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Gene Review:

Esam - endothelial cell-specific adhesion molecule

Mus musculus

Synonyms: 2310008D05Rik, Endothelial cell-selective adhesion molecule, Esam1, W117m

Kawachi, S. et al., Liao, F. et al., Owens, R. et al.

Liao, Doody, Overholser, Finnerty, Bassi, Wu, Dejana, Kussie, Bohlen, Hicklin,

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Disease relevance of Esam1

Our data confirm that reconstitution of SCID mice with CD45RB(high) but not CD45RB(low) T-cells induces chronic colitis and demonstrate that this chronic colitis is associated with enhanced expression of an endothelial cell-specific adhesion molecule [1].

High impact information on Esam1

Vascular endothelial-cadherin (VE-cadherin) is an endothelial cell-specific adhesion molecule that is localized exclusively at cell-cell contacts referred to as adherens junctions [2].
BACKGROUND: E-selectin is an endothelial cell specific adhesion molecule that is believed to play an important role in the early stages of leukocyte extravasation [3].

References

E-Selectin expression in a murine model of chronic colitis. Kawachi, S., Morise, Z., Conner, E., Laroux, F.S., Gray, L., Fuseler, J., Grisham, M.B. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability. Liao, F., Doody, J.F., Overholser, J., Finnerty, B., Bassi, R., Wu, Y., Dejana, E., Kussie, P., Bohlen, P., Hicklin, D.J. Cancer Res. (2002) [Pubmed]
The in vivo and in vitro characterisation of an engineered human antibody to E-selectin. Owens, R., Ball, E., Ganesh, R., Nesbitt, A., Brown, D., Gofton, C., Stephens, S., Chaplin, L., Christofidou-Solomidou, M., Blake, S., Howat, D., Buurman, W.A., Albelda, S., Robinson, M.K. Immunotechnology (1997) [Pubmed]

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ESAM	Bos taurus
ESAM	Canis lupus familiaris
esama	Danio rerio
esamb	Danio rerio
ESAM	Gallus gallus
ESAM	Homo sapiens
ESAM	Macaca mulatta
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Esam	Rattus norvegicus
esam	Xenopus (Silurana) tropicalis

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