Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Gpihbp1 - GPI-anchored HDL-binding protein 1

Mus musculus

Synonyms: 1110002J19Rik, GPI-HBP1, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, Hbp1, High density lipoprotein-binding protein 1

Ioka, R.X. et al., Davies, B.S. et al.

Brandon S. J. Davies, Hironori Waki, Anne P. Beigneux, Emily Farber, Michael M. Weinstein, Damien C. Wilpitz, Li-Jung Tai, Ronald M. Evans, Loren G. Fong, Peter Tontonoz, Stephen G. Young,

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High impact information on Gpihbp1

This newly identified HDL-binding protein designated GPI-anchored HDL-binding protein 1 (GPI-HBP1), was susceptible to phosphatidylinositol-specific phospholipase C treatment and binds HDL with high affinity (calculated K(d) = 2-3 microg/ml) [1].
In situ hybridization revealed the accumulation of GPI-HBP1 transcripts in cardiac muscle cells, hepatic Kupffer cells and sinusoidal endothelium, and bronchial epithelium and alveolar macrophages in the lung [1].

Regulatory relationships of Gpihbp1

Gpihbp1 transcript levels in brown and white adipose tissue were lower in endothelial cell PPARgamma knockout mice than in littermate control mice, suggesting that PPARgamma regulates Gpihbp1 expression in vivo [2].

Other interactions of Gpihbp1

Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1 [1].

References

Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1. Ioka, R.X., Kang, M.J., Kamiyama, S., Kim, D.H., Magoori, K., Kamataki, A., Ito, Y., Takei, Y.A., Sasaki, M., Suzuki, T., Sasano, H., Takahashi, S., Sakai, J., Fujino, T., Yamamoto, T.T. J. Biol. Chem. (2003) [Pubmed]
The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Davies, B.S., Waki, H., Beigneux, A.P., Farber, E., Weinstein, M.M., Wilpitz, D.C., Tai, L.J., Evans, R.M., Fong, L.G., Tontonoz, P., Young, S.G. Mol. Endocrinol. (2008) [Pubmed]

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