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Gene Review:

UTY - ubiquitously transcribed tetratricopeptide...

Homo sapiens

Synonyms: Histone demethylase UTY, KDM6AL, KDM6C, UTY1, Ubiquitously-transcribed TPR protein on the Y chromosome, ...

Vogt, M.H. et al., Villesen, P. et al., Simpson, E., Foresta, C. et al., Ginalski, K. et al., et al.

Shen, Wang, Underhill, Franco, Yang, Roxas, Sung, Lin, Hyman, Vollrath, Davis, Cavalli-Sforza, Oefner, Foresta, Moro, Rossi, Rossato, Garolla, Ferlin, Vogt, Goulmy, Kloosterboer, Blokland, de Paus, Willemze, Falkenburg, Ginalski, Rychlewski, Baker, Grishin, Simpson, Villesen, Fredsted,

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High impact information on UTY

The most challenging predictions include the unexpected but confident 3D structure assignments for three domains identified here encoded by the USP9Y, UTY, and BPY2 genes [1].
The unfinished sequencing of the 5' portion of gene UTY1 was completed by primer walking, and a total of 20 exons were found [2].
The UTY-derived H-Y antigen was characterized as a 10-amino acid residue peptide, RESEEESVSL [3].
UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition [3].
UTY-specific TCR-transfer generates potential graft-versus-leukaemia effector T cells [4].

Biological context of UTY

It contains three genes, USP9Y, DBY and UTY, but only the former two can be at present considered candidate genes for the infertile phenotype associated with deletion of this interval [5].

Anatomical context of UTY

The human homologues SMCY and UTY likewise express HY antigens and these are targets of damaging graft-versus-host (GVH) responses and potentially therapeutic graft-versus-leukaemia (GVL) responses following bone marrow transplantation (BMT) [6].

Other interactions of UTY

The region includes the genes USP9Y, DBY and UTY and is limited by evolutionary breakpoints within the PAC clones 41L06 and 46M11 [7].
RESULTS: A novel method for sex identification in primates is described using a triple primer PCR reaction and agarose gel electrophoresis of the sex-chromosomal isoforms of the ubiquitously transcribed tetratricopeptide repeat protein gene (UTX/UTY) [8].

References

Protein structure prediction for the male-specific region of the human Y chromosome. Ginalski, K., Rychlewski, L., Baker, D., Grishin, N.V. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Population genetic implications from sequence variation in four Y chromosome genes. Shen, P., Wang, F., Underhill, P.A., Franco, C., Yang, W.H., Roxas, A., Sung, R., Lin, A.A., Hyman, R.W., Vollrath, D., Davis, R.W., Cavalli-Sforza, L.L., Oefner, P.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition. Vogt, M.H., Goulmy, E., Kloosterboer, F.M., Blokland, E., de Paus, R.A., Willemze, R., Falkenburg, J.H. Blood (2000) [Pubmed]
UTY-specific TCR-transfer generates potential graft-versus-leukaemia effector T cells. Ivanov, R., Hol, S., Aarts, T., Hagenbeek, A., Slager, E.H., Ebeling, S. Br. J. Haematol. (2005) [Pubmed]
Role of the AZFa candidate genes in male infertility. Foresta, C., Moro, E., Rossi, A., Rossato, M., Garolla, A., Ferlin, A. J. Endocrinol. Invest. (2000) [Pubmed]
The case of the midwife scientist. Simpson, E. Int. J. Dev. Biol. (2001) [Pubmed]
The Azoospermia region AZFa: an evolutionar y view. Wimmer, R., Kirsch, S., Weber, A., Rappold, G.A., Schempp, W. Cytogenet. Genome Res. (2002) [Pubmed]
Fast and non-invasive PCR sexing of primates: apes, Old World monkeys, New World monkeys and Strepsirrhines. Villesen, P., Fredsted, T. BMC ecology [electronic resource]. (2006) [Pubmed]

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