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Gene Review

Chuk  -  conserved helix-loop-helix ubiquitous kinase

Mus musculus

Synonyms: AI256658, Chuk1, Conserved helix-loop-helix ubiquitous kinase, Fbx24, Fbxo24, ...
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Disease relevance of Chuk


Psychiatry related information on Chuk


High impact information on Chuk


Chemical compound and disease context of Chuk


Biological context of Chuk


Anatomical context of Chuk


Associations of Chuk with chemical compounds


Physical interactions of Chuk

  • Transient expression of NF-kappaB-inducing kinase (NIK) activated the IKK complex and NF-kappaB, a process that was inhibited by kaurenes, indicating that the inhibition of NIK was one of the targets of these diterpenes [23].
  • This study shows that Akt binds to and increases the activity of IKKalpha and thereby increases p52 production in cells [24].
  • Also, TNF-induced association of FAK with RIP and subsequent association of RIP with TRAF2 were not observed, resulting in a failure of RIP to recruit the IKK complex in FAK-/- cells [25].
  • Second, PP2A forms stable complexes with IKK in untransfected mammalian cells [26].
  • Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity [27].

Enzymatic interactions of Chuk


Regulatory relationships of Chuk


Other interactions of Chuk

  • Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway [17].
  • These results show that IKK2 is essential for mouse development and cannot be substituted with IKK1 [34].
  • Our data indicate an important role of p52-RelB heterodimers in lymphoid organ development downstream of LTbetaR, NIK and IKKalpha [35].
  • In addition to underscoring the importance of JNK1-mediated hepatocyte death and compensatory proliferation, these results strongly suggest that the control of tissue renewal through the IKK and JNK pathways plays a key role in liver carcinogenesis [36].
  • Phosphorylation of a glutathione S-transferase-IkappaBalpha fusion protein by cellular extracts or immunoprecipitated IKKalpha isolated from cells treated with TNFalpha is inhibited by 5-ASA [22].
  • IKKalpha may represent a novel and specific target for treatment of ErbB2-positive breast cancer [37].

Analytical, diagnostic and therapeutic context of Chuk


  1. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. Dai, S., Hirayama, T., Abbas, S., Abu-Amer, Y. J. Biol. Chem. (2004) [Pubmed]
  2. Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance. Kinoshita, D., Hirota, F., Kaisho, T., Kasai, M., Izumi, K., Bando, Y., Mouri, Y., Matsushima, A., Niki, S., Han, H., Oshikawa, K., Kuroda, N., Maegawa, M., Irahara, M., Takeda, K., Akira, S., Matsumoto, M. J. Immunol. (2006) [Pubmed]
  3. Binding of manumycin A inhibits IkappaB kinase beta activity. Bernier, M., Kwon, Y.K., Pandey, S.K., Zhu, T.N., Zhao, R.J., Maciuk, A., He, H.J., Decabo, R., Kole, S. J. Biol. Chem. (2006) [Pubmed]
  4. Limb and skin abnormalities in mice lacking IKKalpha. Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., Akira, S. Science (1999) [Pubmed]
  5. Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells. Eddy, S.F., Guo, S., Demicco, E.G., Romieu-Mourez, R., Landesman-Bollag, E., Seldin, D.C., Sonenshein, G.E. Cancer Res. (2005) [Pubmed]
  6. IkappaB kinase 2 inhibition corrects defective nitrergic erectile mechanisms in diabetic mouse corpus cavernosum. Nangle, M.R., Cotter, M.A., Cameron, N.E. Urology (2006) [Pubmed]
  7. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z.W., Egan, L.J., Kagnoff, M.F., Karin, M. Cell (2004) [Pubmed]
  8. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Hu, M.C., Lee, D.F., Xia, W., Golfman, L.S., Ou-Yang, F., Yang, J.Y., Zou, Y., Bao, S., Hanada, N., Saso, H., Kobayashi, R., Hung, M.C. Cell (2004) [Pubmed]
  9. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cao, Y., Bonizzi, G., Seagroves, T.N., Greten, F.R., Johnson, R., Schmidt, E.V., Karin, M. Cell (2001) [Pubmed]
  10. IKK mediates ischemia-induced neuronal death. Herrmann, O., Baumann, B., de Lorenzi, R., Muhammad, S., Zhang, W., Kleesiek, J., Malfertheiner, M., Köhrmann, M., Potrovita, I., Maegele, I., Beyer, C., Burke, J.R., Hasan, M.T., Bujard, H., Wirth, T., Pasparakis, M., Schwaninger, M. Nat. Med. (2005) [Pubmed]
  11. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Anest, V., Hanson, J.L., Cogswell, P.C., Steinbrecher, K.A., Strahl, B.D., Baldwin, A.S. Nature (2003) [Pubmed]
  12. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. Clohisy, J.C., Yamanaka, Y., Faccio, R., Abu-Amer, Y. J. Orthop. Res. (2006) [Pubmed]
  13. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Broide, D.H., Lawrence, T., Doherty, T., Cho, J.Y., Miller, M., McElwain, K., McElwain, S., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. Syrovets, T., Gschwend, J.E., Büchele, B., Laumonnier, Y., Zugmaier, W., Genze, F., Simmet, T. J. Biol. Chem. (2005) [Pubmed]
  15. Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer. Fern??ndez-Majada, V., Aguilera, C., Villanueva, A., Vilardell, F., Robert-Moreno, A., Ayt??s, A., Real, F.X., Capella, G., Mayo, M.W., Espinosa, L., Bigas, A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  16. Inhibition of JNK activation through NF-kappaB target genes. Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M., Lin, A. Nature (2001) [Pubmed]
  17. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Senftleben, U., Cao, Y., Xiao, G., Greten, F.R., Krähn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S.C., Karin, M. Science (2001) [Pubmed]
  18. IkappaB kinase alpha is essential for mature B cell development and function. Kaisho, T., Takeda, K., Tsujimura, T., Kawai, T., Nomura, F., Terada, N., Akira, S. J. Exp. Med. (2001) [Pubmed]
  19. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Li, Q., Lu, Q., Hwang, J.Y., Büscher, D., Lee, K.F., Izpisua-Belmonte, J.C., Verma, I.M. Genes Dev. (1999) [Pubmed]
  20. Mature T cells depend on signaling through the IKK complex. Schmidt-Supprian, M., Courtois, G., Tian, J., Coyle, A.J., Israël, A., Rajewsky, K., Pasparakis, M. Immunity (2003) [Pubmed]
  21. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. Ruocco, M.G., Maeda, S., Park, J.M., Lawrence, T., Hsu, L.C., Cao, Y., Schett, G., Wagner, E.F., Karin, M. J. Exp. Med. (2005) [Pubmed]
  22. Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. Yan, F., Polk, D.B. J. Biol. Chem. (1999) [Pubmed]
  23. Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK. Castrillo, A., de Las Heras, B., Hortelano, S., Rodriguez, B., Villar, A., Bosca, L. J. Biol. Chem. (2001) [Pubmed]
  24. Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. Gustin, J.A., Korgaonkar, C.K., Pincheira, R., Li, Q., Donner, D.B. J. Biol. Chem. (2006) [Pubmed]
  25. Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. Funakoshi-Tago, M., Sonoda, Y., Tanaka, S., Hashimoto, K., Tago, K., Tominaga, S., Kasahara, T. J. Biol. Chem. (2003) [Pubmed]
  26. Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A. Kray, A.E., Carter, R.S., Pennington, K.N., Gomez, R.J., Sanders, L.E., Llanes, J.M., Khan, W.N., Ballard, D.W., Wadzinski, B.E. J. Biol. Chem. (2005) [Pubmed]
  27. Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. Khoshnan, A., Ko, J., Watkin, E.E., Paige, L.A., Reinhart, P.H., Patterson, P.H. J. Neurosci. (2004) [Pubmed]
  28. IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation. Kwak, Y.T., Li, R., Becerra, C.R., Tripathy, D., Frenkel, E.P., Verma, U.N. J. Biol. Chem. (2005) [Pubmed]
  29. Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. Rangaswami, H., Bulbule, A., Kundu, G.C. J. Biol. Chem. (2004) [Pubmed]
  30. Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. Salmerón, A., Janzen, J., Soneji, Y., Bump, N., Kamens, J., Allen, H., Ley, S.C. J. Biol. Chem. (2001) [Pubmed]
  31. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. Panopoulos, A., Harraz, M., Engelhardt, J.F., Zandi, E. J. Biol. Chem. (2005) [Pubmed]
  32. Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Li, Q., Lu, Q., Bottero, V., Estepa, G., Morrison, L., Mercurio, F., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  33. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Kundu, J.K., Shin, Y.K., Kim, S.H., Surh, Y.J. Carcinogenesis (2006) [Pubmed]
  34. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.F., Verma, I.M. Science (1999) [Pubmed]
  35. RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. Yilmaz, Z.B., Weih, D.S., Sivakumar, V., Weih, F. EMBO J. (2003) [Pubmed]
  36. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Sakurai, T., Maeda, S., Chang, L., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  37. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Cao, Y., Luo, J.L., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  38. Detection of a novel parasite kinase activity at the Toxoplasma gondii parasitophorous vacuole membrane capable of phosphorylating host IkappaBalpha. Molestina, R.E., Sinai, A.P. Cell. Microbiol. (2005) [Pubmed]
  39. Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice. Song, Y.S., Lee, Y.S., Chan, P.H. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  40. Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos. Falco, G., Stanghellini, I., Ko, M.S.h. Reprod. Biomed. Online (2006) [Pubmed]
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