Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Cic - capicua homolog (Drosophila)

Mus musculus

Synonyms: 1200010B10Rik, Kiaa0306, Protein capicua homolog, mKIAA0306

Lee, C.J. et al., Lee, C.J. et al.

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Disease relevance of Cic

Cic has been implicated as a mediator of ErbB signaling and this pathway has been associated with a poor prognosis for medulloblastomas [1].

High impact information on Cic

We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes [2].
Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS [2].

Analytical, diagnostic and therapeutic context of Cic

In postnatally developing cerebellum, in silico analysis and in situ hybridization both indicated a strong correlation between Cic expression and the maturation profile of cerebellar granule cell precursors [1].

References

CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. Lee, C.J., Chan, W.I., Scotting, P.J. J. Neurooncol. (2005) [Pubmed]
CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. Lee, C.J., Chan, W.I., Cheung, M., Cheng, Y.C., Appleby, V.J., Orme, A.T., Scotting, P.J. Brain Res. Mol. Brain Res. (2002) [Pubmed]

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