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Chemical Compound Review:

CHEBI:11369 [(2R,3S,5R,6S)-4-hydroxy- 2,3,5,6...

Synonyms: CHEBI:16322, I9261_SIGMA, HMDB03529, AC1L97EQ, C01284, ...

Llinás, R. et al., Hawkins, P.T. et al., Mason, D. et al., McConnell, F.M. et al., Fukuda, M. et al., et al.

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Disease relevance of C01284

In addition to its effects on phosphoinositides, SigD has been shown to convert inositol 1,3,4,5,6-pentakisphosphate (IP(5)) into inositol 1,4,5,6-tetrakisphosphate (IP(4)), and the latter has been postulated to mediate the diarrhea caused by Salmonella [1].

High impact information on C01284

We previously isolated a cDNA encoding the mammalian inositol 1,3,4,5,6-pentakisphosphate (InsP5) 2-kinase (2-kinase), the enzyme that converts InsP5 to InsP6 [2].
Synaptotagmin (Syt) is an inositol high-polyphosphate series [IHPS inositol 1,3,4,5-tetrakisphosphate (IP4), inositol 1,3,4,5,6-pentakisphosphate, and inositol 1,2,3,4,5,6-hexakisphosphate] binding synaptic vesicle protein [3].
Presynaptic injection of inositol 1,3,4,5-tetraphosphate, inositol 1,3,4,5,6-pentakisphosphate, or inositol 1,2,3,4,5,6-hexakisphosphate--which we denote here the inositol high-polyphosphate series (IHPS)--is shown to block synaptic transmission when injected into the preterminal of the squid giant synapse [4].
Multiple inositol polyphosphate phosphatase (Minpp1) metabolizes inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphate (InsP(6)) with high affinity in vitro [5].
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal [6].

Biological context of C01284

Production of IP(6) predominately occurs through phosphorylation of inositol 1,3,4,5,6-pentakisphosphate (IP(5)) by a 2-kinase [7].
Mass changes of inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate during cell cycle progression in rat thymocytes [8].
The IC50 for competition by unlabelled InsP6 is approximately 100nM, whereas inositol 1,3,4,5,6 pentakisphosphate (Ins(13456)P5), inositol 1,3,4,5 tetrakisphosphate (Ins(1345)P4), and inositol 1,4,5 trisphosphate (Ins(145)P3) bind with an affinity at least one order of magnitude lower [9].

Anatomical context of C01284

Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,4,5,6-pentakisphosphate and L-inositol 1,2,4,5,6-pentakisphosphate [10].

Associations of C01284 with other chemical compounds

On the other hand, the PH domains from RAC-protein kinase and diacylglycerol kinase specifically bound inositol 1,3,4,5,6-pentakisphosphate and inositol 1,4,5,6-tetrakisphosphate most strongly [11].

Gene context of C01284

Given that the kinase required for inositol 1,3,4,5,6-pentakisphosphate production (Ipk2) is localized in the nucleus, these results indicated that soluble inositides were diffusing between the nucleus and the cytoplasm [12].
In fungal cells, a 2-kinase designated Ipk1 is responsible for synthesis of InsP(6) by phosphorylation of inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) [13].

References

Alteration of Epithelial Structure and Function Associated with PtdIns(4,5)P2 Degradation by a Bacterial Phosphatase. Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L., Grinstein, S. J. Gen. Physiol. (2007) [Pubmed]
Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression. Verbsky, J., Lavine, K., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal. Fukuda, M., Moreira, J.E., Lewis, F.M., Sugimori, M., Niinobe, M., Mikoshiba, K., Llinás, R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
The inositol high-polyphosphate series blocks synaptic transmission by preventing vesicular fusion: a squid giant synapse study. Llinás, R., Sugimori, M., Lang, E.J., Morita, M., Fukuda, M., Niinobe, M., Mikoshiba, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Chi, H., Yang, X., Kingsley, P.D., O'Keefe, R.J., Puzas, J.E., Rosier, R.N., Shears, S.B., Reynolds, P.R. Mol. Cell. Biol. (2000) [Pubmed]
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal. Orchiston, E.A., Bennett, D., Leslie, N.R., Clarke, R.G., Winward, L., Downes, C.P., Safrany, S.T. J. Biol. Chem. (2004) [Pubmed]
Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases. Ives, E.B., Nichols, J., Wente, S.R., York, J.D. J. Biol. Chem. (2000) [Pubmed]
Mass changes of inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate during cell cycle progression in rat thymocytes. Guse, A.H., Greiner, E., Emmrich, F., Brand, K. J. Biol. Chem. (1993) [Pubmed]
Identification of a novel inositol phosphate recognition site: specific [3H]inositol hexakisphosphate binding to brain regions and cerebellar membranes. Hawkins, P.T., Reynolds, D.J., Poyner, D.R., Hanley, M.R. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,4,5,6-pentakisphosphate and L-inositol 1,2,4,5,6-pentakisphosphate. McConnell, F.M., Stephens, L.R., Shears, S.B. Biochem. J. (1991) [Pubmed]
Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein. Takeuchi, H., Kanematsu, T., Misumi, Y., Sakane, F., Konishi, H., Kikkawa, U., Watanabe, Y., Katan, M., Hirata, M. Biochim. Biophys. Acta (1997) [Pubmed]
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway. Miller, A.L., Suntharalingam, M., Johnson, S.L., Audhya, A., Emr, S.D., Wente, S.R. J. Biol. Chem. (2004) [Pubmed]
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Verbsky, J.W., Wilson, M.P., Kisseleva, M.V., Majerus, P.W., Wente, S.R. J. Biol. Chem. (2002) [Pubmed]

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