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Gene Review

UQCRC1  -  ubiquinol-cytochrome c reductase core...

Homo sapiens

Synonyms: Complex III subunit 1, Core protein I, Cytochrome b-c1 complex subunit 1, mitochondrial, D3S3191, QCR1, ...
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High impact information on UQCRC1

  • In support of these studies we demonstrate that Nogo interacts with the UQCRC1 and UQCRC2 components of complex III, within the mitochondrial respiratory chain [1].
  • We found that (1) UQCRC1 was highly expressed in breast (74%) and ovarian tumors (34%) and (2) the expression positively correlated with cytochrome c-oxidase (COXII) encoded by mtDNA [2].
  • To determine a potential role for identified retrograde responsive proteins in tumorigenesis, we analyzed the expression of UQCRC1 gene (encoding ubiquinol cytochrome-c reductase core protein I) in breast and ovarian tumors [2].


  1. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). Hu, W.H., Hausmann, O.N., Yan, M.S., Walters, W.M., Wong, P.K., Bethea, J.R. J. Neurochem. (2002) [Pubmed]
  2. Proteomic Analysis of Mitochondria-to-Nucleus Retrograde Response in Human Cancer. Kulawiec, M., Arnouk, H., Desouki, M.M., Kazim, L., Still, I., Singh, K.K. Cancer Biol. Ther. (2006) [Pubmed]
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