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Gene Review

Ripk4  -  receptor-interacting serine-threonine...

Mus musculus

Synonyms: 2310069J12Rik, AI552420, ANKK2, Ankrd3, Ankyrin repeat domain-containing protein 3, ...
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High impact information on Ripk4

  • Protein kinase C-associated kinase (PKK)/receptor interacting protein 4 (RIP4) is a protein kinase C (PKC) beta-associated kinase that links PKC to NF-kappaB activation [1].
  • Unlike IKKalpha, RIP4-deficient skin fails to fully differentiate when grafted onto a normal host [2].
  • RIP4 functions cell autonomously within the keratinocyte lineage [2].
  • RIP4 is a novel RIP (receptor-interacting protein) family kinase with ankyrin repeats cloned from a keratinocyte cDNA library [2].
  • The phenotype of RIP4(-/-) mice in part resembles that of mice lacking IKKalpha, a component of a complex that regulates NF-kappaB [2].

Biological context of Ripk4

  • Moreover, RIP4 is cleaved after Asp340 and Asp378 during Fas-induced apoptosis [3].

Regulatory relationships of Ripk4

  • RIP4 binds to several members of the TRAF protein family, and DN versions of TRAF1, TRAF3 and TRAF6 inhibit RIP4-induced NF-kappa B activation [3].

Other interactions of Ripk4

  • Overexpression of RIP4 leads to activation of NF-kappa B and JNK [3].
  • RIP4 contains an N-terminal RIP-like kinase domain and a C-terminal region characterized by the presence of 11 ankyrin repeats [3].
  • RIP4 deficiency in mice results in perinatal lethality associated with abnormal epidermal differentiation [2].


  1. A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development. Cariappa, A., Chen, L., Haider, K., Tang, M., Nebelitskiy, E., Moran, S.T., Pillai, S. J. Immunol. (2003) [Pubmed]
  2. RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation. Holland, P., Willis, C., Kanaly, S., Glaccum, M., Warren, A., Charrier, K., Murison, J., Derry, J., Virca, G., Bird, T., Peschon, J. Curr. Biol. (2002) [Pubmed]
  3. RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. Meylan, E., Martinon, F., Thome, M., Gschwendt, M., Tschopp, J. EMBO Rep. (2002) [Pubmed]
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