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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Macrophages, Alveolar

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Disease relevance of Macrophages, Alveolar


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High impact information on Macrophages, Alveolar


Chemical compound and disease context of Macrophages, Alveolar


Biological context of Macrophages, Alveolar


Anatomical context of Macrophages, Alveolar


Associations of Macrophages, Alveolar with chemical compounds


Gene context of Macrophages, Alveolar

  • Alveolar macrophages derived from asthmatic subjects produce twofold to threefold more GM-CSF than do those from normal control subjects [32].
  • In conclusion, we show that overexpression of HDAC2 in glucocorticoid-insensitive alveolar macrophages from patients with COPD is able to restore glucocorticoid sensitivity [33].
  • Rat alveolar macrophage conditioned media (CM) increased IL-6 secretion by rat ATII cells through the effect of IL-1 and TNF [34].
  • M. tuberculosis and its cell wall components lipoarabinomannan (LAM), lipomannan (LM), and phosphoinositolmannoside (PIM) stimulated IL-8 protein release and mRNA expression in vitro from alveolar macrophages, but deacylated LAM did not [35].
  • We examined the hypothesis that incomplete immunity may result, in part, from RSV-infected alveolar macrophage production of IL-10 which can interfere with the production of immunoregulatory cytokines [36].

Analytical, diagnostic and therapeutic context of Macrophages, Alveolar


  1. Angiotensin convertase activities in human alveolar macrophages: effects of cigarette smoking and sarcoidosis. Hinman, L.M., Stevens, C., Matthay, R.A., Bernard, J., Gee, L. Science (1979) [Pubmed]
  2. Type I interferon induces inhibitory 16-kD CCAAT/ enhancer binding protein (C/EBP)beta, repressing the HIV-1 long terminal repeat in macrophages: pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replication. Honda, Y., Rogers, L., Nakata, K., Zhao, B.Y., Pine, R., Nakai, Y., Kurosu, K., Rom, W.N., Weiden, M. J. Exp. Med. (1998) [Pubmed]
  3. Expression of the Fc-receptor for IgE (Fc epsilon RII, CD23) on alveolar macrophages in extrinsic allergic alveolitis. Pforte, A., Breyer, G., Prinz, J.C., Gais, P., Burger, G., Häussinger, K., Rieber, E.P., Held, E., Ziegler-Heitbrock, H.W. J. Exp. Med. (1990) [Pubmed]
  4. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. Nagaoka, I., Trapnell, B.C., Crystal, R.G. J. Clin. Invest. (1990) [Pubmed]
  5. Vaccination of brushtail possums, Trichosurus vulpecula, with Bacille Calmette-Guerin induces T lymphocytes that reduce Mycobacterium bovis replication in alveolar macrophages via a contact-dependent/nitric oxide-independent mechanism. Denis, M., Wedlock, D.N., Buddle, B.M. Immunol. Cell Biol. (2005) [Pubmed]
  6. The effect of ethanol on adherence and phagocytosis by rabbit alveolar macrophages. Rimland, D., Hand, W.L. J. Lab. Clin. Med. (1980) [Pubmed]
  7. Effects of smoking marijuana, tobacco or cocaine alone or in combination on DNA damage in human alveolar macrophages. Sherman, M.P., Aeberhard, E.E., Wong, V.Z., Simmons, M.S., Roth, M.D., Tashkin, D.P. Life Sci. (1995) [Pubmed]
  8. Induction of transforming growth factor-alpha in activated human alveolar macrophages. Madtes, D.K., Raines, E.W., Sakariassen, K.S., Assoian, R.K., Sporn, M.B., Bell, G.I., Ross, R. Cell (1988) [Pubmed]
  9. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. Martinet, Y., Rom, W.N., Grotendorst, G.R., Martin, G.R., Crystal, R.G. N. Engl. J. Med. (1987) [Pubmed]
  10. Release of prostaglandin D2 into human airways during acute antigen challenge. Murray, J.J., Tonnel, A.B., Brash, A.R., Roberts, L.J., Gosset, P., Workman, R., Capron, A., Oates, J.A. N. Engl. J. Med. (1986) [Pubmed]
  11. Fusion of intracellular membrane pools with cell surfaces of macrophages stimulated by phorbol esters and calcium ionophores. Buys, S.S., Keogh, E.A., Kaplan, J. Cell (1984) [Pubmed]
  12. Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Horwitz, M.A. Cell (1984) [Pubmed]
  13. Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation. Koziel, H., Eichbaum, Q., Kruskal, B.A., Pinkston, P., Rogers, R.A., Armstrong, M.Y., Richards, F.F., Rose, R.M., Ezekowitz, R.A. J. Clin. Invest. (1998) [Pubmed]
  14. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. Adams, J.S., Sharma, O.P., Gacad, M.A., Singer, F.R. J. Clin. Invest. (1983) [Pubmed]
  15. Tissue factor activity. A marker of alveolar macrophage maturation in rabbits. Effects of granulomatous pneumonitis. Rothberger, H., McGee, M.P., Lee, T.K. J. Clin. Invest. (1984) [Pubmed]
  16. Stimulation of alveolar macrophages in asthmatic patients after local provocation test. Tonnel, A.B., Joseph, M., Gosset, P., Fournier, E., Capron, A. Lancet (1983) [Pubmed]
  17. Reduced tissue macrophage population in the lung by anticancer agent cyclophosphamide: restoration by local granulocyte macrophage-colony-stimulating factor gene transfer. Santosuosso, M., Divangahi, M., Zganiacz, A., Xing, Z. Blood (2002) [Pubmed]
  18. Real-time quantitative RT-PCR after laser-assisted cell picking. Fink, L., Seeger, W., Ermert, L., Hänze, J., Stahl, U., Grimminger, F., Kummer, W., Bohle, R.M. Nat. Med. (1998) [Pubmed]
  19. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Shibata, Y., Berclaz, P.Y., Chroneos, Z.C., Yoshida, M., Whitsett, J.A., Trapnell, B.C. Immunity (2001) [Pubmed]
  20. Origin and kinetics of pulmonary macrophages during an inflammatory reaction induced by intravenous administration of heat-killed bacillus Calmette-Guérin. Blussé van Oud Alblas, A., van der Linden-Schrever, B., van Furth, R. J. Exp. Med. (1981) [Pubmed]
  21. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. Chelen, C.J., Fang, Y., Freeman, G.J., Secrist, H., Marshall, J.D., Hwang, P.T., Frankel, L.R., DeKruyff, R.H., Umetsu, D.T. J. Clin. Invest. (1995) [Pubmed]
  22. Down-regulation by interleukin 4 of activation of human alveolar macrophages to the tumoricidal state. Nishioka, Y., Sone, S., Orino, E., Nii, A., Ogura, T. Cancer Res. (1991) [Pubmed]
  23. Pulmonary oxygen toxicity. Early reversible changes in human alveolar structures induced by hyperoxia. Davis, W.B., Rennard, S.I., Bitterman, P.B., Crystal, R.G. N. Engl. J. Med. (1983) [Pubmed]
  24. Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. Huang, W.W., Garcia-Zepeda, E.A., Sauty, A., Oettgen, H.C., Rothenberg, M.E., Luster, A.D. J. Exp. Med. (1998) [Pubmed]
  25. Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung. Davis, D.W., Weidner, D.A., Holian, A., McConkey, D.J. J. Exp. Med. (2000) [Pubmed]
  26. Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. Welgus, H.G., Campbell, E.J., Cury, J.D., Eisen, A.Z., Senior, R.M., Wilhelm, S.M., Goldberg, G.I. J. Clin. Invest. (1990) [Pubmed]
  27. Analysis of the effect of amines on inhibition of receptor-mediated and fluid-phase pinocytosis in rabbit alveolar macrophages. Kaplan, J., Keogh, E.A. Cell (1981) [Pubmed]
  28. Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor. Ezekowitz, R.A., Williams, D.J., Koziel, H., Armstrong, M.Y., Warner, A., Richards, F.F., Rose, R.M. Nature (1991) [Pubmed]
  29. IgE-dependent release of leukotriene C4 from alveolar macrophages. Rankin, J.A., Hitchcock, M., Merrill, W., Bach, M.K., Brashler, J.R., Askenase, P.W. Nature (1982) [Pubmed]
  30. A newly defined property of somatotropin: priming of macrophages for production of superoxide anion. Edwards, C.K., Ghiasuddin, S.M., Schepper, J.M., Yunger, L.M., Kelley, K.W. Science (1988) [Pubmed]
  31. Angiotensin converting enzyme: induction by steroids in rabbit alveolar macrophages in culture. Friedland, J., Setton, C., Silverstein, E. Science (1977) [Pubmed]
  32. The pathobiology of bronchial asthma. Arm, J.P., Lee, T.H. Adv. Immunol. (1992) [Pubmed]
  33. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P.J., Adcock, I.M. J. Exp. Med. (2006) [Pubmed]
  34. Alveolar type II epithelial cells produce interleukin-6 in vitro and in vivo. Regulation by alveolar macrophage secretory products. Crestani, B., Cornillet, P., Dehoux, M., Rolland, C., Guenounou, M., Aubier, M. J. Clin. Invest. (1994) [Pubmed]
  35. Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components. Zhang, Y., Broser, M., Cohen, H., Bodkin, M., Law, K., Reibman, J., Rom, W.N. J. Clin. Invest. (1995) [Pubmed]
  36. Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. Suppression of early cytokine production and implications for incomplete immunity. Panuska, J.R., Merolla, R., Rebert, N.A., Hoffmann, S.P., Tsivitse, P., Cirino, N.M., Silverman, R.H., Rankin, J.A. J. Clin. Invest. (1995) [Pubmed]
  37. Synthesis of leukotriene C and other arachidonic acid metabolites by mouse pulmonary macrophages. Rouzer, C.A., Scott, W.A., Hamill, A.L., Cohn, Z.A. J. Exp. Med. (1982) [Pubmed]
  38. Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage. Martin, T.R., Raugi, G., Merritt, T.L., Henderson, W.R. J. Clin. Invest. (1987) [Pubmed]
  39. Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. Khalil, N., Whitman, C., Zuo, L., Danielpour, D., Greenberg, A. J. Clin. Invest. (1993) [Pubmed]
  40. Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages. Reilly, J.J., Chen, P., Sailor, L.Z., Mason, R.W., Chapman, H.A. J. Clin. Invest. (1990) [Pubmed]
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