Gene Review:
Chuk - conserved helix-loop-helix ubiquitous kinase
Mus musculus
Synonyms:
AI256658, Chuk1, Conserved helix-loop-helix ubiquitous kinase, Fbx24, Fbxo24, ...
- The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. Dai, S., Hirayama, T., Abbas, S., Abu-Amer, Y. J. Biol. Chem. (2004)
- Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance. Kinoshita, D., Hirota, F., Kaisho, T., Kasai, M., Izumi, K., Bando, Y., Mouri, Y., Matsushima, A., Niki, S., Han, H., Oshikawa, K., Kuroda, N., Maegawa, M., Irahara, M., Takeda, K., Akira, S., Matsumoto, M. J. Immunol. (2006)
- Binding of manumycin A inhibits IkappaB kinase beta activity. Bernier, M., Kwon, Y.K., Pandey, S.K., Zhu, T.N., Zhao, R.J., Maciuk, A., He, H.J., Decabo, R., Kole, S. J. Biol. Chem. (2006)
- Limb and skin abnormalities in mice lacking IKKalpha. Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., Akira, S. Science (1999)
- Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells. Eddy, S.F., Guo, S., Demicco, E.G., Romieu-Mourez, R., Landesman-Bollag, E., Seldin, D.C., Sonenshein, G.E. Cancer Res. (2005)
- IkappaB kinase 2 inhibition corrects defective nitrergic erectile mechanisms in diabetic mouse corpus cavernosum. Nangle, M.R., Cotter, M.A., Cameron, N.E. Urology (2006)
- IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z.W., Egan, L.J., Kagnoff, M.F., Karin, M. Cell (2004)
- IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Hu, M.C., Lee, D.F., Xia, W., Golfman, L.S., Ou-Yang, F., Yang, J.Y., Zou, Y., Bao, S., Hanada, N., Saso, H., Kobayashi, R., Hung, M.C. Cell (2004)
- IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cao, Y., Bonizzi, G., Seagroves, T.N., Greten, F.R., Johnson, R., Schmidt, E.V., Karin, M. Cell (2001)
- IKK mediates ischemia-induced neuronal death. Herrmann, O., Baumann, B., de Lorenzi, R., Muhammad, S., Zhang, W., Kleesiek, J., Malfertheiner, M., Köhrmann, M., Potrovita, I., Maegele, I., Beyer, C., Burke, J.R., Hasan, M.T., Bujard, H., Wirth, T., Pasparakis, M., Schwaninger, M. Nat. Med. (2005)
- A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Anest, V., Hanson, J.L., Cogswell, P.C., Steinbrecher, K.A., Strahl, B.D., Baldwin, A.S. Nature (2003)
- Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. Clohisy, J.C., Yamanaka, Y., Faccio, R., Abu-Amer, Y. J. Orthop. Res. (2006)
- Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Broide, D.H., Lawrence, T., Doherty, T., Cho, J.Y., Miller, M., McElwain, K., McElwain, S., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. Syrovets, T., Gschwend, J.E., Büchele, B., Laumonnier, Y., Zugmaier, W., Genze, F., Simmet, T. J. Biol. Chem. (2005)
- Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer. Fern??ndez-Majada, V., Aguilera, C., Villanueva, A., Vilardell, F., Robert-Moreno, A., Ayt??s, A., Real, F.X., Capella, G., Mayo, M.W., Espinosa, L., Bigas, A. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Inhibition of JNK activation through NF-kappaB target genes. Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M., Lin, A. Nature (2001)
- Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Senftleben, U., Cao, Y., Xiao, G., Greten, F.R., Krähn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S.C., Karin, M. Science (2001)
- IkappaB kinase alpha is essential for mature B cell development and function. Kaisho, T., Takeda, K., Tsujimura, T., Kawai, T., Nomura, F., Terada, N., Akira, S. J. Exp. Med. (2001)
- IKK1-deficient mice exhibit abnormal development of skin and skeleton. Li, Q., Lu, Q., Hwang, J.Y., Büscher, D., Lee, K.F., Izpisua-Belmonte, J.C., Verma, I.M. Genes Dev. (1999)
- Mature T cells depend on signaling through the IKK complex. Schmidt-Supprian, M., Courtois, G., Tian, J., Coyle, A.J., Israël, A., Rajewsky, K., Pasparakis, M. Immunity (2003)
- I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. Ruocco, M.G., Maeda, S., Park, J.M., Lawrence, T., Hsu, L.C., Cao, Y., Schett, G., Wagner, E.F., Karin, M. J. Exp. Med. (2005)
- Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. Yan, F., Polk, D.B. J. Biol. Chem. (1999)
- Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. Castrillo, A., de Las Heras, B., Hortelano, S., Rodriguez, B., Villar, A., Bosca, L. J. Biol. Chem. (2001)
- Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. Gustin, J.A., Korgaonkar, C.K., Pincheira, R., Li, Q., Donner, D.B. J. Biol. Chem. (2006)
- Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. Funakoshi-Tago, M., Sonoda, Y., Tanaka, S., Hashimoto, K., Tago, K., Tominaga, S., Kasahara, T. J. Biol. Chem. (2003)
- Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A. Kray, A.E., Carter, R.S., Pennington, K.N., Gomez, R.J., Sanders, L.E., Llanes, J.M., Khan, W.N., Ballard, D.W., Wadzinski, B.E. J. Biol. Chem. (2005)
- Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. Khoshnan, A., Ko, J., Watkin, E.E., Paige, L.A., Reinhart, P.H., Patterson, P.H. J. Neurosci. (2004)
- IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation. Kwak, Y.T., Li, R., Becerra, C.R., Tripathy, D., Frenkel, E.P., Verma, U.N. J. Biol. Chem. (2005)
- Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. Rangaswami, H., Bulbule, A., Kundu, G.C. J. Biol. Chem. (2004)
- Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. Salmerón, A., Janzen, J., Soneji, Y., Bump, N., Kamens, J., Allen, H., Ley, S.C. J. Biol. Chem. (2001)
- Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. Panopoulos, A., Harraz, M., Engelhardt, J.F., Zandi, E. J. Biol. Chem. (2005)
- Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Li, Q., Lu, Q., Bottero, V., Estepa, G., Morrison, L., Mercurio, F., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Kundu, J.K., Shin, Y.K., Kim, S.H., Surh, Y.J. Carcinogenesis (2006)
- Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.F., Verma, I.M. Science (1999)
- RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. Yilmaz, Z.B., Weih, D.S., Sivakumar, V., Weih, F. EMBO J. (2003)
- Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Sakurai, T., Maeda, S., Chang, L., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Cao, Y., Luo, J.L., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Detection of a novel parasite kinase activity at the Toxoplasma gondii parasitophorous vacuole membrane capable of phosphorylating host IkappaBalpha. Molestina, R.E., Sinai, A.P. Cell. Microbiol. (2005)
- Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice. Song, Y.S., Lee, Y.S., Chan, P.H. J. Cereb. Blood Flow Metab. (2005)
- Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos. Falco, G., Stanghellini, I., Ko, M.S.h. Reprod. Biomed. Online (2006)