The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TBCD  -  tubulin folding cofactor D

Homo sapiens

Synonyms: Beta-tubulin cofactor D, KIAA0988, PP1096, SSD-1, SSD1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TBCD


Biological context of TBCD

  • Single copy expression of SSD1/SRK1 was sufficient to suppress the thermosensitive phenotype, and high copy expression partially suppressed the splicing and U4/U6.U5 tri-snRNP assembly pheno-types [3].

Anatomical context of TBCD

  • Because tfcD was shown to be a microtubule-destabilizing protein, our data suggest a shear stress-dependent regulation of the microtubular dynamics in human endothelial cells [2].

Analytical, diagnostic and therapeutic context of TBCD

  • According to Northern blot analysis, corresponding SSD-1 cDNA clones revealed a similar, time-dependent downregulation after 24 hours of arterial shear stress compared with venous shear stress or static controls [2].


  1. Tubulin folding cofactor D is a microtubule destabilizing protein. Martín, L., Fanarraga, M.L., Aloria, K., Zabala, J.C. FEBS Lett. (2000) [Pubmed]
  2. Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene. Schubert, A., Cattaruzza, M., Hecker, M., Darmer, D., Holtz, J., Morawietz, H. Circ. Res. (2000) [Pubmed]
  3. A conditional U5 snRNA mutation affecting pre-mRNA splicing and nuclear pre-mRNA retention identifies SSD1/SRK1 as a general splicing mutant suppressor. Luukkonen, B.G., Séraphin, B. Nucleic Acids Res. (1999) [Pubmed]
WikiGenes - Universities