Gene Review:
Tekt4 - tektin 4
Mus musculus
Synonyms:
1700010L19Rik, Tektin-4, Testicular microtubules-related protein 4
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High impact information on Tekt4
- Tekt4-null sperm exhibit drastically reduced forward progressive velocity and uncoordinated waveform propagation along the flagellum [1].
- However, the ineffective flagellar strokes lead to approximately 10-fold higher consumption of intracellular ATP in Tekt4-null sperm as compared to wild-type, and null spermatozoa rapidly lose progressive motility when incubated for > or = 1.5 h [1].
- Mouse Tekt4 is a germ cell-enriched gene, most abundantly expressed in haploid round spermatids in the testis, and the protein is localized to the sperm flagella [1].
Analytical, diagnostic and therapeutic context of Tekt4
- In Tekt4-null sperm, flagellar ultrastructure is grossly unaltered as revealed by transmission electron microscopy [1].
References
- Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. Roy, A., Lin, Y.N., Agno, J.E., DeMayo, F.J., Matzuk, M.M. FASEB J. (2007) [Pubmed]
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