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Gene Review

Sele  -  selectin, endothelial cell

Mus musculus

Synonyms: CD62 antigen-like family member E, CD62E, E-selectin, ELAM-1, Elam, ...
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Disease relevance of Sele


High impact information on Sele


Chemical compound and disease context of Sele


Biological context of Sele


Anatomical context of Sele


Associations of Sele with chemical compounds


Physical interactions of Sele

  • These studies confirmed that core-2 O-glycans attached to Thr-57 play a critical role in supporting L- and P-selectin-dependent rolling and revealed that additional binding sites support >75% of E-selectin-mediated rolling [23].
  • The replacement of Trp 5 with Phe resulted in a change of peptide's secondary structure and increased binding with MAb and E-selectin, suggesting improved carbohydrate mimicry [24].
  • Fluid-phase E-selectin bound to approximately 70% fewer sites on PSGL-1-/- than PSGL-1+/+ neutrophils [25].
  • The E-selectin-ligand-1 (ESL-1) is a high affinity glycoprotein ligand which participates in the binding of mouse myeloid cells to E-selectin [26].
  • We found that a large fraction of CD4+ T cells from inflamed colonic LP and from non-inflamed PC, mLN and S expressed high levels of P- and E-selectin-binding epitopes (P-Lhi) in transplanted scid mice, but not in congenic, immunocompetent control mice [27].

Regulatory relationships of Sele


Other interactions of Sele

  • We have quantitated the effect of deficiency for intercellular adhesion molecule (ICAM)-1, P-selectin, or E-selectin on atherosclerotic lesion formation at 20 wk of age in apolipoprotein (apo) E(-/-) (deficient) mice fed a normal chow diet [32].
  • Rolling did not involve L-selectin, but was partially reduced in wild-type mice treated with antibodies to P- or E-selectin and in mice that were deficient in these two selectins [33].
  • In vitro studies demonstrated that binding of recombinant mouse E-selectin chimera to PSGL-1(-/-) neutrophils was dramatically decreased in mice treated systemically but not locally with TNF-alpha [1].
  • However, controversy exists regarding the importance of PSGL-1-dependent and -independent E-selectin rolling [1].
  • Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation [20].

Analytical, diagnostic and therapeutic context of Sele


  1. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Zanardo, R.C., Bonder, C.S., Hwang, J.M., Andonegui, G., Liu, L., Vestweber, D., Zbytnuik, L., Kubes, P. Blood (2004) [Pubmed]
  2. E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. Horikawa, M., Fujimoto, M., Hasegawa, M., Matsushita, T., Hamaguchi, Y., Kawasuji, A., Matsushita, Y., Fujita, T., Ogawa, F., Takehara, K., Steeber, D.A., Sato, S. Am. J. Pathol. (2006) [Pubmed]
  3. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. Yanaba, K., Kaburagi, Y., Takehara, K., Steeber, D.A., Tedder, T.F., Sato, S. Am. J. Pathol. (2003) [Pubmed]
  4. E-selectin early overexpression induced by allogeneic activation in isolated mouse lung. Joucher, F., Mazmanian, G.M., German-Fattal, M. Transplantation (2004) [Pubmed]
  5. The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. Hicks, A.E., Abbitt, K.B., Dodd, P., Ridger, V.C., Hellewell, P.G., Norman, K.E. J. Leukoc. Biol. (2005) [Pubmed]
  6. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Austrup, F., Vestweber, D., Borges, E., Löhning, M., Bräuer, R., Herz, U., Renz, H., Hallmann, R., Scheffold, A., Radbruch, A., Hamann, A. Nature (1997) [Pubmed]
  7. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Reimold, A.M., Grusby, M.J., Kosaras, B., Fries, J.W., Mori, R., Maniwa, S., Clauss, I.M., Collins, T., Sidman, R.L., Glimcher, M.J., Glimcher, L.H. Nature (1996) [Pubmed]
  8. The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Steegmaier, M., Levinovitz, A., Isenmann, S., Borges, E., Lenter, M., Kocher, H.P., Kleuser, B., Vestweber, D. Nature (1995) [Pubmed]
  9. Murine hepatic microvascular adhesion molecule expression is inducible and has a zonal distribution. Wang, H.H., Nance, D.M., Orr, F.W. Clin. Exp. Metastasis (1999) [Pubmed]
  10. CD44 is a physiological E-selectin ligand on neutrophils. Katayama, Y., Hidalgo, A., Chang, J., Peired, A., Frenette, P.S. J. Exp. Med. (2005) [Pubmed]
  11. Regulation of intestinal nuclear factor-kappaB activity and E-selectin expression during sepsis: a role for peroxynitrite. Lush, C.W., Cepinskas, G., Kvietys, P.R. Gastroenterology (2003) [Pubmed]
  12. Divergent inducible expression of P-selectin and E-selectin in mice and primates. Yao, L., Setiadi, H., Xia, L., Laszik, Z., Taylor, F.B., McEver, R.P. Blood (1999) [Pubmed]
  13. Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. Winkler, I.G., Snapp, K.R., Simmons, P.J., Lévesque, J.P. Blood (2004) [Pubmed]
  14. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Underhill, G.H., Minges Wols, H.A., Fornek, J.L., Witte, P.L., Kansas, G.S., Minges-Wols, H.A. Blood (2002) [Pubmed]
  15. Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature. Norman, M.U., Van De Velde, N.C., Timoshanko, J.R., Issekutz, A., Hickey, M.J. Am. J. Pathol. (2003) [Pubmed]
  16. Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin. Jutila, M.A., Watts, G., Walcheck, B., Kansas, G.S. J. Exp. Med. (1992) [Pubmed]
  17. L-selectin from human, but not from mouse neutrophils binds directly to E-selectin. Zöllner, O., Lenter, M.C., Blanks, J.E., Borges, E., Steegmaier, M., Zerwes, H.G., Vestweber, D. J. Cell Biol. (1997) [Pubmed]
  18. Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Pati, S., Pelser, C.B., Dufraine, J., Bryant, J.L., Reitz, M.S., Weichold, F.F. Blood (2002) [Pubmed]
  19. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Katayama, Y., Hidalgo, A., Furie, B.C., Vestweber, D., Furie, B., Frenette, P.S. Blood (2003) [Pubmed]
  20. Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation. Fries, J.W., Williams, A.J., Atkins, R.C., Newman, W., Lipscomb, M.F., Collins, T. Am. J. Pathol. (1993) [Pubmed]
  21. L- and E-selectin can recognize the same naturally occurring ligands on high endothelial venules. Mebius, R.E., Watson, S.R. J. Immunol. (1993) [Pubmed]
  22. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Labow, M.A., Norton, C.R., Rumberger, J.M., Lombard-Gillooly, K.M., Shuster, D.J., Hubbard, J., Bertko, R., Knaack, P.A., Terry, R.W., Harbison, M.L. Immunity (1994) [Pubmed]
  23. Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. Martinez, M., Joffraud, M., Giraud, S., Baïsse, B., Bernimoulin, M.P., Schapira, M., Spertini, O. J. Biol. Chem. (2005) [Pubmed]
  24. Role of SA-Le(a) and E-selectin in metastasis assessed with peptide antagonist. O, I., Otvos, L., Kieber-Emmons, T., Blaszczyk-Thurin, M. Peptides (2002) [Pubmed]
  25. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. Xia, L., Sperandio, M., Yago, T., McDaniel, J.M., Cummings, R.D., Pearson-White, S., Ley, K., McEver, R.P. J. Clin. Invest. (2002) [Pubmed]
  26. The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface. Steegmaier, M., Borges, E., Berger, J., Schwarz, H., Vestweber, D. J. Cell. Sci. (1997) [Pubmed]
  27. Expression of selectin-binding epitopes and cytokines by CD4+ T cells repopulating scid mice with colitis. Thoma, S., Bonhagen, K., Vestweber, D., Hamann, A., Reimann, J. Eur. J. Immunol. (1998) [Pubmed]
  28. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo. Norman, K.E., Katopodis, A.G., Thoma, G., Kolbinger, F., Hicks, A.E., Cotter, M.J., Pockley, A.G., Hellewell, P.G. Blood (2000) [Pubmed]
  29. Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin. Walter, U.M., Ayer, L.M., Manning, A.M., Frenette, P.S., Wagner, D.D., Hynes, R.O., Wolitzky, B.A., Issekutz, A.C. Hybridoma (1997) [Pubmed]
  30. E- and P-selectins are essential for the development of cockroach allergen-induced airway responses. Lukacs, N.W., John, A., Berlin, A., Bullard, D.C., Knibbs, R., Stoolman, L.M. J. Immunol. (2002) [Pubmed]
  31. Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. Reinhardt, R.L., Bullard, D.C., Weaver, C.T., Jenkins, M.K. J. Exp. Med. (2003) [Pubmed]
  32. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. Collins, R.G., Velji, R., Guevara, N.V., Hicks, M.J., Chan, L., Beaudet, A.L. J. Exp. Med. (2000) [Pubmed]
  33. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Mazo, I.B., Gutierrez-Ramos, J.C., Frenette, P.S., Hynes, R.O., Wagner, D.D., von Andrian, U.H. J. Exp. Med. (1998) [Pubmed]
  34. TNF-alpha contributes to the development of allergic rhinitis in mice. Iwasaki, M., Saito, K., Takemura, M., Sekikawa, K., Fujii, H., Yamada, Y., Wada, H., Mizuta, K., Seishima, M., Ito, Y. J. Allergy Clin. Immunol. (2003) [Pubmed]
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