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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZFPL1  -  zinc finger protein-like 1

Homo sapiens

Synonyms: D11S750, MCG4, Zinc finger protein MCG4, Zinc finger protein-like 1
 
 
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High impact information on ZFPL1

  • The VRF gene maps to the D11S750 locus at chromosome band 11q13, and the protein coding region, spanning approximately 5 kb, is comprised of 8 exons that range in size from 36 to 431 bp [1].
  • However, zinc-finger-like domains and leucine-zipper-like motifs in the predicted ZFPL1 protein were identified, suggesting the presence of DNA-binding and dimerization domains possibly involved in transcription regulation [2].
  • A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1 [2].
  • The human VEGF related factor (VRF) gene was initially isolated using an 11q13 specific cosmid probe (D11S750) [3].

References

  1. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. Grimmond, S., Lagercrantz, J., Drinkwater, C., Silins, G., Townson, S., Pollock, P., Gotley, D., Carson, E., Rakar, S., Nordenskjöld, M., Ward, L., Hayward, N., Weber, G. Genome Res. (1996) [Pubmed]
  2. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. Höppener, J.W., De Wit, M.J., Simarro-Doorten, A.Y., Roijers, J.F., van Herrewaarden, H.M., Lips, C.J., Parente, F., Quincey, D., Gaudray, P., Khodaei, S., Weber, G., Teh, B., Farnebo, F., Larsson, C., Zhang, C.X., Calender, A., Pannett, A.A., Forbes, S.A., Bassett, J.H., Thakker, R.V., Lemmens, I., Van de Ven, W.J., Kas, K. Genomics (1998) [Pubmed]
  3. Expression of the VEGF-related factor gene in pre- and postnatal mouse. Lagercrantz, J., Larsson, C., Grimmond, S., Fredriksson, M., Weber, G., Piehl, F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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