Disease relevance of CIC

• In the present study the expression of human CIC in medulloblastoma was analyzed [1].
• One of the most common forms of carcinoma in women, cervical invasive squamous cell carcinoma (CIC), often coexists with multiple lesions of cervical intraepithelial neoplasia (CIN) [2].
• Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation [3].
• Since there was no significant increase of IgE-CIC 10 min after bronchial allergen challenge nor at the moment that symptoms such as urticaria, bronchial obstruction, or rhinorrhea appeared during rush hyposensitization in asthmatic patients, we think that CIC are not involved in classic type I allergic reactions [4].
• CONCLUSION: CIC was associated with moderate toxicity and only modest antitumor activity [5].

Psychiatry related information on CIC

• Changing views about personality disorders: Comment about the prospective studies CIC, CLPS, and MSAD [6].

High impact information on CIC

• In contrast to most known ion channels, which have single pores, a chloride channel belonging to the CIC family (Torpedo CIC-0) has functional features that suggest that it has a unique 'double-barrelled' architecture in which each of two subunits forms an independent pore [7].
• Although the CIC channels expressed in Xenopus oocytes have been characterized, their channel properties are still poorly understood [8].
• Indeed, CIC-DUX4 directly binds the ERM promoter by recognizing a novel target sequence and significantly up-regulates its expression [3].
• Sequence analysis of 780 bp of ORF from the clones suggests that the identified gene, termed hCIC-K2, encodes a new member of the CIC family of voltage-gated chloride channels [9].
• Using a specific antibody raised against a 15-amino acid peptide from the CIC sequence, we concluded that CIC and P25 are identical entities, and hence that P25 belongs to the MIP family [10].

Chemical compound and disease context of CIC

• CBS domains in CIC chloride channels implicated in myotonia and nephrolithiasis (kidney stones) [11].
• BACKGROUND: We conducted a dose escalation study combining cisplatin, irinotecan, and capecitabine (CIC), aiming to establish the maximum tolerated doses (MTD), side effect profile, and dose-limiting toxicity (DLT) of this novel regimen [5].
• Reported here is a pilot study using chronomodulated infusional 5-fluorouracil (5-FU) chemoradiation (CIC) for pancreatic cancer, a treatment designed to reduce normal tissue toxicity and maintain efficacy, with specific evaluation of acute and late morbidity, patterns of disease progression, and survival [12].
• The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice [13].
• In the present study we attempted to clarify whether CIC cholesterol level correlates with the severity of coronary atherosclerosis [14].

Biological context of CIC

• Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific [15].
• A new cold-regulated (COR) gene, msa CIC, was isolated by differential screening of a cDNA library from cold-acclimated crowns of alfalfa (Medicago sativa L. cv. Apica) [16].
• The DNA sequence analysis of a full-length cDNA clone revealed that msa CIC encodes for a putative protein (MSACIC) of 166 amino acids with distinct proline-rich and hydrophobic domains [16].
• The concentration of CIC and the light dose that correspond to ca 50% level of phototoxicity induce predominantly an apoptotic-type of cell death, whereas the conditions providing 100% level of phototoxicity induced necrosis [17].
• No significant relationship among erythrocyte CR1 molecules, erythrocyte surface-associated immunoglobulins, CIC, and HLA phenotype was observed in any patient group [18].

Anatomical context of CIC

• Thus, removal of the immunosuppressive agents, ie, the CIC, may lead to a modulation of the immunosuppression and a liberation of the immune system to perform an antitumor effect [19].
• These findings suggest that the lesions observed in late-onset rubella syndrome are partly due to CIC, and that suscepibility to infection can be related to a peripheral T and B lymphocyte disequilibrium [20].
• In membranous nephropathy erythrocyte CR1 molecules were quantitatively similar to control data and no increase in CIC was observed [18].
• The intracellular accumulation of CIC occurs in cytoplasm in a monomeric form bound to cellular membranes [17].
• Elevated levels of IgA containing circulating immune complexes (IgA-CIC) and IgG containing (IgG-) CIC were detected in patients with obstructive jaundice due to biliary tract stones and/or tumour of biliary tract or pancreas [21].

Associations of CIC with chemical compounds

• Although PEG precipitates were enriched for high molecular weight IgA and IgG (presumably bound within CIC), significant amounts of IgM, unbound IgG and C3 were also present [22].
• Compounds of more recent research are MERCK 3535 (aminopropionic acid ethylester), p-menthane-3,8 diol, CIC 4 (a lacton) and the piperidine derivatives AI3-37220 and Bayrepel (Icaridin) [23].
• In addition, the CIC cholesterol level diagnoses extracoronary atherosclerosis with high accuracy [14].
• Even though vitamin A supplementation in malnourished children did not significantly alter the duration of diarrhea, a beneficial effect was observed in children who had CIC state 3 and above in association with malnutrition (p = 0.025) [24].
• The determination of CIC is carried out by means of precipitation with 3.5% PEG and a posterior determination of C4 of the precipitates as well as optical density [25].

Other interactions of CIC

• This study clarifies the function of CIC and its role in tumorigenesis, as well as the importance of the PEA3 subclass of ETS family proteins in the development of EFTs arising through mechanisms different from those involving EWS-ETS chimeras [3].
• In a parallel study increased CIC and anti-IgG Ab levels were found in most of the 81 patients with seropositive or seronegative rheumatoid arthritis [26].
• The levels of L-CR1 transcription correlated negatively with the levels of CIC and anti dsDNA antibodies and positively with serum C3 levels [27].
• The influence of therapeutic regimens on elevated CIC level in the CSF was insignificant [28].
• Obstructive complications were defined as increased PVR (greater than 100 cc), or the need for CIC, prolonged Foley catheter drainage or urethrolysis [29].

Analytical, diagnostic and therapeutic context of CIC

• RT-PCR and in situ hybridization verified the expression of CIC in tumor cells, although the level of expression varied between different medulloblastoma subtypes [1].
• CIC have played a major role in cancer-associated immunosuppression [19].
• In these patients, there was a good correlation between the level of IgM-RF and the amount of IgE detected in the CIC by the RIA method (r = 0.87) whereas the RF-interference free ELISA method showed no correlation between these two parameters (r = 0.06) [30].
• Analysis of sera by HPLC revealed that both monomeric and higher molecular forms of IgA antibodies were present, the latter being coincident with the peak of IgA CIC [31].
• The incidence of Epstein-Barr virus (EBV) viraemia and lymphoproliferative disease (LPD) was studied in a consecutive cohort of 128 paediatric patients undergoing stem cell transplantation (SCT) with reduced-intensity conditioning (RIC; n = 65) or conventional-intensity conditioning (CIC; n = 68) [32].

References