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Gene Review:

TRG-GCC2-4 - transfer RNA-Gly (GCC) 2-4

Homo sapiens

Synonyms: TRG2, TRNAG2

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Disease relevance of TRNAG2

A favorable outcome for OS, DFS, and local control was observed in patients with TRG2-4 (i.e., responders) compared with patients with TRG5 (i.e., nonresponders), but also in patients with low residual tumor cell density (TRG2, 3, and 4) [1].

High impact information on TRNAG2

The simultaneous results on the TRG2@ locus molecular organization in sheep and on the phylogenetic analysis of cattle and sheep V expressed sequences indicate that at least six TRG clusters distributed in the two loci are present in these ruminant animals [2].
These data suggest that productive rearrangements on TRG1 leading to the production of a surface-expressed gamma chain occur before rearrangements involving the TRG2 region [3].

Biological context of TRNAG2

Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus [2].
Only TRG1@ is included within a region of homology with human TRG locus on chromosome 7, thus TRG2@ locus appears to be peculiar to ruminants [2].

Anatomical context of TRNAG2

The availability of genomic clones representative of the T cell receptor gamma (TRG1@ and TRG2@) ovine loci enabled us to compare the germline genomic organization and nucleotide diversity of joining (J) segments and reconstruct their evolutionary history by phylogenetic analysis of cattle, sheep and human expressed sequences [4].

Other interactions of TRNAG2

TRG1 was recorded in 27% of the patients, and a further 27% were classified as TRG2 [5].

References

Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Bouzourene, H., Bosman, F.T., Seelentag, W., Matter, M., Coucke, P. Cancer (2002) [Pubmed]
Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus. Miccoli, M.C., Antonacci, R., Vaccarelli, G., Lanave, C., Massari, S., Cribiu, E.P., Ciccarese, S. J. Mol. Evol. (2003) [Pubmed]
Further evidence for a sequentially ordered activation of T cell rearranging gamma genes during T lymphocyte differentiation. Tribel, F., Lefranc, M.P., Hercend, T. Eur. J. Immunol. (1988) [Pubmed]
Comparative analyses of sheep and human TRG joining regions: evolution of J genes in Bovidae is driven by sequence conservation in their promoters for germline transcription. Miccoli, M.C., Vaccarelli, G., Lanave, C., Cribiu, E.P., Ciccarese, S. Gene (2005) [Pubmed]
Preoperative chemoradiation of locally advanced T3 rectal cancer combined with an endorectal boost. Jakobsen, A., Mortensen, J.P., Bisgaard, C., Lindebjerg, J., Hansen, J.W., Rafaelsen, S.R. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]

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