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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZNF711  -  zinc finger protein 711

Homo sapiens

Synonyms: CMPX1, MRX97, ZNF4, ZNF5, ZNF6, ...
 
 
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High impact information on ZNF711

  • ZNF6 has an unusually large 5' untranslated region (UTR) of 1.2 Kb which contains 26 potential ATG initiation codons, only one of which is associated with a long open reading frame [1].
  • Possible origins of ZFX, ZFY and CMPX1 from a common ancestral gene are discussed [1].
  • In the present work, the zinc finger gene, ZNF6, has been shown to lie within this region and to be highly expressed in brain, making it a good candidate MR gene [2].
  • Znc6 shows aa homology of 88% to the protein encoded by the zinc finger exon of the human ZFY-related gene, ZNF6, recently found on the X chromosome [3].

References

  1. An X-linked zinc finger gene mapping to Xq21.1-q21.3 closely related to ZFX and ZFY: possible origins from a common ancestral gene. Lloyd, S.L., Sargent, C.A., Chalmers, J., Lim, E., Habeebu, S.S., Affara, N.A. Nucleic Acids Res. (1991) [Pubmed]
  2. Localisation of two candidate genes for mental retardation using a YAC physical map of the Xq21.1-21.2 subbands. Colleaux, L., May, M., Belougne, J., Lepaslier, D., Schwartz, C., Fontes, M. J. Med. Genet. (1996) [Pubmed]
  3. Cloning and expression analysis of two ZFY-related zinc finger genes from Alligator mississippiensis, a species with temperature-dependent sex determination. Valleley, E.M., Müller, U., Ferguson, M.W., Sharpe, P.T. Gene (1992) [Pubmed]
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