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Gene Review

KDM6A  -  lysine (K)-specific demethylase 6A

Homo sapiens

Synonyms: Histone demethylase UTX, KABUK2, Lysine-specific demethylase 6A, UTX, Ubiquitously-transcribed TPR protein on the X chromosome, ...
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UTX - a JmjC domain containing histone demethylase

  • UTX has two alternatively spliced isoforms and escapes X inactivation in mice and humans [5]
  • UTX has been found in a Set1 like complex, with PTIP and other proteins. This complex mediates histone H3K4 methylation [6].
  • UTX shows high similarity to UTY (>80%) which is in the non-recombining region of the Y chromosome (NRY)

UTX/UTY amplification for sexing primates


  1. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Hong, S., Cho, Y.W., Yu, L.R., Yu, H., Veenstra, T.D., Ge, K. Proc. Natl. Acad. Sci. U. S. A. (2007) [Pubmed]
  2. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger, K., Cloos, P.A., Christensen, J., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A.E., Helin, K. Nature. (2007) [Pubmed]
  3. A histone H3 lysine 27 demethylase regulates animal posterior development. Lan, F., Bayliss, P.E., Rinn, J.L., Whetstine, J.R., Wang, J.K., Chen, S., Iwase, S., Alpatov, R., Issaeva, I., Canaani, E., Roberts, T.M., Chang, H.Y., Shi, Y. Nature. (2007) [Pubmed]
  4. H3K27 demethylases, at long last. Swigut, T., Wysocka, J. Cell. (2007) [Pubmed]
  5. The UTX gene escapes X inactivation in mice and humans. Greenfield, A., Carrel, L., Pennisi, D., Philippe, C., Quaderi, N., Siggers, P., Steiner, K., Tam, P.P., Monaco, A.P., Willard, H.F., Koopman, P. Hum. Mol. Genet. (1998) [Pubmed]
  6. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. Cho, Y.W., Hong, T., Hong, S., Guo, H., Yu, H., Kim, D., Guszczynski, T., Dressler, G.R., Copeland, T.D., Kalkum, M., Ge, K. J. Biol. Chem. (2007) [Pubmed]
  7. Fast and non-invasive PCR sexing of primates: apes, Old World monkeys, New World monkeys and Strepsirrhines. Villesen, P., Fredsted, T. BMC ecology [electronic resource]. (2006) [Pubmed]
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