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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Echinococcus

  • Hydatid cyst fluid isolated from sheep infected with Echinococcus granulosus contains a glycoprotein (P1gp) with a terminal alpha-D-Galp-(1----4)-D-Galp disaccharide [1].
  • The mitochondrial rRNA of the tapeworm species Echinococcus multilocularis carries an adenine at sequence position 2058 (numbering according to that for Escherichia coli) of the large-subunit rRNA (lsrRNA), while the nucleus-encoded rRNA, as determined in this study, is characterized by 2058G [2].
  • Jirds (Meriones unguiculatus) inoculated intraperitoneally with cystic material of Echinococcus multilocularis were given daily oral treatments of praziquantel at 300 mg/kg of body weight (bw) or dimethyl sulfoxide vehicle for five-day treatment regimens starting at 29 days postinoculation (PI) up to 69 days PI [3].
  • Immunisation with Salmonella typhimurium-delivered glyceraldehyde-3-phosphate dehydrogenase protects mice against challenge infection with Echinococcus multilocularis eggs [4].
  • To investigate the role of the IgE-immunoreactive recombinant Echinococcus granulosus elongation factor-1 beta/delta (EgEF-1 beta/delta) in the allergic disorders during CE we determined humoral and cell-mediated responses to this antigen in patients with CE grouped according to the clinical presence or absence of allergic reactions [5].

High impact information on Echinococcus

  • Thirty-two patients with cysts caused by Echinococcus granulosus were treated with albendazole in a dosage of 10 mg/kg/day [6].
  • The diagnosis of an Echinococcus multilocularis infection is routinely performed by radiological techniques and by the detection of specific antibodies in the sera of infected patients [7].
  • Diagnosis of Echinococcus multilocularis infection by reverse-transcription polymerase chain reaction [7].
  • In this study, we cloned from the helminth parasite Echinococcus granulosus two trans-spliced mRNA variants that encode thioredoxin glutathione reductases (TGR) [8].
  • A major Echinococcus multilocularis antigen is a mucin-type glycoprotein [9].

Chemical compound and disease context of Echinococcus


Biological context of Echinococcus


Anatomical context of Echinococcus


Associations of Echinococcus with chemical compounds


Gene context of Echinococcus

  • We compared IL-10, IL-5, interferon-gamma (IFN-gamma) and tumour necrosis factor (TNF) secretion by peripheral blood mononuclear cells (PBMC) isolated from eight HLA-DR3+, DQ2+, B8+ AE patients and from 10 HLA-DR3-, DQ2-, B8- patients after non-specific mitogenic and specific Echinococcus multilocularis antigenic in vitro stimulation [28].
  • Comparison of the closely related sequences of human, murine and porcine moesin, ezrin and radixin with a protein from Echinococcus multilocularis, an evolutionarily quite distant human parasite, reveals several highly invariant domains in the aminoterminal and carboxyterminal regions [29].
  • Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage [30].
  • Pro-inflammatory (IL-1beta, IL-18) cytokines and IL-8 chemokine release by PBMC in response to Echinococcus multilocularis metacestode vesicles [31].
  • Expression of CD30L mRNA and the variant form of CD30 mRNA was frequently detected at individual time points during 72 h of culture of PBMC stimulated with crude Echinococcus antigen [32].

Analytical, diagnostic and therapeutic context of Echinococcus


  1. Enzyme-linked immunosorbent assay for Shiga toxin and Shiga-like toxin II using P1 glycoprotein from hydatid cysts. Acheson, D.W., Keusch, G.T., Lightowlers, M., Donohue-Rolfe, A. J. Infect. Dis. (1990) [Pubmed]
  2. Mitochondrial ribosome as the target for the macrolide antibiotic clarithromycin in the helminth Echinococcus multilocularis. Mathis, A., Wild, P., Boettger, E.C., Kapel, C.M., Deplazes, P. Antimicrob. Agents Chemother. (2005) [Pubmed]
  3. Enhanced larval cyst growth of Echinococcus multilocularis in praziquantel-treated jirds (Meriones unguiculatus). Marchiondo, A.A., Ming, R., Andersen, F.L., Slusser, J.H., Conder, G.A. Am. J. Trop. Med. Hyg. (1994) [Pubmed]
  4. Immunisation with Salmonella typhimurium-delivered glyceraldehyde-3-phosphate dehydrogenase protects mice against challenge infection with Echinococcus multilocularis eggs. Müller-Schollenberger, V., Beyer, W., Schnitzler, P., Merckelbach, A., Roth, S., Kalinna, B.H., Lucius, R. Int. J. Parasitol. (2001) [Pubmed]
  5. Elongation factor 1 beta/delta of Echinococcus granulosus and allergic manifestations in human cystic echinococcosis. Ortona, E., Margutti, P., Vaccari, S., Riganò, R., Profumo, E., Buttari, B., Chersi, A., Teggi, A., Siracusano, A. Clin. Exp. Immunol. (2001) [Pubmed]
  6. Albendazole--objective evidence of response in human hydatid disease. Morris, D.L., Dykes, P.W., Marriner, S., Bogan, J., Burrows, F., Skeene-Smith, H., Clarkson, M.J. JAMA (1985) [Pubmed]
  7. Diagnosis of Echinococcus multilocularis infection by reverse-transcription polymerase chain reaction. Kern, P., Frosch, P., Helbig, M., Wechsler, J.G., Usadel, S., Beckh, K., Kunz, R., Lucius, R., Frosch, M. Gastroenterology (1995) [Pubmed]
  8. Alternative mRNAs arising from trans-splicing code for mitochondrial and cytosolic variants of Echinococcus granulosus thioredoxin Glutathione reductase. Agorio, A., Chalar, C., Cardozo, S., Salinas, G. J. Biol. Chem. (2003) [Pubmed]
  9. A major Echinococcus multilocularis antigen is a mucin-type glycoprotein. Hülsmeier, A.J., Gehrig, P.M., Geyer, R., Sack, R., Gottstein, B., Deplazes, P., Köhler, P. J. Biol. Chem. (2002) [Pubmed]
  10. Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates. Franchi, C., Di Vico, B., Teggi, A. Clin. Infect. Dis. (1999) [Pubmed]
  11. Unique precipitation and exocytosis of a calcium salt of myo-inositol hexakisphosphate in larval Echinococcus granulosus. Irigoín, F., Casaravilla, C., Iborra, F., Sim, R.B., Ferreira, F., Díaz, A. J. Cell. Biochem. (2004) [Pubmed]
  12. Serum antibody response following parenteral immunization with hydatid cyst fluid in sheep infected with Echinococcus granulosus. Lightowlers, M.W., Rickard, M.D., Honey, R.D. Am. J. Trop. Med. Hyg. (1986) [Pubmed]
  13. Anthelmintic effects of cyclosporin A on protoscoleces and secondary hydatid cysts of Echinococcus granulosus in the mouse. Hurd, H., Mackenzie, K.S., Chappell, L.H. Int. J. Parasitol. (1993) [Pubmed]
  14. Increases in the effects of albendazole on Echinococcus multilocularis metacestodes by the dipeptide methyl ester (Phe-Phe-OMe). Sarciron, M.E., Walchshofer, N., Walbaum, S., Arsac, C., Descotes, J., Petavy, A.F., Paris, J. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  15. Antibody responses to in vitro translation products following albendazole therapy for Echinococcus granulosus. Blanton, R.E., Okelo, G.B., Kijobe, J., King, C.H. Antimicrob. Agents Chemother. (1991) [Pubmed]
  16. A new potent antigen from Echinococcus granulosus associated with muscles and tegument. Fu, Y., Martinez, C., Chalar, C., Craig, P.S., Ehrlich, R., Petavy, A.F., Bosquet, G. Mol. Biochem. Parasitol. (1999) [Pubmed]
  17. Water and electrolyte balance in protoscoleces of Echinococcus granulosus incubated in vitro: general procedures for the determination of water, sodium, potassium and chloride in protoscoleces. Reisin, I.L., Rotunno, C.A. Int. J. Parasitol. (1981) [Pubmed]
  18. Molecular cloning and characterization of actin genes from Echinococcus granulosus. da Silva, C.M., Henrique, n.u.l.l., Ferreira, B., Picón, M., Gorfinkiel, N., Ehrlich, R., Zaha, A. Mol. Biochem. Parasitol. (1993) [Pubmed]
  19. Hydatid disease associated with hepatic outflow tract obstruction. Koshy, A., Bhusnurmath, S.R., Mitra, S.K., Mahajan, K.K., Datta, D.V., Aikat, B.K., Bhagwat, A.G. Am. J. Gastroenterol. (1980) [Pubmed]
  20. IL-5 expressed by CD4+ lymphocytes from Echinococcus multilocularis-infected patients. Jenne, L., Kilwinski, J., Scheffold, W., Kern, P. Clin. Exp. Immunol. (1997) [Pubmed]
  21. In vivo treatment with recombinant IL-12 protects C57BL/6J mice against secondary alveolar echinococcosis. Emery, I., Leclerc, C., Sengphommachanh, K., Vuitton, D.A., Liance, M. Parasite Immunol. (1998) [Pubmed]
  22. Treatment of cystic echinococcosis (Echinococcus granulosus) with mebendazole: assessment of bound and free drug levels in cyst fluid and of parasite vitality in operative specimens. Luder, P.J., Witassek, F., Weigand, K., Eckert, J., Bircher, J. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  23. Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model. Taylor, D.H., Morris, D.L., Reffin, D., Richards, K.S. Gut (1989) [Pubmed]
  24. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Ingold, K., Bigler, P., Thormann, W., Cavaliero, T., Gottstein, B., Hemphill, A. Antimicrob. Agents Chemother. (1999) [Pubmed]
  25. Effects of multiple doses of isoprinosine on Echinococcus multilocularis metacestodes. Sarciron, M.E., Delabre, I., Walbaum, S., Raynaud, G., Petavy, A.F. Antimicrob. Agents Chemother. (1992) [Pubmed]
  26. myo-Inositol hexakisphosphate is a major component of an extracellular structure in the parasitic cestode Echinococcus granulosus. Irigoín, F., Ferreira, F., Fernández, C., Sim, R.B., Díaz, A. Biochem. J. (2002) [Pubmed]
  27. In vitro parasiticidal effect of Nitazoxanide against Echinococcus multilocularis metacestodes. Stettler, M., Fink, R., Walker, M., Gottstein, B., Geary, T.G., Rossignol, J.F., Hemphill, A. Antimicrob. Agents Chemother. (2003) [Pubmed]
  28. Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile in humans. II. Influence of the HLA B8, DR3, DQ2 haplotype. Godot, V., Harraga, S., Beurton, I., Tiberghien, P., Sarciron, E., Gottstein, B., Vuitton, D.A. Clin. Exp. Immunol. (2000) [Pubmed]
  29. Cloning and sequencing of porcine moesin and radixin cDNA and identification of highly conserved domains. Lankes, W.T., Schwartz-Albiez, R., Furthmayr, H. Biochim. Biophys. Acta (1993) [Pubmed]
  30. Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage. Li, J., Zhang, W.B., Loukas, A., Lin, R.Y., Ito, A., Zhang, L.H., Jones, M., McManus, D.P. Gene (2004) [Pubmed]
  31. Pro-inflammatory (IL-1beta, IL-18) cytokines and IL-8 chemokine release by PBMC in response to Echinococcus multilocularis metacestode vesicles. Eger, A., Kirch, A., Manfras, B., Kern, P., Schulz-Key, H., Soboslay, P.T. Parasite Immunol. (2003) [Pubmed]
  32. Expression of CD30 mRNA, CD30L mRNA and a variant form of CD30 mRNA in restimulated peripheral blood mononuclear cells (PBMC) of patients with helminthic infections resembling a Th2 disease. Kilwinski, J., Berger, T., Mpalaskas, J., Reuter, S., Flick, W., Kern, P. Clin. Exp. Immunol. (1999) [Pubmed]
  33. Coproantigen detection in dogs experimentally and naturally infected with Echinococcus granulosus by a monoclonal antibody-based enzyme-linked immunosorbent assay. Malgor, R., Nonaka, N., Basmadjian, I., Sakai, H., Carámbula, B., Oku, Y., Carmona, C., Kamiya, M. Int. J. Parasitol. (1997) [Pubmed]
  34. Molecular cloning and characterization of an Echinococcus granulosus cDNA encoding malate dehydrogenase. Rodrigues, J.J., Ferreira, H.B., Zaha, A. Mol. Biochem. Parasitol. (1993) [Pubmed]
  35. Nitric oxide-mediated immunosuppression following murine Echinococcus multilocularis infection. Dai, W.J., Gottstein, B. Immunology (1999) [Pubmed]
  36. Copro-diagnosis of Echinococcus granulosus infection in dogs by amplification of a newly identified repeated DNA sequence. Abbasi, I., Branzburg, A., Campos-Ponce, M., Abdel Hafez, S.K., Raoul, F., Craig, P.S., Hamburger, J. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
  37. Molecular cloning, expression and characterization of a recombinant glutathione S-transferase from Echinococcus multilocularis. Liebau, E., Müller, V., Lucius, R., Walter, R.D., Henkle-Dührsen, K. Mol. Biochem. Parasitol. (1996) [Pubmed]
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