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Gene Review:

Bbs2 - Bardet-Biedl syndrome 2 (human)

Mus musculus

Synonyms: 2410125H22Rik, AI447581, Bardet-Biedl syndrome 2 protein homolog

Nishimura, D.Y. et al.

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Disease relevance of Bbs2

We show that mice lacking Bbs2 gene expression have major components of the human phenotype, including obesity and retinopathy [1].
The evaluation of Bbs2(-/-) mice indicates additional phenotypes that should be evaluated in human patients, including deficits in social interaction and infertility [1].

Psychiatry related information on Bbs2

Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin [1].

References

Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Nishimura, D.Y., Fath, M., Mullins, R.F., Searby, C., Andrews, M., Davis, R., Andorf, J.L., Mykytyn, K., Swiderski, R.E., Yang, B., Carmi, R., Stone, E.M., Sheffield, V.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP009637	Anopheles gambiae str. PEST
BBS2	Bos taurus
bbs-2	Caenorhabditis elegans
BBS2	Canis lupus familiaris
bbs2	Danio rerio
BBS2	Gallus gallus
BBS2	Homo sapiens
BBS2	Macaca mulatta
BBS2	Pan troglodytes
Bbs2	Rattus norvegicus
LOC100493660	Xenopus (Silurana) tropicalis

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