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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Interpersonal Relations

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Disease relevance of Interpersonal Relations


Psychiatry related information on Interpersonal Relations

  • RESULTS: We show here that Thy-1 null mice are unable to make the appropriate dietary choice in the test for social transmission of food preference, despite showing a normal level of social interaction with the demonstrator mouse, normal neophobia, and normal learning in a T-maze using scented food as cues [6].
  • Motor activity and social interaction scores of the EGF-treated animals were also impaired in adult rats, though not in earlier developmental stages [7].
  • Given the significance of central nucleus of the amygdala in social behavior, oxytocin was infused into the central nucleus of experimental and control male rats, and their postinfusion social interaction and open field behaviors were analyzed [8].
  • CONCLUSION: Paroxetine, 20 mg/day, is an effective and safe treatment for patients with generalized social anxiety disorder and significantly improves social anxiety, avoidance of social interactions, social disability, and overall clinical condition [9].
  • Intravenous pentagastrin and placebo were administered in a double-blind fashion to 19 social phobics, 11 patients with panic disorder, and 19 healthy controls while they participated in a structured social interaction task [10].

High impact information on Interpersonal Relations


Chemical compound and disease context of Interpersonal Relations

  • These rats show a reduced propensity for social interaction, increased anxiety in intimidating or novel situations and a reduction in cerebral asymmetry and dopamine turnover, consistent with those in schizophrenic humans [15].
  • However, 100 mg/kg i.p. tryptophan 60 min before the test reduced the social interaction and aggressive behavior of the STZ-D mice but increased these behaviors in controls [16].
  • CONCLUSIONS: Risperidone led to significant improvements in the restricted, repetitive, and stereotyped patterns of behavior, interests, and activities of autistic children but did not significantly change their deficit in social interaction and communication [17].
  • In animals, NMDA antagonist-induced behavioral responses include increased activity, head weaving, deficits in paired pulse inhibition and social interaction, and increased forced swim immobility [18].
  • Some effects of amphetamine (e.g., suppression of social interaction) are not reversed by haloperidol, and some effects of withdrawal of haloperidol (e.g., precipitation of checking movements not present when haloperidol was commenced) do not have an obvious counterpart in the clinical situation [19].

Biological context of Interpersonal Relations


Anatomical context of Interpersonal Relations


Gene context of Interpersonal Relations

  • In contrast, we found elevated levels of anxiety in DBA/2J-Penk1(-/-) mice only in the zero-maze and social interaction tests [30].
  • When microinjected into the BLA, we found Ucn was substantially more potent than CRF in producing anxiogenic-like behavior as assessed in the social interaction test [31].
  • This behavioral effect may be mediated by estrogen-induced increases in OT binding density in the lateral septum and may be important to the facilitation of social interactions [32].
  • Thus, administration of GRF to patients with early onset SDAT has been followed by a significant improvement in locomotion, appetite, mental performance and social interaction [33].
  • To investigate the mechanism underlying the deficits in social behavior induced by blockade of N-methyl-D-aspartate (NMDA) receptors, this study examined the effect of noncompetitive NMDA antagonists on AVP receptor binding and social interaction in the rat [34].

Analytical, diagnostic and therapeutic context of Interpersonal Relations


  1. Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Nishimura, D.Y., Fath, M., Mullins, R.F., Searby, C., Andrews, M., Davis, R., Andorf, J.L., Mykytyn, K., Swiderski, R.E., Yang, B., Carmi, R., Stone, E.M., Sheffield, V.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction. Neigh, G.N., Kofler, J., Meyers, J.L., Bergdall, V., La Perle, K.M., Traystman, R.J., DeVries, A.C. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  3. Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. Roy, M., David, N.K., Danao, J.V., Baribault, H., Tian, H., Giorgetti, M. Neuropsychopharmacology (2006) [Pubmed]
  4. Life-spanning behavioural and adrenal dysfunction induced by prenatal hypoxia in the rat is prevented by the calcium antagonist nimodipine. Nyakas, C., Buwalda, B., Markel, E., Korte, S.M., Luiten, P.G. Eur. J. Neurosci. (1994) [Pubmed]
  5. Endotoxin produces a depressive-like episode in rats. Yirmiya, R. Brain Res. (1996) [Pubmed]
  6. Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food. Mayeux-Portas, V., File, S.E., Stewart, C.L., Morris, R.J. Curr. Biol. (2000) [Pubmed]
  7. Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development. Futamura, T., Kakita, A., Tohmi, M., Sotoyama, H., Takahashi, H., Nawa, H. Mol. Psychiatry (2003) [Pubmed]
  8. Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin. Lee, P.R., Brady, D.L., Shapiro, R.A., Dorsa, D.M., Koenig, J.I. Neuropsychopharmacology (2005) [Pubmed]
  9. A randomized, double-blind, fixed-dose comparison of paroxetine and placebo in the treatment of generalized social anxiety disorder. Liebowitz, M.R., Stein, M.B., Tancer, M., Carpenter, D., Oakes, R., Pitts, C.D. The Journal of clinical psychiatry. (2002) [Pubmed]
  10. A comparison of the effects of intravenous pentagastrin on patients with social phobia, panic disorder and healthy controls. McCann, U.D., Slate, S.O., Geraci, M., Roscow-Terrill, D., Uhde, T.W. Neuropsychopharmacology (1997) [Pubmed]
  11. Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Lijam, N., Paylor, R., McDonald, M.P., Crawley, J.N., Deng, C.X., Herrup, K., Stevens, K.E., Maccaferri, G., McBain, C.J., Sussman, D.J., Wynshaw-Boris, A. Cell (1997) [Pubmed]
  12. Pten and the Brain: Sizing up Social Interaction. Greer, J.M., Wynshaw-Boris, A. Neuron (2006) [Pubmed]
  13. Differential effects of diazepam and pentobarbital on mood and behavior. Griffiths, R.R., Bigelow, G.E., Liebson, I. Arch. Gen. Psychiatry (1983) [Pubmed]
  14. The effects of methylphenidate on the mother-child interactions of hyperactive children. Barkley, R.A., Cunningham, C.E. Arch. Gen. Psychiatry (1979) [Pubmed]
  15. Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Weinstock, M. Prog. Neurobiol. (2001) [Pubmed]
  16. Effects of tryptophan on depression and aggression in STZ-D mice. Hilakivi-Clarke, L.A. Diabetes (1991) [Pubmed]
  17. Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology. McDougle, C.J., Scahill, L., Aman, M.G., McCracken, J.T., Tierney, E., Davies, M., Arnold, L.E., Posey, D.J., Martin, A., Ghuman, J.K., Shah, B., Chuang, S.Z., Swiezy, N.B., Gonzalez, N.M., Hollway, J., Koenig, K., McGough, J.J., Ritz, L., Vitiello, B. The American journal of psychiatry. (2005) [Pubmed]
  18. Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness. Breese, G.R., Knapp, D.J., Moy, S.S. Neuroscience and biobehavioral reviews. (2002) [Pubmed]
  19. The time course of the behavioral effects of amphetamine and their reversal by haloperidol in a primate species. Ridley, R.M., Baker, H.F., Scraggs, P.R. Biol. Psychiatry (1979) [Pubmed]
  20. The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Scraggs, P.R., Ridley, R.M. Psychopharmacology (Berl.) (1979) [Pubmed]
  21. A mouse model of early social interactions after prenatal drug exposure: a genetic investigation. Laviola, G., Terranova, M.L., Sedowofia, K., Clayton, R., Manning, A. Psychopharmacology (Berl.) (1994) [Pubmed]
  22. MDMA ("ecstasy"), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat. Clemens, K.J., Van Nieuwenhuyzen, P.S., Li, K.M., Cornish, J.L., Hunt, G.E., McGregor, I.S. Psychopharmacology (Berl.) (2004) [Pubmed]
  23. Psychologic stress increases plasma levels of prolactin, cortisol, and POMC-derived peptides in man. Meyerhoff, J.L., Oleshansky, M.A., Mougey, E.H. Psychosomatic medicine. (1988) [Pubmed]
  24. A multiple-test study of anxiety-related behaviours in six inbred rat strains. Ramos, A., Berton, O., Mormède, P., Chaouloff, F. Behav. Brain Res. (1997) [Pubmed]
  25. Protein kinase A activation increases sodium current magnitude in the electric organ of Sternopygus. McAnelly, L., Zakon, H.H. J. Neurosci. (1996) [Pubmed]
  26. Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Hamon, M., Doucet, E., Lefèvre, K., Miquel, M.C., Lanfumey, L., Insausti, R., Frechilla, D., Del Rio, J., Vergé, D. Neuropsychopharmacology (1999) [Pubmed]
  27. Anxiogenic effects of nicotine in the dorsal hippocampus are mediated by 5-HT1A and not by muscarinic M1 receptors. Kenny, P.J., Cheeta, S., File, S.E. Neuropharmacology (2000) [Pubmed]
  28. Contrasting behavioural effects of 8-OH DPAT in the dorsal raphé nucleus and ventral hippocampus. Hogg, S., Andrews, N., File, S.E. Neuropharmacology (1994) [Pubmed]
  29. Behavioral and mesocorticolimbic dopamine responses to non aggressive social interactions depend on previous social experiences and on the opponent's sex. Cabib, S., D'Amato, F.R., Puglisi-Allegra, S., Maestripieri, D. Behav. Brain Res. (2000) [Pubmed]
  30. Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds. Bilkei-Gorzo, A., Racz, I., Michel, K., Zimmer, A., Klingmüller, D., Zimmer, A. Psychopharmacology (Berl.) (2004) [Pubmed]
  31. Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses. Sajdyk, T.J., Schober, D.A., Gehlert, D.R., Shekhar, A. Behav. Brain Res. (1999) [Pubmed]
  32. An anxiolytic action of oxytocin is enhanced by estrogen in the mouse. McCarthy, M.M., McDonald, C.H., Brooks, P.J., Goldman, D. Physiol. Behav. (1996) [Pubmed]
  33. Influence of somatostatin and growth hormone-releasing factor on behavior. Clinical and therapeutic implications in neuropsychiatric disorders. Cacabelos, R., Niigawa, H., Rodriguez-Arnao, M.D., Gómez-Pan, A., Nishimura, T. Horm. Res. (1988) [Pubmed]
  34. Subchronic phencyclidine administration alters central vasopressin receptor binding and social interaction in the rat. Tanaka, K., Suzuki, M., Sumiyoshi, T., Murata, M., Tsunoda, M., Kurachi, M. Brain Res. (2003) [Pubmed]
  35. Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Khoshbouei, H., Cecchi, M., Morilak, D.A. Neuropsychopharmacology (2002) [Pubmed]
  36. Quality of life of elderly patients with isolated systolic hypertension: baseline data from the Syst-Eur trial. Syst-Eur Trial Investigators. Fletcher, A.E., Bulpitt, C.J., Tuomilehto, J., Browne, J., Bossini, A., Kawecka-Jaszcz, K., Kivinen, P., O'Brien, E., Staessen, J., Thijs, L., Vänskä, O., Vanhanen, H. J. Hypertens. (1998) [Pubmed]
  37. Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Sams-Dodd, F. Reviews in the neurosciences. (1999) [Pubmed]
  38. Differential effects of intraspecific interactions on the striatal dopamine system in social and non-social voles. Curtis, J.T., Stowe, J.R., Wang, Z. Neuroscience (2003) [Pubmed]
  39. Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen. File, S.E., Mabbutt, P.S., Andrews, N. Psychopharmacology (Berl.) (1991) [Pubmed]
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