Gene Review:
MT-CO2 - mitochondrially encoded cytochrome c...
Homo sapiens
Synonyms:
CO2, COII, COX2, COXII, Cytochrome c oxidase polypeptide II, ...
- Inflammation and IGF-I activate the Akt pathway in breast cancer. Prueitt, R.L., Boersma, B.J., Howe, T.M., Goodman, J.E., Thomas, D.D., Ying, L., Pfiester, C.M., Yfantis, H.G., Cottrell, J.R., Lee, D.H., Remaley, A.T., Hofseth, L.J., Wink, D.A., Ambs, S. Int. J. Cancer (2007)
- Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Cox, D.G., Pontes, C., Guino, E., Navarro, M., Osorio, A., Canzian, F., Moreno, V. Br. J. Cancer (2004)
- Pulmonary cryptosporidiosis: role of COX2 and NF-kB. Asaad, N.Y., Sadek, G.S. APMIS (2006)
- Immunoexpression of multidrug-resistance protein 2 and cyclooxygenase 2 in medullary thyroid carcinomas. Ruggeri, R.M., Sciacchitano, S., Vitarelli, E., Trimarchi, F., Barresi, G., Trovato, M. Arch. Pathol. Lab. Med. (2006)
- Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. Oka, A., Takashima, S. Neuroreport (1997)
- Long-term efficacy and safety of celecoxib in Alzheimer's disease. Soininen, H., West, C., Robbins, J., Niculescu, L. Dementia and geriatric cognitive disorders (2007)
- Cyclooxygenase-2 inhibitors: a painful lesson. Sanghi, S., MacLaughlin, E.J., Jewell, C.W., Chaffer, S., Naus, P.J., Watson, L.E., Dostal, D.E. Cardiovascular & hematological disorders drug targets. (2006)
- Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion. Schmidtko, A., Burian, M., Altis, K., Hardt, K., Angioni, C., Schmidt, R., Podda, M., Geisslinger, G. Pain (2007)
- Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Martin, T.J., Buechler, N.L., Eisenach, J.C. Anesth. Analg. (2006)
- Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Yu, Y., Fan, J., Chen, X.S., Wang, D., Klein-Szanto, A.J., Campbell, R.L., FitzGerald, G.A., Funk, C.D. Nat. Med. (2006)
- Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Kukar, T., Murphy, M.P., Eriksen, J.L., Sagi, S.A., Weggen, S., Smith, T.E., Ladd, T., Khan, M.A., Kache, R., Beard, J., Dodson, M., Merit, S., Ozols, V.V., Anastasiadis, P.Z., Das, P., Fauq, A., Koo, E.H., Golde, T.E. Nat. Med. (2005)
- The putative mRNA for subunit II of human cytochrome c oxidase starts directly at the translation initiator codon. Ojala, D.K., Montoya, J., Attardi, G. Nature (1980)
- Aspirin-like molecules that covalently inactivate cyclooxygenase-2. Kalgutkar, A.S., Crews, B.C., Rowlinson, S.W., Garner, C., Seibert, K., Marnett, L.J. Science (1998)
- Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. Geba, G.P., Weaver, A.L., Polis, A.B., Dixon, M.E., Schnitzer, T.J. JAMA (2002)
- Cellular FLICE-Inhibitory Protein Down-regulation Contributes to Celecoxib-Induced Apoptosis in Human Lung Cancer Cells. Liu, X., Yue, P., Sch??nthal, A.H., Khuri, F.R., Sun, S.Y. Cancer Res. (2006)
- Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Sun, Y., Tang, X.M., Half, E., Kuo, M.T., Sinicrope, F.A. Cancer Res. (2002)
- Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Ho, Y.C., Chang, Y.C. Acta Pharmacol. Sin. (2006)
- Etoricoxib in the treatment of chronic pain. Duncan, M.R., Capell, H.A. International journal of clinical practice. (2003)
- Cyclooxygenase-2 Inhibition Suppresses {alpha}v{beta}6 Integrin-Dependent Oral Squamous Carcinoma Invasion. Nystrom, M.L., McCulloch, D., Weinreb, P.H., Violette, S.M., Speight, P.M., Marshall, J.F., Hart, I.R., Thomas, G.J. Cancer Res. (2006)
- Changing expression of cyclooxygenases and prostaglandin receptor EP4 during development of the human ductus arteriosus. Rheinlaender, C., Weber, S.C., Sarioglu, N., Strauss, E., Obladen, M., Koehne, P. Pediatr. Res. (2006)
- The decline in testosterone biosynthesis during male aging: a consequence of multiple alterations. Wang, X., Stocco, D.M. Mol. Cell. Endocrinol. (2005)
- Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. Pellagatti, A., Esoof, N., Watkins, F., Langford, C.F., Vetrie, D., Campbell, L.J., Fidler, C., Cavenagh, J.D., Eagleton, H., Gordon, P., Woodcock, B., Pushkaran, B., Kwan, M., Wainscoat, J.S., Boultwood, J. Br. J. Haematol. (2004)
- Cyclooxygenases in rat Leydig cells: effects of luteinizing hormone and aging. Chen, H., Luo, L., Liu, J., Zirkin, B.R. Endocrinology (2007)
- IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes. Litherland, S.A., Xie, T.X., Grebe, K.M., Li, Y., Moldawer, L.L., Clare-Salzler, M.J. J. Autoimmun. (2004)
- Silica-ceramic suppresses the expression of proinflammatory cytokines induced by lipopolysaccharide in macrophages. Hwang, M., Park, K.K., Chang, Y.C., Choo, Y.A., Jeon, J.P., Shin, I.H., Lee, T.S. Journal of biomedical materials research. Part A (2007)
- Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum. Alloza, I., Baxter, A., Chen, Q., Matthiesen, R., Vandenbroeck, K. Mol. Pharmacol. (2006)
- The future of targeted therapy: combining novel agents. Gianni, L. Oncology (2002)
- A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2). Huff, R., Collins, P., Kramer, S., Seibert, K., Koboldt, C., Gregory, S., Isakson, P. Inflamm. Res. (1995)
- A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. Cox, D.G., Buring, J., Hankinson, S.E., Hunter, D.J. Breast Cancer Res. (2007)
- Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells. Niederberger, E., Manderscheid, C., Grösch, S., Schmidt, H., Ehnert, C., Geisslinger, G. Biochem. Pharmacol. (2004)
- Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agents. Rodríguez-Burford, C., Barnes, M.N., Oelschlager, D.K., Myers, R.B., Talley, L.I., Partridge, E.E., Grizzle, W.E. Clin. Cancer Res. (2002)
- Mitochondrial distribution and function in herpes simplex virus-infected cells. Murata, T., Goshima, F., Daikoku, T., Inagaki-Ohara, K., Takakuwa, H., Kato, K., Nishiyama, Y. J. Gen. Virol. (2000)
- Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1. Williams, S.L., Valnot, I., Rustin, P., Taanman, J.W. J. Biol. Chem. (2004)
- Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice: suppression of cytochrome c oxidase II gene expression. Papadopoulou, L.C., Theophilidis, G., Thomopoulos, G.N., Tsiftsoglou, A.S. Biochem. Pharmacol. (1999)
- In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I. D'Aurelio, M., Pallotti, F., Barrientos, A., Gajewski, C.D., Kwong, J.Q., Bruno, C., Beal, M.F., Manfredi, G. J. Biol. Chem. (2001)
- Evolutionary rate acceleration of cytochrome c oxidase subunit I in simian primates. Andrews, T.D., Easteal, S. J. Mol. Evol. (2000)
- Induction or suppression of expression of cytochrome C oxidase subunit II by heregulin beta 1 in human mammary epithelial cells is dependent on the levels of ErbB2 expression. Sun, Y., Lin, H., Zhu, Y., Ma, C., Ye, J., Luo, J. J. Cell. Physiol. (2002)
- Effects of enamel matrix derivative on bone-related mRNA expression in human periodontal ligament cells in vitro. Takayanagi, K., Osawa, G., Nakaya, H., Cochran, D.L., Kamoi, K., Oates, T.W. J. Periodontol. (2006)
- Coxibs and heart disease: what we have learned and what else we need to know. Zarraga, I.G., Schwarz, E.R. J. Am. Coll. Cardiol. (2007)
- Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. Xu, Z., Choudhary, S., Voznesensky, O., Mehrotra, M., Woodard, M., Hansen, M., Herschman, H., Pilbeam, C. Cancer Res. (2006)