)
- Acetyl-CoA carboxylase beta expression mediated by MyoD and muscle regulatory factor 4 is differentially affected by retinoic acid receptor and retinoid X receptor. Kim, J.Y., Lee, J.J., Kim, K.S. Exp. Mol. Med. (2003)
- Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: The role of a gene enhancer in the liver chromatin. Seo, Y.K., Chung, Y.T., Kim, S., Echchgadda, I., Song, C.S., Chatterjee, B. Gene (2007)
- Retinoic acid administration and vitamin A status modulate retinoid X receptor alpha and retinoic acid receptor alpha levels in mouse brown adipose tissue. Ribot, J., Felipe, F., Bonet, M.L., Palou, A. Mol. Cell. Biochem. (2004)
- Thyroid hormone receptors bind to the promoter of the mouse histone H10 gene and modulate its transcription. Bauer-Hofmann, R., Alonso, A. Nucleic Acids Res. (1995)
- Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. Kamei, Y., Kawada, T., Kazuki, R., Sugimoto, E. Biochem. J. (1993)
- Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation. Pogenberg, V., Guichou, J.F., Bourguet, W. Acta Crystallogr. D Biol. Crystallogr. (2004)