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PBRM1  -  polybromo 1

Gallus gallus

 
 
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Disease relevance of PBRM1

  • Additionally, A/Chicken/HK/G9/97 (H9N2) virus has PB1 and PB2 genes that are highly related to those of A/HK/156/97 (H5N1), A/Teal/HK/W312/97 (H6N1), and A/Quail/HK/G1/97 (H9N2) viruses [1].
  • The H6N2 NS1 and PB1 genes shared recent common ancestors with those of contemporary Asian HPAI H5N1 viruses [2].
  • Genetic analysis of mouse-adapted influenza A virus identifies roles for the NA, PB1, and PB2 genes in virulence [3].
 

High impact information on PBRM1

  • Basal and drug-inducible PB1 P-450 mRNA levels were unaffected by haem or by inhibitors of haem biosynthesis, indicating that the PB1 P-450 gene is not regulated by haem in chick embryo hepatocytes [4].
  • Cycloheximide treatment alone did not significantly affect ALA synthase mRNA expression, but induced PB1 P-450 mRNA to a similar extent to that caused by porphyrinogenic drugs, suggesting the presence of a labile repressor which modulates PB1 P-450 gene expression [4].
  • We found that the mRNAs for ALA synthase and PB1 P-450 were rapidly and simultaneously induced by the porphyrinogenic drugs glutethimide and 2-propyl-2-isopropylacetamide [4].
  • In contrast, chromium(VI) treatment had significant but opposite effects on the basal and drug-inducible expression of 5-aminolevulinate synthase and cytochrome PB1 P450 [5].
  • The M1, M2, and PB1-F2 protein sequences from the strains were identical [6].
 

Anatomical context of PBRM1

  • Virus-induced polypeptide synthesis in chick embryo fibroblast cells was confined to the synthesis of PB2, PB1 and PA subunits of the RNA dependent-RNA polymerase, the nucleoprotein NP, the non-structural protein NS1, the haemagglutinin HA, the non-structural protein NS2; only the membrane M1 polypeptide synthesis was greatly inhibited [7].
 

Associations of PBRM1 with chemical compounds

  • The molecular function of polybromo itself also remains unclear, but it has been identified as a key component of an SWI/SNF (switching/sucrose non-fermenting)-related, ATP-dependent chromatin-remodelling complex PBAF (polybromo, BRG1-associated factors; also known as SWI/SNF-B or SWI/SNFbeta) [8].
 

Analytical, diagnostic and therapeutic context of PBRM1

  • Molecular cloning of polybromo, a nuclear protein containing multiple domains including five bromodomains, a truncated HMG-box, and two repeats of a novel domain [9].
  • Gel filtration analysis of nuclear extracts demonstrate that polybromo is part of a large complex with a mass of approximately 2 million dalton [9].
  • Antibodies that were raised against polybromo were used in confocal microscopy analysis to show that the 180-kDa polybromo protein is located within the nucleus but excluded from the nucleolus [9].

References

  1. Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals. Leneva, I.A., Goloubeva, O., Fenton, R.J., Tisdale, M., Webster, R.G. Antimicrob. Agents Chemother. (2001) [Pubmed]
  2. Outbreaks of avian influenza H6N2 viruses in chickens arose by a reassortment of H6N8 and H9N2 ostrich viruses. Abolnik, C., Bisschop, S., Gerdes, T., Olivier, A., Horner, R. Virus Genes (2007) [Pubmed]
  3. Genetic analysis of mouse-adapted influenza A virus identifies roles for the NA, PB1, and PB2 genes in virulence. Brown, E.G., Bailly, J.E. Virus Res. (1999) [Pubmed]
  4. Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem. Hamilton, J.W., Bement, W.J., Sinclair, P.R., Sinclair, J.F., Wetterhahn, K.E. Biochem. J. (1988) [Pubmed]
  5. Differential effects of chromium(VI) on constitutive and inducible gene expression in chick embryo liver in vivo and correlation with chromium(VI)-induced DNA damage. Hamilton, J.W., Wetterhahn, K.E. Mol. Carcinog. (1989) [Pubmed]
  6. Sequence comparison between two quasi strains of H6N1 with different pathogenicity from a single parental isolate. Hsu, C.N., Wang, C.H. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. (2006) [Pubmed]
  7. Chromomycin A3 inhibits influenza a virus multiplication in chick embryo fibroblast cells. Conti, G., Portincasa, P. New Microbiol. (2002) [Pubmed]
  8. Crystal structure of the proximal BAH domain of the polybromo protein. Oliver, A.W., Jones, S.A., Roe, S.M., Matthews, S., Goodwin, G.H., Pearl, L.H. Biochem. J. (2005) [Pubmed]
  9. Molecular cloning of polybromo, a nuclear protein containing multiple domains including five bromodomains, a truncated HMG-box, and two repeats of a novel domain. Nicolas, R.H., Goodwin, G.H. Gene (1996) [Pubmed]
 
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