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Gene Review

Cic  -  capicua homolog (Drosophila)

Mus musculus

Synonyms: 1200010B10Rik, Kiaa0306, Protein capicua homolog, mKIAA0306
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Disease relevance of Cic

  • Cic has been implicated as a mediator of ErbB signaling and this pathway has been associated with a poor prognosis for medulloblastomas [1].

High impact information on Cic

  • We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes [2].
  • Expression of the Cic gene is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS [2].

Analytical, diagnostic and therapeutic context of Cic

  • In postnatally developing cerebellum, in silico analysis and in situ hybridization both indicated a strong correlation between Cic expression and the maturation profile of cerebellar granule cell precursors [1].


  1. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. Lee, C.J., Chan, W.I., Scotting, P.J. J. Neurooncol. (2005) [Pubmed]
  2. CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. Lee, C.J., Chan, W.I., Cheung, M., Cheng, Y.C., Appleby, V.J., Orme, A.T., Scotting, P.J. Brain Res. Mol. Brain Res. (2002) [Pubmed]
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