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Gene Review

Chpf  -  chondroitin polymerizing factor

Mus musculus

Synonyms: 1700028N03Rik, AI414328, ChPF, Chondroitin glucuronyltransferase 2, Chondroitin sulfate synthase 2, ...
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Disease relevance of D1Bwg1363e


High impact information on D1Bwg1363e


Biological context of D1Bwg1363e

  • By subjecting mice of these three groups to genetic analysis, the strain of the first group (WHT/Ht mice) was demonstrated to be a recessive homozygote which had a single autosomal defective gene making it unable to express N-acetylgalactosaminyltransferase activity to produce II3NeuGc-GgOse3Cer [7].

Other interactions of D1Bwg1363e

  • Mice with a disrupted Galgt1 gene lack UDP-GalNAc:GM3/GD3 N-acetylgalactosaminyltransferase (GM2/GD2 synthase) and fail to express complex brain gangliosides, including GD1a and GT1b, instead expressing a comparable amount of the simpler gangliosides GM3, GD3, and O-acetyl-GD3 [8].


  1. Effect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells. Bieberich, E., Tencomnao, T., Kapitonov, D., Yu, R.K. J. Neurochem. (2000) [Pubmed]
  2. Glycolipid N-acetylgalactosaminyltransferase activities in normal and Kirsten murine sarcoma virus transformed BALB/c 3T3 cells. Lockney, M.W., Soltysiak, R.M., Sweeley, C.C. Adv. Exp. Med. Biol. (1982) [Pubmed]
  3. Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Mohlke, K.L., Purkayastha, A.A., Westrick, R.J., Smith, P.L., Petryniak, B., Lowe, J.B., Ginsburg, D. Cell (1999) [Pubmed]
  4. Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver. Hashimoto, Y., Sekine, M., Iwasaki, K., Suzuki, A. J. Biol. Chem. (1993) [Pubmed]
  5. Coordinate regulation of ganglioside glycosyltransferases in differentiating NG108-15 neuroblastoma x glioma cells. Walton, K.M., Schnaar, R.L. J. Neurochem. (1989) [Pubmed]
  6. Glycosylation of recombinant ancrod from Agkistrodon rhodostoma after expression in mouse epithelial cells. Geyer, H., Jacobi, I., Linder, D., Stirm, S., Bialojan, S., Strube, K.H., Geyer, R. Eur. J. Biochem. (1996) [Pubmed]
  7. Genetic control of glycolipid expression. Yamakawa, T., Suzuki, A., Hashimoto, Y. Chem. Phys. Lipids (1986) [Pubmed]
  8. Myelin-associated glycoprotein (Siglec-4) expression is progressively and selectively decreased in the brains of mice lacking complex gangliosides. Sun, J., Shaper, N.L., Itonori, S., Heffer-Lauc, M., Sheikh, K.A., Schnaar, R.L. Glycobiology (2004) [Pubmed]
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