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Gene Review

ESAM  -  endothelial cell adhesion molecule

Homo sapiens

Synonyms: Endothelial cell-selective adhesion molecule, UNQ220/PRO246, W117m
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Disease relevance of ESAM


Psychiatry related information on ESAM


High impact information on ESAM


Chemical compound and disease context of ESAM


Biological context of ESAM


Anatomical context of ESAM


Associations of ESAM with chemical compounds


Other interactions of ESAM


Analytical, diagnostic and therapeutic context of ESAM


  1. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis. Suzu, S., Hayashi, Y., Harumi, T., Nomaguchi, K., Yamada, M., Hayasawa, H., Motoyoshi, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. Saeed, R.W., Varma, S., Peng-Nemeroff, T., Sherry, B., Balakhaneh, D., Huston, J., Tracey, K.J., Al-Abed, Y., Metz, C.N. J. Exp. Med. (2005) [Pubmed]
  3. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Horak, E.R., Leek, R., Klenk, N., LeJeune, S., Smith, K., Stuart, N., Greenall, M., Stepniewska, K., Harris, A.L. Lancet (1992) [Pubmed]
  4. Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone. Ozawa, K., Tsukamoto, Y., Hori, O., Kitao, Y., Yanagi, H., Stern, D.M., Ogawa, S. Cancer Res. (2001) [Pubmed]
  5. Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa. Coll-Vinent, B., Cebrián, M., Cid, M.C., Font, C., Esparza, J., Juan, M., Yagüe, J., Urbano-Márquez, A., Grau, J.M. Arthritis Rheum. (1998) [Pubmed]
  6. Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells. Skilton, M.R., Nakhla, S., Sieveking, D.P., Caterson, I.D., Celermajer, D.S. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
  7. ELAM-1 is an adhesion molecule for skin-homing T cells. Picker, L.J., Kishimoto, T.K., Smith, C.W., Warnock, R.A., Butcher, E.C. Nature (1991) [Pubmed]
  8. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Gavard, J., Gutkind, J.S. Nat. Cell Biol. (2006) [Pubmed]
  9. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression. Caulin-Glaser, T., Watson, C.A., Pardi, R., Bender, J.R. J. Clin. Invest. (1996) [Pubmed]
  10. Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell. Zhao, T., Newman, P.J. J. Cell Biol. (2001) [Pubmed]
  11. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. MacMaster, J.F., Dambach, D.M., Lee, D.B., Berry, K.K., Qiu, Y., Zusi, F.C., Burke, J.R. Inflamm. Res. (2003) [Pubmed]
  12. Characterization of a human homologue of the murine peripheral lymph node homing receptor. Bowen, B.R., Nguyen, T., Lasky, L.A. J. Cell Biol. (1989) [Pubmed]
  13. RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells. Pluvinet, R., Pétriz, J., Torras, J., Herrero-Fresneda, I., Cruzado, J.M., Grinyó, J.M., Aran, J.M. Blood (2004) [Pubmed]
  14. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. Pierce, J.W., Schoenleber, R., Jesmok, G., Best, J., Moore, S.A., Collins, T., Gerritsen, M.E. J. Biol. Chem. (1997) [Pubmed]
  15. Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18). Berman, M.E., Muller, W.A. J. Immunol. (1995) [Pubmed]
  16. Functional implication of the hydrolysis of platelet endothelial cell adhesion molecule 1 (CD31) by gingipains of Porphyromonas gingivalis for the pathology of periodontal disease. Yun, P.L., Decarlo, A.A., Chapple, C.C., Hunter, N. Infect. Immun. (2005) [Pubmed]
  17. Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. Hirata Ki, n.u.l.l., Ishida, T., Penta, K., Rezaee, M., Yang, E., Wohlgemuth, J., Quertermous, T. J. Biol. Chem. (2001) [Pubmed]
  18. Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Wegmann, F., Ebnet, K., Du Pasquier, L., Vestweber, D., Butz, S. Exp. Cell Res. (2004) [Pubmed]
  19. Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Walz, G., Aruffo, A., Kolanus, W., Bevilacqua, M., Seed, B. Science (1990) [Pubmed]
  20. Monoclonal antibodies to human lymphocyte homing receptors define a novel class of adhesion molecules on diverse cell types. Picker, L.J., Nakache, M., Butcher, E.C. J. Cell Biol. (1989) [Pubmed]
  21. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. Kwon, H.M., Choi, Y.J., Choi, J.S., Kang, S.W., Bae, J.Y., Kang, I.J., Jun, J.G., Lee, S.S., Lim, S.S., Kang, Y.H. Exp. Biol. Med. (Maywood) (2007) [Pubmed]
  22. Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro. Saeed, R.W., Varma, S., Peng, T., Tracey, K.J., Sherry, B., Metz, C.N. J. Immunol. (2004) [Pubmed]
  23. Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells. Leavesley, D.I., Oliver, J.M., Swart, B.W., Berndt, M.C., Haylock, D.N., Simmons, P.J. J. Immunol. (1994) [Pubmed]
  24. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. Sadeghi, M.M., Collinge, M., Pardi, R., Bender, J.R. J. Immunol. (2000) [Pubmed]
  25. Modulation by high glucose of adhesion molecule expression in cultured endothelial cells. Baumgartner-Parzer, S.M., Wagner, L., Pettermann, M., Gessl, A., Waldhäusl, W. Diabetologia (1995) [Pubmed]
  26. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  27. Results of the European Survey on Anaemia Management 2003 (ESAM 2003): current status of anaemia management in dialysis patients, factors affecting epoetin dosage and changes in anaemia management over the last 5 years. Jacobs, C., Frei, D., Perkins, A.C. Nephrol. Dial. Transplant. (2005) [Pubmed]
  28. The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo. Stanford, M.M., Issekutz, T.B. J. Leukoc. Biol. (2003) [Pubmed]
  29. Novel cytokine-independent induction of endothelial adhesion molecules regulated by platelet/endothelial cell adhesion molecule (CD31). Litwin, M., Clark, K., Noack, L., Furze, J., Berndt, M., Albelda, S., Vadas, M., Gamble, J. J. Cell Biol. (1997) [Pubmed]
  30. The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets. Stangl, V., Lorenz, M., Ludwig, A., Grimbo, N., Guether, C., Sanad, W., Ziemer, S., Martus, P., Baumann, G., Stangl, K. J. Nutr. (2005) [Pubmed]
  31. Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1. Xie, Y., Muller, W.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  32. Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts. Briscoe, D.M., Yeung, A.C., Schoen, F.J., Allred, E.N., Stavrakis, G., Ganz, P., Cotran, R.S., Pober, J.S., Schoen, E.L. Transplantation (1995) [Pubmed]
  33. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31. Pumphrey, N.J., Taylor, V., Freeman, S., Douglas, M.R., Bradfield, P.F., Young, S.P., Lord, J.M., Wakelam, M.J., Bird, I.N., Salmon, M., Buckley, C.D. FEBS Lett. (1999) [Pubmed]
  34. Adhesion of nonmetastatic and highly metastatic breast cancer cells to endothelial cells exposed to shear stress. Moss, M.S., Sisken, B., Zimmer, S., Anderson, K.W. Biorheology. (1999) [Pubmed]
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