The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

VEGFB  -  vascular endothelial growth factor B

Homo sapiens

Synonyms: VEGF-B, VEGF-related factor, VEGFL, VRF, Vascular endothelial growth factor B
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of VEGFB


Psychiatry related information on VEGFB


High impact information on VEGFB


Biological context of VEGFB


Anatomical context of VEGFB


Associations of VEGFB with chemical compounds


Physical interactions of VEGFB

  • The NRP1 binding of VEGF-B could be competed by an excess of VEGF(165) [15].

Regulatory relationships of VEGFB


Other interactions of VEGFB


Analytical, diagnostic and therapeutic context of VEGFB


  1. Expression of vascular endothelial growth factor-b in human astrocytoma. Gollmer, J.C., Ladoux, A., Gioanni, J., Paquis, P., Dubreuil, A., Chatel, M., Frelin, C. Neuro-oncology (2000) [Pubmed]
  2. Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: regulation by the von Hippel-Lindau gene and hypoxia. Gunningham, S.P., Currie, M.J., Han, C., Turner, K., Scott, P.A., Robinson, B.A., Harris, A.L., Fox, S.B. Cancer Res. (2001) [Pubmed]
  3. Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding. Iyer, S., Scotney, P.D., Nash, A.D., Ravi Acharya, K. J. Mol. Biol. (2006) [Pubmed]
  4. Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Xu, Q., Ohara, N., Chen, W., Liu, J., Sasaki, H., Morikawa, A., Sitruk-Ware, R., Johansson, E.D., Maruo, T. Hum. Reprod. (2006) [Pubmed]
  5. An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors. Kumar, V., Anand, R., Messina, J., Hartman, R., Veach, J. Eur. J. Neurol. (2000) [Pubmed]
  6. Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. Paavonen, K., Horelli-Kuitunen, N., Chilov, D., Kukk, E., Pennanen, S., Kallioniemi, O.P., Pajusola, K., Olofsson, B., Eriksson, U., Joukov, V., Palotie, A., Alitalo, K. Circulation (1996) [Pubmed]
  7. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Yang, A.D., Camp, E.R., Fan, F., Shen, L., Gray, M.J., Liu, W., Somcio, R., Bauer, T.W., Wu, Y., Hicklin, D.J., Ellis, L.M. Cancer Res. (2006) [Pubmed]
  8. Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa. André, T., Kotelevets, L., Vaillant, J.C., Coudray, A.M., Weber, L., Prévot, S., Parc, R., Gespach, C., Chastre, E. Int. J. Cancer (2000) [Pubmed]
  9. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. Grimmond, S., Lagercrantz, J., Drinkwater, C., Silins, G., Townson, S., Pollock, P., Gotley, D., Carson, E., Rakar, S., Nordenskjöld, M., Ward, L., Hayward, N., Weber, G. Genome Res. (1996) [Pubmed]
  10. Comparative expression of vascular endothelial growth factor family members, VEGF-B, -C and -D, by normal human keratinocytes and fibroblasts. Trompezinski, S., Berthier-Vergnes, O., Denis, A., Schmitt, D., Viac, J. Exp. Dermatol. (2004) [Pubmed]
  11. Localisation of members of the vascular endothelial growth factor (VEGF) family and their receptors in human atherosclerotic arteries. Belgore, F., Blann, A., Neil, D., Ahmed, A.S., Lip, G.Y. J. Clin. Pathol. (2004) [Pubmed]
  12. VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis. Gunningham, S.P., Currie, M.J., Han, C., Robinson, B.A., Scott, P.A., Harris, A.L., Fox, S.B. J. Pathol. (2001) [Pubmed]
  13. Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase. Wheeler-Jones, C., Abu-Ghazaleh, R., Cospedal, R., Houliston, R.A., Martin, J., Zachary, I. FEBS Lett. (1997) [Pubmed]
  14. Sonic intelligence as a virtual therapeutic environment. Tarnanas, I., Adam, D. Cyberpsychology & behavior : the impact of the Internet, multimedia and virtual reality on behavior and society. (2003) [Pubmed]
  15. Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. Makinen, T., Olofsson, B., Karpanen, T., Hellman, U., Soker, S., Klagsbrun, M., Eriksson, U., Alitalo, K. J. Biol. Chem. (1999) [Pubmed]
  16. Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines. Wey, J.S., Fan, F., Gray, M.J., Bauer, T.W., McCarty, M.F., Somcio, R., Liu, W., Evans, D.B., Wu, Y., Hicklin, D.J., Ellis, L.M. Cancer (2005) [Pubmed]
  17. Brain-derived neurotrophic factor enhances periodontal tissue regeneration. Takeda, K., Shiba, H., Mizuno, N., Hasegawa, N., Mouri, Y., Hirachi, A., Yoshino, H., Kawaguchi, H., Kurihara, H. Tissue engineering. (2005) [Pubmed]
  18. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. Ristimäki, A., Narko, K., Enholm, B., Joukov, V., Alitalo, K. J. Biol. Chem. (1998) [Pubmed]
  19. Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis. Stearns, M.E., Wang, M., Hu, Y., Kim, G., Garcia, F.U. Lab. Invest. (2004) [Pubmed]
  20. Serum vascular endothelial growth factor C (VEGF-C) as a specific biomarker for advanced cervical cancer: Relationship to insulin-like growth factor II (IGF-II), IGF binding protein 3 (IGF-BP3) and VEGF-B. Mathur, S.P., Mathur, R.S., Gray, E.A., Lane, D., Underwood, P.G., Kohler, M., Creasman, W.T. Gynecol. Oncol. (2005) [Pubmed]
  21. Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. Sawa, H., Murakami, H., Ohshima, Y., Murakami, M., Yamazaki, I., Tamura, Y., Mima, T., Satone, A., Ide, W., Hashimoto, I., Kamada, H. Brain tumor pathology. (2002) [Pubmed]
WikiGenes - Universities