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MT-CO2  -  mitochondrially encoded cytochrome c...

Homo sapiens

Synonyms: CO2, COII, COX2, COXII, Cytochrome c oxidase polypeptide II, ...
 
 
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Disease relevance of MT-CO2

 

Psychiatry related information on MT-CO2

 

High impact information on MT-CO2

  • Here, we developed a new genetic mouse model of selective COX2 inhibition using a gene-targeted point mutation, resulting in a Y385F substitution [10].
  • Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celecoxib, a COX-2-selective NSAID [11].
  • We have sequenced a 5'-end proximal segment of the putative COII mRNA from HeLa cells of about 30 nucleotides and have aligned it with the COII coding sequence in human mtDNA [12].
  • Many of aspirin's therapeutic effects arise from its acetylation of cyclooxygenase-2 (COX-2), whereas its antithrombotic and ulcerogenic effects result from its acetylation of COX-1 [13].
  • CONTEXT: Osteoarthritis (OA) is often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or specific inhibitors of cyclooxygenase 2 (COX-2) [14].
 

Chemical compound and disease context of MT-CO2

 

Biological context of MT-CO2

 

Anatomical context of MT-CO2

 

Associations of MT-CO2 with chemical compounds

 

Regulatory relationships of MT-CO2

 

Other interactions of MT-CO2

  • SCO1-deficient cells contained accumulated levels of the MTCO1.COX4.COX5A subassembly, suggesting that MTCO2 associates with the MTCO1.COX4.COX5A subassembly after the Cu(A) center of MTCO2 is formed [33].
  • In parallel, total RNA was extracted from samples of dissected heart and analyzed by Northern blot hybridization to determine the steady-state level of three RNA transcripts encoded by the COXII, COXIII, and COXIV genes [34].
  • Cytochrome c oxidase subunit II was reduced proportionally to COX I, indicating impairment in complex assembly [35].
  • The species range and the overall magnitude of this rate increase are similar to those previously identified for the cytochrome c oxidase subunit II and cytochrome b genes [36].
  • The activation of both ERK and PI3-K was essential for HRG regulation of COXII, i.e., blockage of either pathway eliminated HRG-mediated alteration [37].
 

Analytical, diagnostic and therapeutic context of MT-CO2

  • Total RNA was isolated using phenolchloroform, and reverse transcription-polymerase chain reaction (RT-PCR) was performed using primers specific for OPG, RANKL, COX2, Cbfa1, and aldolase, with amplification in the exponential range for each molecule studied [38].
  • Despite the numerous studies on COX2 inhibitors that have emerged, drawing conclusions about their cardiovascular safety has been complicated by conflicting results, underpowered clinical trials, and the lack of a placebo group and use of post hoc analyses in many trials [39].
  • The production of COX2 and proinflammatory cytokines was investigated by reverse transcriptase (RT)-PCR and ELISA assay in macrophages stimulated by lipopolysaccharide (LPS) [25].
  • The cyclooxygenase-2 (COX-2) inhibitor celecoxib is an approved drug in the clinic for colon cancer chemoprevention and has been tested for its chemopreventive and therapeutic efficacy in various clinical trials [15].
  • Reactive oxygen species (ROS), measured by flow cytometry, were increased by COX-2 overexpression in Saos-2 cells but not in HCT-116 cells [40].

References

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